[1]石大伟,赵永成.电离辐射诱导的DNA甲基化模式改变及其在辐射致癌机制研究中的意义[J].国际放射医学核医学杂志,2006,30(4):240-243.
 SHI Da-wei,ZHAO Yong-cheng.Radiation-induced DNA methylation profile changes and its impact on mechanisms of radiation carcinogenesis[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):240-243.
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电离辐射诱导的DNA甲基化模式改变及其在辐射致癌机制研究中的意义(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第4期
页码:
240-243
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
Radiation-induced DNA methylation profile changes and its impact on mechanisms of radiation carcinogenesis
作者:
石大伟 赵永成
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所生物学研究室
Author(s):
SHI Da-wei ZHAO Yong-cheng
Department of Biology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
关键词:
肿瘤辐射性DNA甲基化表观遗传
Keywords:
Neoplasms radiation-inducedDNA methylationEpigenetics
分类号:
Q691.5
摘要:
越来越多的研究已经表明,表观遗传机制在癌症发生发展中扮演了非常重要的角色,但是对于辐射致癌的表观遗传机制的研究仅刚刚起步。本文介绍了表观遗传和一种重要的表观遗传标志——DNA甲基化的相关概念,并综述了近年来人们对电离辐射诱导的DNA甲基化模式改变的研究以及DNA甲基化模式改变在辐射致癌机制研究中的意义。
Abstract:
More and more evidence has been accumulated to indicate that epigenetic mechanisms play a important role in carcinogenesis. However, the studies on epigenetic mechanisms of radiation carcinogenesis are at their dawn. Here the related concepts of DNA methylation and epigenetics were introduced, and summarized the studies on radiation-induced DNA methylation changes in recent years and its meaning to radiation carcinogenesis.

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备注/Memo

备注/Memo:
收稿日期:2006-02-08。
通讯作者:石大伟,,E-mail:davidstone340@yahoo.com
更新日期/Last Update: 1900-01-01