[1]苏新辉,吴华.99mTc-HL91乏氧显像探测肿瘤乏氧状态的研究进展[J].国际放射医学核医学杂志,2006,30(4):220-222.
 SU Xin-hui,WU Hua.Advances in identifying the hypoxic status of malignant tumors with 99mTc-HL91 scintigraphy[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):220-222.
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99mTc-HL91乏氧显像探测肿瘤乏氧状态的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第4期
页码:
220-222
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Advances in identifying the hypoxic status of malignant tumors with 99mTc-HL91 scintigraphy
作者:
苏新辉 吴华
361003 厦门, 福建医科大学附属厦门第一医院核医学科
Author(s):
SU Xin-hui WU Hua
Department of Nuclear Medicine, Xiamen First Hospital, Fujian Medical University, Xiamen 361003, China
关键词:
细胞低氧放射性核素显像99mTc-HL91
Keywords:
Cell hypoxiaRadionuclide imaging99mTc-HL91
分类号:
R817.4
摘要:
乏氧显像剂99mTc-HL91能选择眭地浓集于肿瘤的乏氧组织或细胞中,通过核医学显像探测肿瘤组织的乏氧,能直接提供肿瘤组织乏氧及其乏氧程度和分布的证据,不仅能用于恶性肿瘤的早期诊断,还能动态监测肿瘤组织乏氧状态,为临床诊断和治疗决策提供重要信息。
Abstract:
99mTc-HL91 is a hypoxic agent and can be uptaken by hypoxic issues or cells of malignant tumors. It may be able to provide the information directly in detection of hypoxic status of tumors through imaging. It may be used not only in the early diagnosis of malignant tumors, but also in dynamic detection of hypoxic status of tumors. Thus significant information may be obtained for clinical diagnosis and treatment.

参考文献/References:

1 Ballinger JR.Imaging hypoxia in tumors.Semin Nucl Med,2001,31(4):321-329.
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3 Cook GJ,Houston S,Berrington SF,et al.Technetium-99m-labeled HL91 to identify tumor hypoxia:correlation with 18F-FDG.J Nucl Med,1998,39(1):99-103.
4 Van De Wiele C,Versijpt J,Dierckx RA,et al.99mTc labeled HL91 versus computed tomography and biopsy for the visualization of tumor recurrence of squamous head and neck carcinoma.Nucl Med Commun,2001,22(3):269-275.
5 冯彦林,谭家驹,杨劼,等.99mTc-HL91肺部恶性肿瘤乏氧显像的临床研究.中国现代医学杂志,2002,12(21):40-41.
6 邓波,陈小凤,肖欢.99mTc-HL91乏氧显像与99mTc-MIBI亲肿瘤显像诊断肺肿瘤的对比分析.中国误诊学杂志,2003,3(12):1795-1797.
7 Kinuya S,Yokoyama K,Konishi S,et al.Increased uptake of 99mTc-HL91 in tumor cells exposed to X-ray radiation.Ann Nucl Med,2000,14(2):139-141.
8 李玲,邢力刚,于金明,等.非小细胞肺癌放疗中99mTc-HL91 SPECT乏氧显像研究.中华核医学杂志,2005,25(4):222-223.
9 Mizumoto K,Qian LW,Zhang L,et al.A nitroimidazole derivative,PR-350,enhances the killing of pancreatic cancer cells exposed to high-dose irradiation under hypoxia.J Radiat Res (Tokyo),2002,43(1):43-51.
10 Suzuki T,Nakamura K,Kawase T,et al.Monitoring of response to radiation therapy for human tumor xenografts using 99mTc-HL91(4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione doixime).Ann Nucl Med,2003,17(2):131-138.

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备注/Memo

备注/Memo:
收稿日期:2005-11-16。
通讯作者:苏新辉,E-mail:suxinhui2008@hotmail.com
更新日期/Last Update: 1900-01-01