[1]王劲,程亮,唐明灯,等.(N-[18F]氟甲基)胆碱的合成与质量控制[J].国际放射医学核医学杂志,2014,38(3):171-174.[doi:10.3760/cma.j.issn.1673-4114.2014.03.008]
　Wang Jin,Cheng Liang,Tang Mingdeng,et al.Synthesis and quality control of 18F-fluoromethyl choline[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):171-174.[doi:10.3760/cma.j.issn.1673-4114.2014.03.008]
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(N-[18F]氟甲基)胆碱的合成与质量控制(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第3期
页码:
171-174
栏目:
出版日期:
2014-05-25

文章信息/Info

Title:
Synthesis and quality control of 18F-fluoromethyl choline
作者:
王劲1;  程亮2;  唐明灯1;  庄达君2
1. 350014 福州, 福建省肿瘤医院核医学科;
2. 100022 北京, 北京安迪科电子有限责任公司
Author(s):
Wang Jin1;  Cheng Liang2;  Tang Mingdeng1;  Zhuang Dajun2
Department of Nuclear Medicine, Fujian Provincial Tumor Hospital, Fuzhou 350014, China
关键词:
回旋加速器; 质量控制; 氟甲基胆碱; 三氟甲烷磺酸银
Keywords:
Cyclotron; Quality control; Fluoromethyl choline; Ag-Triflate
DOI:
10.3760/cma.j.issn.1673-4114.2014.03.008
摘要:
目的 研究(N-[18F]氟甲基)胆碱(18F-FCH)在日本住友氟碳氮三合一合成装置上的全自动化合成与质量控制。方法 由日本住友回旋加速器生产出来的18F-与CH2Br2反应生成中间产物18FCH2Br,在高温下通过Ag-Triflate/C柱对其活性进行改造,生成活性更强的18FC2H4SO3CF3,再与N,N-二甲基乙醇胺在Sep-Pak C-18柱上常温进行反应,分别用酒精、注射用水、生理盐水淋洗串联在一起的Sep-Pak C-18柱和Sep-Pak CM柱后纯化得到成品。通过高效液相色谱法对合成产品的放化纯度进行检测。结果 合成产品的放化纯度>97%,未校正放化收率为27%,合成耗时38 min。结论 此种合成方法过程简单、操作容易、产品质量稳定,并且合成效率及放化纯度均有所提高。
Abstract:
Objective To research the automation synthesis and quality control of[18F]fluo-romethyl choline (18F-FCH) by automatic synthesis module from Japanese sumitomo corporation.Methods Intermediate product 18FCH2Br was produced by the reaction of CH2Br2 with 18F-which was made by sumit-omo cyclotron.18FC2H4SO3CF3 with a higher activity was generated by modifying the activities of 18FCH2Br through the Ag-Triflate/C column at high temperature.18FC2H4SO3CF3 reacted with N,N-dimethyl ethanolamine on Sep-Pak C-18 column at room temperature and the products were purified through wash-ing the Sep-Pak C-18 column and Sep-Pak CM column in series with alcohol,water and physiological saline injector respectively.The purity of the final products was detected by high performance liquid chro-matography.Results The radiochemical purity of 18F-FCH was above 97%,the uncorrected radiochemical yield was 27%,and the synthesis process last for 38 min.Conclusion This synthesis method has more advantages,such as easier operation,higher yields,shorter synthesis time,more stable products with a higher radiochemical purity.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2013-07-16。
基金项目:国家临床重点专科建设项目
通讯作者:王劲,Email:wj810613@163.com
更新日期/Last Update: 1900-01-01