[1]闫风琴,鞠桂芝.辐射及细胞因子对p21基因表达的调控作用[J].国际放射医学核医学杂志,2004,28(6):278-280.
 YAN Feng-qin,JU Gui-zhi.The regulation of radiation and cytokines to p21 gene expression[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(6):278-280.
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辐射及细胞因子对p21基因表达的调控作用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
28
期数:
2004年第6期
页码:
278-280
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
The regulation of radiation and cytokines to p21 gene expression
作者:
闫风琴 鞠桂芝
130021 长春, 吉林大学公共卫生学院放射生物学教研室
Author(s):
YAN Feng-qin JU Gui-zhi
Department of Radiation Biology, Pubilc Health School, Jilin University, Changchun 130021, China
关键词:
辐射细胞因子p21基因基因表达调控
Keywords:
radiationcytokinep21 genegene expression regulation
分类号:
Q345+.2
摘要:
p21基因是细胞周期的负向调控因子,在一定的因素诱导下,p21基因可有效地引起细胞周期G1期和G2期阻滞,从而在维持基因组稳定性中起重要作用。辐射及TGFβ1、TNFα、PTEN、IGF等因子均可诱导p21基因表达增高,而E1A、c-jun、Tbx2、PLD1和PLD2等因子则抑制p21基因表达。
Abstract:
p21 gene is a negative regulator of cell cycle, which affect cell cycle progression arrest at G1 and G2 by some factors induced. p21 gene plays an important role to maintain genomic stability. Radiation and TGFβ1, TNFα, PTEN, IGF can increase p21 gene expression, however E1A, c-jun, Tbx2, PLD1 and PLD2 can inhibit p21 gene expression.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2004-07-11。
更新日期/Last Update: 1900-01-01