[1]翟贺争,刘辉,李卫星,等.应用Detector729的两种IMRT剂量验证方法比较[J].国际放射医学核医学杂志,2014,38(5):285-288.[doi:10.3760/cma.j.issn.1673-4114.2014.05.002]
　Zhai He-zheng,Liu Hui,Li Wei-xing,et al.Comparison of two dosimetric verification methods of IMRT using Detector729[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(5):285-288.[doi:10.3760/cma.j.issn.1673-4114.2014.05.002]
点击复制

应用Detector729的两种IMRT剂量验证方法比较(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第5期
页码:
285-288
栏目:
出版日期:
2014-09-25

文章信息/Info

Title:
Comparison of two dosimetric verification methods of IMRT using Detector729
作者:
翟贺争1;  刘辉2;  李卫星3;  齐伟华4;  袁继龙2;  李明生2;  阮书州1;  王小春1
1. 中国医学科学院放射医学研究所, 天津市放射医学与分子核医学重点实验室, 天津, 300192;
2. 中国疾病预防控制中心辐射防护与核安全医学所, 北京, 100088;
3. 山西省太原市疾病预防控制中心, 030012;
4. 中国人民解放军军事医学科学院附属医院, 北京, 100071
Author(s):
Zhai He-zheng1;  Liu Hui2;  Li Wei-xing3;  Qi Wei-hua4;  Yuan Ji-long2;  Li Ming-sheng2;  Ruan Shu-zhou1;  Wang Xiao-chun1
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300192, China
关键词:
质量控制; 放射疗法; 调强适形; Detector729; 剂量验证
Keywords:
Quality control; Radiotherapy; intensity-modulated; Detector729; Dosimetric verification
DOI:
10.3760/cma.j.issn.1673-4114.2014.05.002
摘要:
目的 比较、分析Detector729用于IMRT质量控制的两种剂量验证方法。方法 用Pinnacle 8.0 m计划系统对13例肿瘤患者做IMRT治疗计划,根据Detector729的CT扫描图像,分别做出实际机架角和0°机架角的验证计划,并在Varian 23EX加速器上实施剂量验证;依据剂量偏差(距离偏差)分别为3%(3 mm)、3%(4 mm)和4%(4 mm)的判定标准,得到两种验证方法的γ验证通过率,采用SAS统计学软件对验证结果进行分析。结果 Detector729两次测量的重复性均<0.3%;应用Detector729对IMRT实际机架角验证3%(3 mm)、3%(4 mm)和4%(4 mm)的平均通过率分别为91.2%、92.4%和95.6%,较0°机架角计划验证通过率分别低了2.2%(t=-2.04,P=0.053)、2.2%(t=-2.02,P=0.055)和1.4%(t=-1.97,P=0.060),两种剂量验证方法的通过率差异无统计学意义。结论 Detector729测量结果可信、准确;实际照射剂量验证和0°机架角剂量验证均与验证计划剂量分布基本一致;建议医疗机构采取符合实际治疗情况的剂量验证方法。
Abstract:
Objective To compare and analyze the dose distribution of IMRT between fixed-gantry and unfixed-gantry dosimetric verification. Methods Thirteen patients treated by IMRT were chosen randomly for this study. For each case, 2 different plans (fixed-gantry plan and unfixed-gantry plan)were worked out with Pinnacle 8.0 m planning system. The dose verification for each plan was carried out with Varian 23EX by using Detector729 with the octagonal phantom OCTAVIUS. The verification results of the dose distribution between the treatment planning system calculation and the measurement were done by the gamma analysis quantization with dose difference and distance to agreement of 3% (3 mm), 3% (4 mm)and 4% (4 mm)respectively, and the data were analyzed by Statistical Analysis System. Results The repeatability of Detector729 was within 0.3%. According to the gamma analysis, the overall average passing rate of unfixed-gantry verification for the dosimetric deviation of 3% (3 mm), 3% (4 mm)and 4% (4 mm)were 91.2%, 92.4%and 95.6%, which were slightly lower compared with the passing rate of fixed-gantry verification of 2.2% (t=-2.04, P=0.053), 2.2% (t=-2.02, P=0.055)and 1.4% (t=-1.97, P=0.060)respectively, and the difference between the two verification methods was not statistically significant. Conclusions The Detector729 is a reliable and accurate dosimeter. The two dosimetric verification methods of IMRT by using Detector729 are efficient and valuable. The radiotherapy department should select suitable and available dosimetric verification method for radiotherapy.

参考文献/References:

[1] Low DA,Moran JM,Dempsey JF,et al.Dosimetry tools and techniques for IMRT[J].Med Phys,2011,38(3):1313-1338.
[2] Van Esch A,Clermont C,Devillers M,et al.On-line quality assurance of rotational radiotherapy treatment delivery by means of a 2D ion chamber array and the Octavius phantom[J].Med Phys,2007,34(10):3825-3837.
[3] Syamkumar SA,Padmanabhan S,Sukumar P,et al.Characterization of responses of 2d array seven29 detector and its combined use with octavius phantom for the patient-specific quality assurance in rapidarc treatment delivery[J].Med Dosim,2012,37(1):53-60.
[4] Poppe B,Blechschmidt A,Djouguela A,et al. Two-dimensional ionization chamber arrays for IMRT plan verification[J].Med Phys,2006,33(4):1005-1015.
[5] Hussein M,Adams EJ,Jordan TJ,et al.A critical evaluation of the PTW 2D-ARRAY seven29 and OCTAVIUS Ⅱ phantom for IMRT and VMAT verification[J].J Appl Clin Med Phys,2013,14(6):274-292.
[6] Low DA,Harms WB,Mutic S,et al.A technique for the quantitative evaluation of dose distributions[J]. Med Phys,1998,25(5):656-661.
[7] Low DA,Dempsey JF. Evaluation of the gamma dose distribution comparison method[J]. Med Phys,2003,30(9):2455-2464.
[8] Fraass B,Doppke K,Hunt M,et al.American Association of Physicists in Medicine Radiation Therapy Committee Task Group 53:quality assurance for clinical radiotherapy treatment planning[J].Med Phys,1998,25(10):1773-1829.
[9] Saminathan S,Manickam R,Chandraraj V,et al. Dosimetric study of 2D ion chamber array matrix for the modern radiotherapy treatment verification[J].J Appl Clin Med Phys,2010,11(2):116-127.
[10] Spezi E,Angelini AL,Romani F,et al.Characterization of a 2D ion chamber array for the verification of radiotherapy treatments[J].Phys Med Biol,2005,50(14):3361-3373.
[11] International Electrotechnical Commission.Medical electrical equipment-Dosimeters with ionization chambers as used in radio-therapy Paperback[S].Geneva:IEC,2011.
[12] Shimohigashi Y,Araki F,Tominaga H,et al.Angular dependence correction of MatriXX and its application to composite dose verification[J].J Appl Clin Med Phys,2012,13(5):198-214.
[13] Bayouth JE.Siemens multileaf collimator characterization and quality assurance approaches for intensity-modulated radiotherapy[J].Int J Radiat Oncol Biol Phys,2008,71(Suppl 1):S93-97.

相似文献/References:

[1]张奇洲,李毓斌,李肖红,等.11C-乙酸盐的自动化合成影响因素的考察及质量控制[J].国际放射医学核医学杂志,2016,40(1):6.[doi:10.3760/cma.j.issn.1673-4114.2016.01.002]
　Zhang Qizhou,Li Yubin,Li Xiaohong,et al.Study of the automated synthesis influence factors and quality control of 11C-acetate[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):6.[doi:10.3760/cma.j.issn.1673-4114.2016.01.002]
[2]李景涛,邓垒,张文珏,等.广泛期小细胞肺癌胸部IMRT后发生放射性肺炎的危险因素分析[J].国际放射医学核医学杂志,2016,40(2):100.[doi:10.3760/cma.j.issn.1673-4114.2016.02.003]
　Li Jingtao,Deng Lei,Zhang Wenjue,et al.Risk factor analysis for predicting radiation pneumonitis in extensive stage small cell lung cancer patients receiving IMRT thoracic radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):100.[doi:10.3760/cma.j.issn.1673-4114.2016.02.003]
[3]刘佳,高刚,朴春南,等.调节肿瘤放射敏感性的miRNAs研究进展[J].国际放射医学核医学杂志,2016,40(2):159.[doi:10.3760/cma.j.issn.1673-4114.2016.02.015]
　Liu Jia,Gao Gang,Piao Chunnan,et al.Progress of microRNAs in regulating tumor radiation sensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):159.[doi:10.3760/cma.j.issn.1673-4114.2016.02.015]
[4]陈晓艳,张江虹,邵春林.STAT3与辐射敏感相关性的研究进展[J].国际放射医学核医学杂志,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
　Chen Xiaoyan,Jianghong,Shao Chunlin.Research progresses of correlation between STAT3 and radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
[5]赵德云,李百龙.植物提取物防治放射性肺损伤的现状与展望[J].国际放射医学核医学杂志,2016,40(3):208.[doi:10.3760/cma.j.issn.1673-4114.2016.03.010]
　Zhao Deyun,Li Bailong.Protective and therapeutic effects of plant extracts on radiation-induced lung injury:present status and future prospects[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):208.[doi:10.3760/cma.j.issn.1673-4114.2016.03.010]
[6]田琦,蒋宁一,郑丽.265例精细个体化131I治疗Graves甲亢的疗效观察[J].国际放射医学核医学杂志,2016,40(4):259.[doi:10.3760/cma.j.issn.1673-4114.2016.04.004]
　Tian Qi,Jiang Ningyi,Zheng Li.Therapeutic effect of fine individual 131I treatment on Graves disease hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):259.[doi:10.3760/cma.j.issn.1673-4114.2016.04.004]
[7]贺小红,周新韩,高明勇,等.模型模拟修改部分扫描参数加速MR扫描的方法可行性探讨[J].国际放射医学核医学杂志,2016,40(4):267.[doi:10.3760/cma.j.issn.1673-4114.2016.04.006]
　He Xiaohong,Zhou Xinhan,Gao Mingyong,et al.Feasibility of accelerating MR scan by modifying part of scanning parameters：a phantom simulation study[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):267.[doi:10.3760/cma.j.issn.1673-4114.2016.04.006]
[8]邓大平,卢峰,孙洪强,等.颅脑肿瘤放射治疗时射野外器官吸收剂量体模法测量与分析[J].国际放射医学核医学杂志,2016,40(4):272.[doi:10.3760/cma.j.issn.1673-4114.2016.04.007]
　Deng Daping,Lu Feng,Sun Hongqiang,et al.Test and analysis of out-of-field organ dose in intracranial tumor radiotherapy using phantom[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):272.[doi:10.3760/cma.j.issn.1673-4114.2016.04.007]
[9]卢顺琦,吴锦海,刘海宽,等.上海市数字化乳腺x射线摄影装置质量控制检测分析[J].国际放射医学核医学杂志,2015,39(5):381.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 006]
　lu shunqi,wu jinhai,liu haikuan,et al.Quality analysis of digital mammography facilities in shanghai[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(5):381.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 006]
[10]拓飞,张庆,张京,等.2014年度全国放射性核素γ能谱分析质量控制比对[J].国际放射医学核医学杂志,2015,39(5):401.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 011]
　tuo fei,zhang qing,zhang jing,et al.nationwide intercomparison for radionuclide analyses through γ-spectrometry method in 2014[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(5):401.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 011]
[11]何垠波,周莉,徐庆丰,等.网络管理对肿瘤放疗流程的优化[J].国际放射医学核医学杂志,2012,36(3):182.[doi:10.3760/cma.j.issn.1673-4114.2012.03.016]
　HE Yin-bo,ZHOU Li,XU Qing-feng,et al.Optimization of the radiotherapy procedure using network management[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(5):182.[doi:10.3760/cma.j.issn.1673-4114.2012.03.016]
[12]江波,刘振宅,徐晓.调强放疗中有关多叶准直器的质量保证与质量控制[J].国际放射医学核医学杂志,2006,30(6):378.
　JIANG Bo,LIU Zhen-zhai,XU Xiao.Quality assurance and quality control of multileaf collimator in intensity modulated radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(5):378.
[13]李克新,鞠永健.电子射野影像系统在放疗中的应用进展[J].国际放射医学核医学杂志,2018,(5):468.[doi:10.3760/cma.j.issn.1673-4114.2018.05.015]
　Li Kexin,Ju Yongjian.Advances in the application of electronic portal imaging device in radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(5):468.[doi:10.3760/cma.j.issn.1673-4114.2018.05.015]

备注/Memo

备注/Memo:
收稿日期:2014-01-20。
基金项目:国家自然科学基金(81272511);中国医学科学院放射医学研究所基金(所开1427)
通讯作者:王小春(Email:wxc3188@126.com)
更新日期/Last Update: 1900-01-01