[1]李雨,潘真,蔡建明.AT的信号传导[J].国际放射医学核医学杂志,2001,25(2):82-86.
　LI Yu,PAN Zhen,CAI Jian-ming.Signal transduction of ataxia-telangiectasia[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(2):82-86.
点击复制

AT的信号传导(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第2期
页码:
82-86
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Signal transduction of ataxia-telangiectasia
作者:
李雨;  潘真;  蔡建明
200433 上海, 第二军医大学放射医学教研室
Author(s):
LI Yu;  PAN Zhen;  CAI Jian-ming
Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China
关键词:
共济失调-毛细血管扩张症; 电离辐射; 信号传导
Keywords:
ataxia telangiectasia; ionizing radiation; signal transduction
分类号:
R811.5
摘要:
基因缺陷所致共济失调-毛细血管扩张症(AT)表现为免疫缺陷、进行性共济失调、性腺发育异常、辐射敏感和易患癌症等。本文综述了AT的信号传导,包括AT基因突变和临床症状、电离辐射诱导的信号传导通路中的一些转录因子、细胞周期检控点异常、持续的氧应激和细胞凋亡等。
Abstract:
The genetic disorder ataxia-telangiectasia (AT) is characterized by immunodeficiency, progressive cerebellar ataxia, gonadal abnormalities, radiosensitivity, and cancer predisposition. In this paper, the signal transduction of AT are reviewed, including ATM (AT mutated) gene and clinicalsymptoms, some transoription factors in the signaling pathway induced by ionizing radiation, cell cycle checkpoint defects, durative oxidative stress and cell apoptosis.

参考文献/References:

[1] Lavin M F.ATM:the product of the gene mutated in ataxia-telangiectasia[J].Int J Biochem Cell Biol,1999,31(7):735-740.
[2] Gang C,Eva Y,Lee HP.The product of the ATM Gene is a 370 kda Nuclear Phosphoprotein[J].J Biol Chem,1996,271:33693-33697.
[3] Crawford TO.Ataxia telangiectasia[J].Semin Pediatr Neurol,1998,5(4):287-294.
[4] Keegan KS,Holtzman DA,Plug AW,et al.The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes[J].Genes Dev,1996,10(19):2423-2437.
[5] International Commission on Radiological Protection.Genetic susceptibility to cancer[J].Ann ICRP,1998;28(1-2):1-157.
[6] Karin M and Hunter T.Transcriptional control by protein phosphorylation:signal transmission from the cell surface to the nucleus[J].Curr Biol,1995,5(7):747-757.
[7] Canman CE,Wolff AC,Chen CY,et al.The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia[J].Cancer Res,1994,54 (19):5054-5058.
[8] Khanna KK,Beamish H,Yan J,et al.Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia[J].Oncogene,1995,11(4):609-618.
[9] Khanna KK,Keating KE,Kozlov S,et al.ATM associates with and phosphorylates p53:mapping the region of interaction[J].Nat Genet,1998,20(4):398-400.
[10] BarlowC,Brown KD,Deng CX,et al.Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways[J].Nat Genet,1997,17(4):453-456.
[11] Kohli M,Jorgensen TJ.The influence of SV40 immortalization of human fibroblasts on p53-dependent radiation responses[J].Biochem Biophys Res Commun,1999,257(1):168-176.
[12] Beamish H,Williams R,Chen P,et al.Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation[J].J Biol Chem,1996,271 (34):20486-20493.
[13] Painter RB,Young BR.Radiosensitivity in ataxia-telangiectasia:a new explanation[J].Proc Natl Acad Sci USA,1980,77(12):7315-7317.
[14] Zhang N,Chen P,Gatei M,et al.An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells[J].Oncogene,1998,17(7):811-818.
[15] de Murcia G,Menissier de Murcia J.Poly (ADP-ribose) polymerase:a molecular nick-sensor[J].Trends Biochem Sci,1994,19(4):172-176.
[16] Paules RS,Levedakou EN,Wilson-SJ,et al.Defective G2 checkpoint function in cells from individuals with familial cancer syndromes[J].Cancer Res,1995,55(8):1763-1773.
[17] Kyriakis JM,Avruch J.Sounding the alarm:protein kinase cascades activated by stress and inflammation[J].J Biol Chem,1996,271(40):24313-24316.
[18] Kharbanda S,Ren R,Pandey P,et al.Activation of the c-Ab1 tyrosine kinase in the stress response to DNA-damaging agents[J].Nature,1995,376(6543):785-788.
[19] Shafman T,Khanna KK,Kedar P,et al.Interaction between ATM protein and c-Ab1 in response to DNA damage[J].Nature,1997,387(6632):520-523.
[20] Baskaran R,Wood LD,Whitaker LL,et al.Ataxia telangiectasia mutant protein activates c-Ab1 tyrosine kinase in response to ionizing radiation[J].Nature,1997,387(6632):516-519.
[21] Pendergast AM.Nuclear tyrosine kinases:from Ab1 to WEE1[J].Curr Opin Cell Biol,1996,174-181.
[22] Sen CK,Packer L.Antioxidant and redox regulation of gene transcription[J].J FASEB,1996,10(7):709-720.
[23] Baldwin AS Jr.The NF-kappa B and I kappa B proteins:new discoveries and insights[J].Annu Rev Immunol,1996,14:649-683.
[24] KaltschmidtB,Baeuerle PA,Kaltschmidt C.Potential involvement of the transcription factor NF-kappa B in neurological disorders[J].Mol Aspects Med,1993,14(3):171-190.
[25] Harper JW,Elledge SJ.Cdk inhibitors in development and cancer[J].Curr Opin Genet Dev,1996,6(1):56-64.
[26] Xu Y,Ashley T,Brainerd EE,et al.Targeted disruption of ATM leads to growth retardation,chromosomal fragmentation during meiosis,immune defects,and thymic lymphoma[J].Genes Dev,1996,10(19):2411-2422.
[27] Jaffrey SR,Snyder SH.Nitric oxide:a neural messenger[J].Ann Rev Cell Dev Biol,1995,11:417-440.
[28] Stadtman ER.Protein oxidation and aging[J].Science,1992,257(5074):1220-1224.

相似文献/References:

[1]任越,张慧芳,胡波,等.电离辐射诱导小鼠骨电子顺磁共振信号检测的影响因素[J].国际放射医学核医学杂志,2015,39(5):371.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 004]
　ren yue,zhang huifang,hu bo,et al.influencing factors of detection on ionizing radiation-induced electron paramagnetic resonance signal in bones[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):371.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 004]
[2]王平,关华顺,吕玉民.外周血核基因表达评价辐射生物剂量方法研究进展[J].国际放射医学核医学杂志,2014,38(6):416.[doi:10.3760/cma.j.issn.1673-4114.2014.06.016]
　Wang Ping,Guan Hua-shun,Lyu Yu-min.Advances of nuclear gene expression signatures in peripheral blood for irradiation biodose estimation[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(2):416.[doi:10.3760/cma.j.issn.1673-4114.2014.06.016]
[3]徐畅,王彦,杜利清,等.shRNA干扰沉默Net1基因对电离辐射损伤反应的影响[J].国际放射医学核医学杂志,2013,37(3):135.[doi:10.3760/cma.j.issn.1673-4114.2013.03.002]
　XU Chang,WANG Yan,DU Li-qing,et al.The effects of short hairpin RNA-mediated silencing Net1 on ionizing radiation-induced damage responses[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):135.[doi:10.3760/cma.j.issn.1673-4114.2013.03.002]
[4]刘忠超,张文艺,焦玲.辐射引起的电子自旋共振信号在回顾剂量学中的应用[J].国际放射医学核医学杂志,2013,37(5):322.[doi:10.3760/cma.j.issn.1673-4114.2013.05.016]
　LIU Zhong-chao,ZHANG Wen-yi,JIAO Ling.The application of radiation-induced free radicals signals in retrospective dosimetry[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):322.[doi:10.3760/cma.j.issn.1673-4114.2013.05.016]
[5]陈凤,涂彧.电离辐射诱导旁效应的研究现状[J].国际放射医学核医学杂志,2009,33(6):364.[doi:10.3760/cma.j.issn.1673-4114.2009.06.015]
　CHEN Feng,TU Yu.Bystander effect induced by ionizing radiation and its application[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):364.[doi:10.3760/cma.j.issn.1673-4114.2009.06.015]
[6]肖瑶,韩玲.电离辐射诱导旁效应的研究现状[J].国际放射医学核医学杂志,2007,31(5):303.
　XIAO Yao,HAN Ling.Recent study of ionizing radiation-induced bystander effects[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):303.
[7]李智恒,李雨.C57小鼠受照后胸腺细胞基因表达谱的变化[J].国际放射医学核医学杂志,2007,31(4):240.
　LI Zhi-heng,LI Yu.Profiling of differentially expressed genes induced by ionizing radiation in thymus cells of C57 mice[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):240.
[8]由莉,赵永成.γ-H2AX分析及其在监测电离辐射所致DNA双链断裂中的应用前景[J].国际放射医学核医学杂志,2006,30(1):50.
　YOU Li,ZHAO Yong-cheng.γ-H2AX assay and its prospect of detecting DNA double-strand breaks caused by ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):50.
[9]刘强,姜恩海,李进,等.SCGE作为辐射生物剂量计的可行性研究[J].国际放射医学核医学杂志,2005,29(3):126.
　LIU Qiang,JIANG En-hai,LI Jin,et al.Study on the possibility of SCGE as radiation biological dosimeter[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(2):126.
[10]高荣莲,陈肖华.星形胶质细胞的电离辐射损伤及修复作用[J].国际放射医学核医学杂志,2004,28(1):37.
　GAO Rong-lian,CHEN Xiao-hua.Injury and repair of astrocyte after ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(2):37.

备注/Memo

备注/Memo:
收稿日期:2000/1/20。
作者简介:李雨(1956-),男,河南开封人,上海第二军医大学放射医学教研室副教授,博士,主要从事DNA辐射损伤和修复的研究。;潘真(1948-),男,江苏溧阳人,上海第二军医大学放射医学教研室教授,博士后,主要从事放射生物医学的研究。;蔡建明(1958-),男,上海南汇人,上海第二军医大学放射医学教研室教授,博士,主要从事放射生物医学的研究。
更新日期/Last Update: 1900-01-01