[1]张军权,张浩.促血小板生成素与辐射损伤[J].国际放射医学核医学杂志,2000,24(4):173-177.
 ZHANG Jun-quan,ZHANG Hao.Thrombopoietin and radiation injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(4):173-177.
点击复制

促血小板生成素与辐射损伤(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
24
期数:
2000年第4期
页码:
173-177
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Thrombopoietin and radiation injury
作者:
张军权 张浩
100850 北京, 北京放射医学研究所
Author(s):
ZHANG Jun-quan ZHANG Hao
Beijing Institute of Radiation Medicing, Beijing 1000850, China
关键词:
促血小板生成素辐射损伤造血干细胞
Keywords:
thrombopoietinradiation injuryhematopoietic stem cell
分类号:
R818.4
摘要:
TPO(促血小板生成素)是巨核系造血的主要刺激因子,近年的研究表明,TPO与造血干细胞之间存在密切联系。TPO可促进辐射损伤后的造血重建,有可能解决急性放射病中血小板恢复滞后的问题。TPO在造血干细胞移植、血小板采集与分离等领域也有广阔的应用前景。
Abstract:
Thrombopoietin (TPO) is the primary regulator of megakaryocytopoiesis.Recent studies show that there is close relationship between TPO and hematopoietic stem cell.TPO can stimulate hematopoietic recovery af-ter radiation injury. TPO may have widespread use in such areas as hematopoietic stem cell transplantation, platelets collection and separation.

参考文献/References:

[1] Eaton DL, de Sauvage FJ. Thrombopoietin:the primary regulator of megakaryocytopoiesis and thrombopoiesis[J]. Exp Hematol, 1997, 25(1):1-7.
[2] Kaushansky K. Thrombopoietin and the hematopoietic stem cell[J]. Blood, 1998, 92(1):1-3.
[3] Alexander WS. Thrombopoietin and the c-Mpl receptor:insights from gene targeting[J]. Int J Biochem, Cell Biol, 1999, (10):1027-1035.
[4] Mouthon M A, Vandamme M, Gourmelon P, et al. Preferential liver irradiation enhancies hematopoiesis through a thrombopoietin-independent mechanism[J]. Radiat Res, 1999, 152(4):390-397.
[5] Cohen-Solal K, Villeval JL, Titeux M, et al. Constitutive expression of mpl ligand transcripts during thrombocytopenia or thrombocytosis[J]. Blood, 1996, 88(7):2578-2584.
[6] Kaushansky K, Lin N, Chossmann A, et al. Thrombopoietin expands erythroid, granulocyte macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice[J]. Exp Hematol, 1996, 24(2):265-269.
[7] Hokom M M, Lacey D, Kinstler OB, et al. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice[J]. Blood, 1995, 86(12):4486-4492.
[8] Farese AM, Hunt P, Grab LB, et al. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation induced marrow aplasia[J]. J Clin Invest, 1996, 97(9):2145-2151.
[9] Fibbe WE, Heemskerk DP, Laterveer L, et al. Accelerated reconstitution of platlets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice[J]. Blood, 1995, 86(9):3308-3313.
[10] Neelis KJ, Dubbelman YD, Qingliang L, et al. Simultaneous administration of T PO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platlet and red cell reconstitution, alleviates neutropenia, and promotes the recovery of immature bone marrow cells[J]. Exp Hematol, 1997, 25(10):1084-1093.
[11] Neelis K J, Dubbelman YD, Wognum AW, et al. Lack of efficacy of thrombopoietin and granulocytecolony-stimulating factor after high dose total-body irradiation and autologous stem cell or bone marrow transplantation in rhesus monkeys[J]. Exp Hematol, 1997, 25(10):1094-1103.
[12] Shibuya K, Akahori H, Takahashi K, et al. Multilineage hematopoietic recovery by a single injection of pegylated recombinant megakaryocyte growth and development factor in myelosuppressed mice[J]. Blood, 1998, 91(1):37-45.
[13] Neelis KJ, Visser TP, Dimjati W, et al. A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells[J]. Blood, 1998, 92(5):1586-1597.

相似文献/References:

[1]包明月,刘玉龙.应用间充质干细胞治疗急性辐射损伤的研究现状与进展[J].国际放射医学核医学杂志,2016,40(1):65.[doi:10.3760/cma.j.issn.1673-4114.2016.01.013]
 Bao Mingyue,Liu Yulong.Recent advances in the application of mesenchymal stem cells for treatment of acute radiation injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):65.[doi:10.3760/cma.j.issn.1673-4114.2016.01.013]
[2]贺欣,储小飞,罗丹,等.穿心莲药物对辐射损伤效应影响的初步研究[J].国际放射医学核医学杂志,2015,39(5):375.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 005]
 he xin,chu xiaofei,luo dan,et al.exploration of andrographolide effects on radiation injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):375.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 005]
[3]路璐,张俊伶,李德冠,等.6 gy 137cs γ射线照射对小鼠造血功能损伤的动态观察研究[J].国际放射医学核医学杂志,2015,39(5):393.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 009]
 lu lu*,zhang junling,li deguan,et al.effects of 6 gy 137cs γ-irradiattion on the hematopoietic system of mice[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):393.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 009]
[4]刘惠惠,李险峰.放射性心脏损伤诊断和防治的临床研究进展[J].国际放射医学核医学杂志,2016,40(5):374.[doi:10.3760/cma.j.issn.1673-4114.2016.05.008]
 Liu Huihui,Li Xianfeng.Clinical research progress in diagnosis,prevention and treatment of radiation-induced heart disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):374.[doi:10.3760/cma.j.issn.1673-4114.2016.05.008]
[5]张倩如,李海涛,田红旗.小分子辐射防护药物的研究进展[J].国际放射医学核医学杂志,2016,40(5):394.[doi:10.3760/cma.j.issn.1673-4114.2016.05.012]
 Zhang Qianru,Li Haitao,Tian Hongqi.Small molecule compounds against radiation:research advances[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):394.[doi:10.3760/cma.j.issn.1673-4114.2016.05.012]
[6]王浩,沈秀,靳瑾,等.“四物汤”对辐射危害的辅助保护作用研究[J].国际放射医学核医学杂志,2015,39(2):121.[doi:10.3760/cma.j.issn.1673-4114.2015.02.004]
 Wang Hao,Shen Xiu,Jin Jin,et al.Protective activity of Siwu Decoction against radiation hazards[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):121.[doi:10.3760/cma.j.issn.1673-4114.2015.02.004]
[7]曹婉婷,李浣洋,陈雪英,等.正常组织在放射治疗中并发的迟发性损伤[J].国际放射医学核医学杂志,2015,39(3):260.[doi:10.3760/cma.j.issn.1673-4114.2015.03.016]
 Cao Wanting,Li Huanyang,Chen Xueying,et al.Late effects of radiotherapy on normal tissue[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):260.[doi:10.3760/cma.j.issn.1673-4114.2015.03.016]
[8]陈雪梅,周树云,范源,等.表没食子儿茶素没食子酸酯对131I辐射损伤所致甲减大鼠模型抗氧化体系的保护作用[J].国际放射医学核医学杂志,2015,39(4):311.[doi:10.3760/cma.j.issn.1673-4114.2015.04.009]
 Chen Xuemei,Zhou Shuyun,Fan Yuan,et al.Protection of antioxidant system of EGCG on the thyroid in rat model from 131I radiation damage[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):311.[doi:10.3760/cma.j.issn.1673-4114.2015.04.009]
[9]李德冠,路璐,吴红英,等.G-CSF联合SB203580对4Gy照射小鼠免疫系统的作用[J].国际放射医学核医学杂志,2014,38(4):216.[doi:10.3760/cma.j.issn.1673-4114.2014.04.002]
 Li Deguan,Lu Lu,Wu Hongying,et al.The effects of G-CSF combined with SB203580 on the immune system of mice received 4 Gy total body irradiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):216.[doi:10.3760/cma.j.issn.1673-4114.2014.04.002]
[10]张洪明,李险峰.放射性心脏损伤动物模型的研究进展[J].国际放射医学核医学杂志,2014,38(6):412.[doi:10.3760/cma.j.issn.1673-4114.2014.06.015]
 Zhang Hong-ming,Li Xian-feng.Progress in animal model of radiation-induced heart disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):412.[doi:10.3760/cma.j.issn.1673-4114.2014.06.015]

备注/Memo

备注/Memo:
收稿日期:2000-05-15。
作者简介:张军权(1967-),男,天津蓟县人,北京放射医学研究所博士研究生,主要研究放射病的治疗。;张浩(1968-),男,天津市人,北京放射医学研究所助理研究员,博士,主要研究方向:基因治疗。
更新日期/Last Update: 1900-01-01