[1]金问森,金一尊.整合素介导的细胞信号转导与肿瘤辐射敏感性[J].国际放射医学核医学杂志,2006,30(4):237-239.
 JIN Wen-sen,JIN Yi-zun.Signal transduction pathway mediated by integrin and tumor radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):237-239.
点击复制

整合素介导的细胞信号转导与肿瘤辐射敏感性(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第4期
页码:
237-239
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Signal transduction pathway mediated by integrin and tumor radiosensitivity
作者:
金问森 金一尊
200032 上海, 复旦大学放射医学研究所第八研究室
Author(s):
JIN Wen-sen JIN Yi-zun
The Eighth Laboratory in Institute of Radiation Medicine, Fudan University, Shanghai 200032, China
关键词:
整合素肿瘤信号转导辐射耐受性
Keywords:
IntegrinNeoplasmsSignal transductionRadiation tolerance
分类号:
Q257;R730.55
摘要:
整合素作为重要的细胞黏附分子,可介导细胞的信号转导,在细胞的黏附、迁移、增殖、分化等生长活动中发挥重要作用。同时,在电离辐射条件下,整合素介导的细胞信号转导可在肿瘤细胞内激活多种蛋白激酶,启动不同的信号通路,调控基因表达,维持肿瘤细胞的存活,降低肿瘤的辐射敏感性。因此,深入了解整合素及其所介导的细胞信号转导途径,有利于新型辐射增敏剂的研究,对肿瘤治疗具有积极意义。
Abstract:
Integrins are a group of significant cell adhesion molecules and participate in the regulation of critical functions through cellular signal trusduction, including cell adhesion, migration, proliferation, differentiation, and so on. The integrin-mediated signaling, meanwhile, may activate a variety of protein kinases after ionizing radiation, and then form different intracellular signal pathways in order to regulate the expression of gene. As consequence, these signal pathways induce the reduction of the radiosensitivity of tumor cells for survival event. To understand integrin-mediated signal trasduciton, therefore, has the vital influence on the study of radiosensitizer and radiotherapy.

参考文献/References:

1 Cordes N,Beinke C,Plasswilm L,et al.Irradiation and various cytoto xic drugs enhance tyrosine phosphorylation and β1-integrin clustering in human A549 lung cancer cells in a substratum-dependent manner in vitro.Strahlenther Onkol,2004,180(3):157-164.
2 Hynes RO.Integrins:bidirectional,allosteric signaling machines.Cell,2002,110(6):673-687.
3 Ridley AJ,Schwartz MA,Burridge K,et al.Cell migration:integrating signals from front to back.Science,2003,302(5651):1704-1709.
4 Martin KH,Slack JK,Boeruer SA,et al.Integrin connections map:to infinity and beyond.Science,2002,296(5573):1652-1653.
5 Cordes N,Meineke V.Integrin signalling and the cellular response to ionizing radiation.J Mol Histol,2004,35(3):327-337.
6 Cordes N,Blaese MA,Meineke V,et al.Ionizing radiation induces up-regulattional β1-integrin in human lung tumor cell lines in vitro.Int J Radit Biol,2002,78(5):347-357.
7 Beinke C,Beuingen DV,Cordes N.Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesionassociated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro.Int J Radit Biol,2003,79(9):721-731.
8 Almeida EAC,Ilic D,Han Q,et al.Matrix survival signaling; from fibronectin via focal adhesion kinase to c-Jun NH-terminal kinase.J Cell Biol,2000,149(3):741-754.
9 Wei L,Yang A,Zhang X,et al.Anchorage-independent phosphorylation of p130(Cas) protects lung adenocarcinoma cells from anoiks.J Cell Biochem,2002,87(4):439-449.
10 Grimes CA,Jope RS.The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.Prog Neurobiol,2001,65(4):391-426.
11 Hoeflich KP,Luo J,Rubie EA,et al.Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation.Nature,2000,406(6791):86-90.
12 Zhang Y,Chen K,Tu Y,et al.Assembly of the PINCH-ILK-CHILKBP complex precedes and is essential for localization each component to cell-matrix adhesion sites.J Cell Sci,2002,115(Pt24):4777-4786.
13 Cordes N,Overexpression of hyperactive integrin-linked leads to increased cellular radiosensitivity.Cancer Res,2004,64(16):5683-5692.
14 Cordes N,Meineke V.Cell adhesion-mediated radioresistance(Cam-RR):extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro.Strahlenther Onkol,2003,179(5):337-344.
15 Cordes N,Hansmeier B,Meineke V.Irradiation differentially affects substratum-dependent survival adhesion,and invasion of glioblastoma cell lines.Br J Cancer,2003,89(11):2122-2132.
16 Abdollahi A,Griggs DW,Zieher H,et al.Inhibition of αvβ3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy.Clin Cancer Res,2005,11(17):6270-6279.
17 Burke PA,Denardo SJ,Miers LA,et al.Combined modality radioimmunotherapy.Promise and peril.Cancer,2002,94(4 Suppl):1320-1331.
18 Huber PE,Bischof M,Jenne J,et al.Trimodal cancer treatment:beneficial effects of combined antiangiogenesis,radiation,and chemotherapy.Cancer Res,2005,65(9):3643-3655.
19 Edwards E,Geng L,Tan J,et al.Phosphatidylinositol3-kinase/Akt signaling in the reponse of vascular endothelium to ionizing radiation.Cancer Res,2002,62(16):4671-4677.

相似文献/References:

[1]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
 He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[2]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
 Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[3]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[4]陈晓艳,张江虹,邵春林.STAT3与辐射敏感相关性的研究进展[J].国际放射医学核医学杂志,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
 Chen Xiaoyan,Jianghong,Shao Chunlin.Research progresses of correlation between STAT3 and radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
[5]赵舒怡,储小飞,樊赛军.血清肿瘤标志物与肿瘤放疗疗效评估的研究进展[J].国际放射医学核医学杂志,2015,39(5):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
 zhao shuyi,chu xiaofei,fan saijun..progression of study on serum tumor markers in evaluation of tumor radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
[6]赵徵鑫,翟贺争,张文艺,等.质子重离子治疗肿瘤的进展[J].国际放射医学核医学杂志,2016,40(5):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
 Zhao Zhixin,Zhai Hezheng,Zhang Wenyi,et al.Development of proton heavy ion in tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
[7]任佳忠,李永梅,刘岩,等.99Tcm-MDP骨显像胸部异常放射性摄取的原因分析[J].国际放射医学核医学杂志,2016,40(6):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
 Jiazhong,Li Yongmei,Liu Yan,et al.Reasons for the abnormal 99Tcm-MDP uptake in the thoracic tissue on bone scintigraphy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
[8]马彦云,张辉.磁共振体素内不相干运动扩散加权成像的原理及应用进展[J].国际放射医学核医学杂志,2016,40(6):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
 Ma Yanyun,Zhang Hui.The basic principle and application progress of intravoxel incoherent motion imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
[9]杨卫东,汪静.肿瘤核素靶向治疗新进展[J].国际放射医学核医学杂志,2015,39(1):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
 Yang Weidong,Wang Jing.Advance progress of radionuclide target tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
[10]徐金苹,袁德晓,张江虹,等.辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用[J].国际放射医学核医学杂志,2015,39(2):144.[doi:10.3760/cma.j.issn.1673-4114.2015.02.009]
 Xu Jinping,Yuan Dexiao,Zhang Jianghong,et al.The role of radiation-induced exosomes in tumor invasion and metastasis[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):144.[doi:10.3760/cma.j.issn.1673-4114.2015.02.009]

备注/Memo

备注/Memo:
收稿日期:2006-03-20。
基金项目:国家自然科学基金项目(30500143)
通讯作者:金一尊,E-mail:yzjin@shmu.edu.cn
更新日期/Last Update: 1900-01-01