[1]池翠萍.生物学系统内检测自由基方法的研究进展及其意义[J].国际放射医学核医学杂志,2009,33(4):252-255.[doi:10.3760/cma.j.issn.1673-4114.2009.04.019]
 CHI Cui-ping.Progress in measurement of free radicals in biological systems[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):252-255.[doi:10.3760/cma.j.issn.1673-4114.2009.04.019]
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生物学系统内检测自由基方法的研究进展及其意义(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第4期
页码:
252-255
栏目:
技术与方法
出版日期:
1900-01-01

文章信息/Info

Title:
Progress in measurement of free radicals in biological systems
作者:
池翠萍
中国辐射防护研究院放射医学与环境医学所, 太原, 030006
Author(s):
CHI Cui-ping
Department of Radiation Medicine and Environmental Meaicme, China Institute for Radiation Protection, Taiyuan 030006, China
关键词:
自由基活性氧辐射损伤电子自旋共振谱学
Keywords:
Free radicalsReactivfe oxygen speciesRadiation damageElectron spin resonance spectroscopy
DOI:
10.3760/cma.j.issn.1673-4114.2009.04.019
摘要:
活性氧等自由基与神经变性性疾病、糖尿病、辐射损伤等多种病理过程的发展相关。检测自由基技术在辐射防护和辐射生物效应方面具有重要的实际意义。该文综述了建立在电子自旋共振(ESR)基础上的各种自由基检测技术,同时介绍了新近建立的利用免疫电子自旋捕捉技术检测DNA和蛋白质大分子自由基的方法。
Abstract:
Free radicals generation and oxidative stress are involved in many pathological processes including neuro-degenerated diseases, diabetes, tumorigenesis and radiation damage. Measurement of free radicals is of importance in the field of radiation protection and radiation damage. The electron spinning resonance (ESR) techniques for measurement of free radicals in biological systems are summarized according to the literature and the author’s research work in this review. The recent emerging imrauno-spin trapping method for analysis of protein radicals and D N A radicals is also introduced.

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备注/Memo

备注/Memo:
收稿日期:2009-02-22。
更新日期/Last Update: 1900-01-01