[1]龚守良.一氧化氮与电离辐射[J].国际放射医学核医学杂志,2000,24(4):170-173.
　GONG Shou-liang.Nitric oxide and ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(4):170-173.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
24
期数:
2000年第4期
页码:
170-173
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Nitric oxide and ionizing radiation
作者:
龚守良
130021 吉林长春, 白求恩医科大学卫生部放射生物重点实验室
Author(s):
GONG Shou-liang
MH Radiobiology Research Unite, Norman Bethune University of Medical Sciences, Changchun 130021, China
关键词:
一氧化氮; 一氧化氮合酶; 电离辐射
Keywords:
nitric oxide; nitric oxide synthase; ionizing radiation
分类号:
R811.5
摘要:
一氧化氮(NO)的发现奠定了细胞信息传递的全新概念,即一个细胞产生的气体信号可穿透细胞膜调节另一个细胞的功能。NO具有独特的理化性质和生物学特性。体内NO是由L-精氨酸与O2在NO合酶(NOS)的作用下合成的。NOS主要有3种亚型,即内皮型(eNOS)、神经元型(nNOS)和诱导型(iNOS),它们受Ca2+/钙调蛋白、磷酸化和NO的调节。NO生物学作用广泛,且具有双向性。NO在体外可引起细胞的辐射敏感性,但在体内主要具有辐射防护作用。
Abstract:
The discovery of nitric oxide (NO) established a complete new concept on the cell signal transduction, i. e. the gas signal produced from one cell can pass through the cell membrane to regulate the functions of another cell. NO has unique physical and chemical natures. NO in vivo is synthesized by L-arginine and oxygen under the action of NO synthase (NOS). NOS mainly includes 3 kinds of subsets: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NO S (iNOS). These NOSs are regulated by Ca2+/calmodulin, phosphorylation and NO. The biological functions of NO are very wide and bidirect. NO might facilitate the radiosensitivity of cells in vitro, but display a radioprotective effect in vivo.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2000-05-15。
作者简介:龚守良(1945-),男,吉林长春人,白求恩医科大学卫生部放射生物重点实验室教授,博士生导师,主要从事辐射生物效应的研究。
更新日期/Last Update: 1900-01-01