[1]王珍芳,万卫星.食管癌中18F-氟脱氧葡萄糖摄取和葡萄糖转运蛋白1表达的相关性研究[J].国际放射医学核医学杂志,2009,33(1):18-21.[doi:10.3760/cma.j.issn.1673-4114.2009.01.018]
 WANG Zhen-fang,WAN Wei-xing.Research of the relationship between expression of glucose transporter-1 and 18F-fluorodeoxyglucose uptake in esophgeal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(1):18-21.[doi:10.3760/cma.j.issn.1673-4114.2009.01.018]
点击复制

食管癌中18F-氟脱氧葡萄糖摄取和葡萄糖转运蛋白1表达的相关性研究(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第1期
页码:
18-21
栏目:
分子核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Research of the relationship between expression of glucose transporter-1 and 18F-fluorodeoxyglucose uptake in esophgeal cancer
作者:
王珍芳 万卫星
无锡市第四人民医院、苏州大学附属第四医院核医学科, 苏州 214062
Author(s):
WANG Zhen-fang WAN Wei-xing
Department of Nuclear Medicine, the Fourth People’s Hospital of Wuxi, the Fourth Hospital Affiliated to Soochow University, Wuxi 214062, China
关键词:
食管肿瘤氟脱氧葡萄糖F18葡萄糖转运蛋白1
Keywords:
Esophgeal neoplasmsFluorodeoxyglucose F18Glucose transport protein-1
DOI:
10.3760/cma.j.issn.1673-4114.2009.01.018
摘要:
食管癌的发生和发展涉及多个基因、分子水平的异常,是多个因素参与、共同作用的结果。18F-氟脱氧葡萄糖(18F-FDG) PET检测肿瘤细胞糖摄取在肿瘤诊断、分期、疗效评价、预后判断等方面的应用越来越广泛,而葡萄糖转运蛋白1(Glut-1)在食管癌肿瘤细胞葡萄糖摄取和细胞增殖过程中起重要作用。
Abstract:
The occurrence and development of esophgeal cancer is a result of many factors that effect each other, which involved disorders of multiple genes and levels of molecular. The application of 18F-fluorodeoxyglucose (18F-FDG) PET detecting tumor cells glucose uptaked is more and more generally in the tumor diagnosis, staging, curative effect evaluation, and prognosis judgement and so on, glucose transporter-1 has an important role in the esophgeal cancer cells glucose uptaked and cells proliferation process.

参考文献/References:

[1] Jemal A,Siegel R,Ward E,et al.Cancer statistics,2007.CA Cancer J Clin,2007,57(1):43-66.
[2] Scheepers A,Joost HG,Schurmann A.The glucose transporter families SGLT and GLUT:molecular basis of normal and aberrant function.JPEN J Parenter Enteral Nutr,2004,28(5):364-371.
[3] Wu X,Freeze HH.GLUT14,a duplicon of GLUT3,is specifically expressed in testis as alternative splice forms.Genomies,2002,80(6):553-557.
[4] Noto Y,Iwazaki A,Nagao J,et al.Altered N-glycosylation of glucose transporter-1 associated with radiation-induced tumorigenesis of human cell hybrids.Biochem Biophys Res Commun,1997,240(2):395-398.
[5] Kunkel M,Beichert TE,Benz P,et al.Overexpression of Glut1 and increased glucose metabolism in turrnors are associated with a poor prognosis in patients with oral squamous cell carcinoma.Cancer,2003,97(4):1015-1024.
[6] 王京弟,高辉,等.GLUT1 mRNA在食管癌中的表达及临床意义.中国现代医学杂志,2002,12(12):30-32.
[7] 穆殿斌,王绍平,杨文锋,等.食管癌组织中葡萄糖转运蛋白1表达和Ki-67抗原标记指数与PET/CT显示的18F-FDG摄取水平相关.中华肿瘤杂志,2007,29(1):30-33.
[8] Mintz A,Kim SH,Alavi A,et al.A genetic model of esophageal cancer accurately portrays clinical FDG uptake[J/OL].J Nucl Med,2006,47(Suppl 1):431P[2008-04-12].http://jnumedmtg.snmjournals.org/cgi/content/abstract/47/suppl_1/431P?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=47&-firs-tpage=431p&resourcetype=HWCIT.
[9] Joost HG,Thorens B.The extended GLUT-family of sugar/polyol transport facilitators:nomenclature,sequence characteristics,and potential function of its novel members (review).Mol Membr Biol,2001,18(4):247-256.
[10] Doki Y,Takachi k.Ishikawa O,et al.Reduced tumor vessel density and high expression of glucose transporter 1 suggest tumor hypoxia of squamous cell carcinoma of the esophagus surviving after radiotherapy.Surgery,2005,137(5):536-544.
[11] Kato H,Takita J,Miyazaki T,et al.Correlation of 18-F-fluorodeoxyglucose (FDG) accumulation with glucose transporter (Glut-1) expression in esophageal squamous cell carcinoma.Anticancer Res,2003,23(4):3263-3272.
[12] Schwurtzenberg-Bur-Yoseph F,Armoni M,Kamieli E.The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression.Cancer Res,2004,64(7):2627-2633.
[13] Ravazoula P,Batistatou A,Aletra C,et al.Immunohistochemical expression of glucose transporter Glut1 and cyclin D1 in breast carcinomas with negative lymph nodes.Eur J Gynaecol Oncol,2003,24(6):544-546.
[14] Younes M,Ertan A,Lechago LV,et al.Human erythroeyte glucose transporter (Glut1) is immunohistochemically detected as a late event during malignant progression in Barrett’s metaplasia.Cancer Epidemiol Biomarkers Prev,1997,6(5):303-305.
[15] Kato H,Takita J,Miyazaki T,et al.Glut-1 glucose transporter expression in esophageal squamous cell carcinoma is associated with tumor aggressiveness.Anticancer Res,2002,22(5):2635-2639.
[16] Driessen A,Alaerts H,Riet V,et al.Correlation of positron emission tomography (PET)-avidity in esophageal and cardiac adenocarcinomas with hypoxia-related biomarkers[J/OL].J Clin Oncol,2004.22(Suppl 14):4045[2008-04-12].http://mceting.ascopubs.org/cgi/content/abstract/22/14_suppl/4045?maxtoshow=&HITS=20&hits=20&RESULTFORMAT=&fulhext=2004%2C22%2CSuppl+14%2C4045&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT.
[17] Guo H,Zhu H,Xi Y,et al.Diagnostic and prognostic value of 18F-FDG PET/CT for patients with suspected recurrence from squamous cell carcinoma of the esophagus.J Nucl Med,2007,48(8):1251-1258.
[18] van Westreenen HL,Plukker JT,Cobben DC,et al.Proguostic value of the standardized uptake value in esophageal cancer.AJR Am J Roentgenol.,2005,185(2):436-440.
[19] Aloj L,Caraco C,Jagoda E,et al.Glut-1 and hexokinase expression:relationship with 2-fluoro-2-deoxy-D-glucese uptake in A431 and T47D cells in culture.Cancer Res,1999,59(18):4709-4714.

相似文献/References:

[1]史文杰,孟召伟,谭建.基于Deauville标准探讨18F-FDG PET/CT在霍奇金淋巴瘤复发诊断中的应用价值[J].国际放射医学核医学杂志,2016,40(2):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
 Shi Wenjie,Meng Zhaowei,Tan Jian.Value of 18F-FDG PET/CT on diagnosis of Hodgkin lymphoma recurrence using Deauville criterion[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
[2]尤阳,轩昂,张杰,等.淋巴瘤患者大脑静息葡萄糖代谢改变[J].国际放射医学核医学杂志,2016,40(4):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
 You Yang,Xuan Ang,Zhang Jie,et al.Changes in resting-state brain glucose metabolism in patients with lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
[3]王朋,崔邦平,代文莉,等.18F-FDG PET/CT在前列腺癌中的应用进展[J].国际放射医学核医学杂志,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
 Wang Peng,Cui Bangping,Dai Wenli,et al.Progress in the application of 18F-FDG PET/CT in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
[4]许靖,李肖红,秦永德,等.帕金森病脑部葡萄糖代谢和脑多巴胺转运体PET显像特点的临床研究[J].国际放射医学核医学杂志,2016,40(5):338.[doi:10.3760/cma.j.issn.1673-4114.2016.05.003]
 Xu Jing,Li Xiaohong,Qin Yongde,et al.Clinical study of brain glucose metabolism and brain dopamine transporter PET imaging in patients with Parkinson’s disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):338.[doi:10.3760/cma.j.issn.1673-4114.2016.05.003]
[5]曹登敏,林美福,陈文新,等.继发性骨淋巴瘤的18F-FDG PET/CT影像学表现[J].国际放射医学核医学杂志,2016,40(6):403.[doi:10.3760/cma.j.issn.1673-4114.2016.06.001]
 Cao Dengmin,Lin Meifu,Chen Wenxin,et al.Analysis on 18F-FDG PET/CT imaging characteristics in secondary bone lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):403.[doi:10.3760/cma.j.issn.1673-4114.2016.06.001]
[6]张莹莹,王振光,武凤玉,等.特发性肺间质纤维化HRCT病变区与非病变区18F-FDG PET/CT表现分析[J].国际放射医学核医学杂志,2016,40(6):414.[doi:10.3760/cma.j.issn.1673-4114.2016.06.003]
 Zhang Yingying,Wang Zhenguang,Wu Fengyu,et al.18F-FDG PET/CT imaging analysis of regions with abnormal and normal pulmonary parenchyma on high resolution CT in idiopathic pulmonary fibrosis patients[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):414.[doi:10.3760/cma.j.issn.1673-4114.2016.06.003]
[7]张毓艺,姚稚明.18F-FDG PET/CT对非小细胞肺癌淋巴结分期诊断价值的研究进展[J].国际放射医学核医学杂志,2016,40(6):447.[doi:10.3760/cma.j.issn.1673-4114.2016.06.009]
 Zhang Yuyi,Yao Zhiming.The progress of 18F-FDG PET/CT in the diagnosis of N-staging of non-small cell lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):447.[doi:10.3760/cma.j.issn.1673-4114.2016.06.009]
[8]郝新忠,武志芳,武萍,等.SAPHO综合征18F-FDG PET/CT显像和临床分析[J].国际放射医学核医学杂志,2015,39(6):447.[doi:10.3760/cma.j.issn.1673-4114.2015.06.003]
 Hao Xinzhong,Wu Zhifang,Wu Ping,et al.18F-FDG PET/CT imaging and clinical features of SAPHO syndrome[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):447.[doi:10.3760/cma.j.issn.1673-4114.2015.06.003]
[9]邱琳,陈跃,黄占文,等.18F-FDG PET/CT脑显像在新生儿缺血缺氧性脑病诊断及治疗后评估中的临床研究[J].国际放射医学核医学杂志,2015,39(6):452.[doi:10.3760/cma.j.issn.1673-4114.2015.06.004]
 Qiu Lin,Chen Yue,Huang Zhanwen,et al.Clinical research on using 18F-FDG PET/CT brain imaging in the diagnosis of and therapeutic effect evaluation in neonatal hypoxic-ischemic encephalopathy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):452.[doi:10.3760/cma.j.issn.1673-4114.2015.06.004]
[10]周文兰,吴湖炳,韩彦江,等.18F-FDG PET/CT对骨骼孤立性高代谢病灶的初步诊断价值[J].国际放射医学核医学杂志,2015,39(1):14.[doi:10.3760/cma.j.issn.1673-4114.2015.01.005]
 Zhou Wenlan,Wu Hubing,Han Yanjiang,et al.Preliminary study of 18F-FDG PET/CT in the diagnosis of solitary hypermetabolic lesion of bone[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):14.[doi:10.3760/cma.j.issn.1673-4114.2015.01.005]
[11]李菲,黄俊星,张俊.18F-FDG PET/CT在食管癌中的临床应用[J].国际放射医学核医学杂志,2016,40(4):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
 Li Fei,Huang Junxing,Zhang Jun.The clinical application of 18F-FDG PET/CT in esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
[12]李生栩,唐明灯,林端瑜,等.18F-FDG PET/CT在胸段食管鳞癌淋巴结转移中的诊断价值[J].国际放射医学核医学杂志,2016,40(6):408.[doi:10.3760/cma.j.issn.1673-4114.2016.06.002]
 Li Shengxu,Tang Mingdeng,Lin Duanyu,et al.Value of 18F-FDG PET/CT in detecting metastatic lymph nodes of thoracic esophageal squamous cell carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):408.[doi:10.3760/cma.j.issn.1673-4114.2016.06.002]
[13]谢彦婷,郑容.18F-FDG PET/CT在食管癌放疗中的应用[J].国际放射医学核医学杂志,2013,37(1):42.[doi:10.3760/cma.j.issn.1673-4114.2013.01.012]
 XIE Yan-ting,ZHENG Rong.The application of 18F-FDG PET/CT in the radiotherapy of esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):42.[doi:10.3760/cma.j.issn.1673-4114.2013.01.012]
[14]杨吉刚,李春林.18F-氟脱氧葡萄糖PET及PET-CT在食管癌中的[J].国际放射医学核医学杂志,2007,31(1):31.
 YANG Ji-gang,LI Chun-lin.Application of 18F-fluorodeoxyglucose PET and PET-CT imaging in esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):31.

备注/Memo

备注/Memo:
收稿日期:2008-04-24。
通讯作者:万卫星(E-mail:wwxjs@126.com)
更新日期/Last Update: 1900-01-01