[1]杨宝军,李险峰,陆克义,等.99Tcm-二亚乙基三胺五乙酸与99Tcm-奥曲肽眼眶显像在甲状腺相关性眼病中的对比研究[J].国际放射医学核医学杂志,2009,33(1):22-25.[doi:10.3760/cma.j.issn.1673-4114.2009.01.022]
　YANG Bao-jun,LI Xian-feng,LU Ke-yi,et al.A comparative study of 99Tcm-diethylene triaminepentaacetic acid and 99Tcm-octreotide orbital scan in thyroid associated ophthalmopathy[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(1):22-25.[doi:10.3760/cma.j.issn.1673-4114.2009.01.022]
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99Tcm-二亚乙基三胺五乙酸与99Tcm-奥曲肽眼眶显像在甲状腺相关性眼病中的对比研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第1期
页码:
22-25
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
A comparative study of 99Tcm-diethylene triaminepentaacetic acid and 99Tcm-octreotide orbital scan in thyroid associated ophthalmopathy
作者:
杨宝军;  李险峰;  陆克义;  赵德善;  李思进
山西医科大学第一医院核医学科, 太原 030001
Author(s):
YANG Bao-jun;  LI Xian-feng;  LU Ke-yi;  ZHAO De-shah;  LI Si-jin
Department of Nuclear Medicine, First Hospitial of Shanxi Medical University, Taiyuan 030001, China
关键词:
99Tcm-五乙酸盐99Tcm-奥曲肽; 体层摄影术; 发射型计算机; 单光子; GRAVES眼病; 眼眶
Keywords:
Technetium Tc 99m pentetate; Technetium Tc 99m octreotide; Tomography; emission computed sinsic-photon; Graves ophthaimopathy; Orbit
DOI:
10.3760/cma.j.issn.1673-4114.2009.01.022
摘要:
目的 通过对比99Tcm-二亚乙基三胺五乙酸(99Tcm-DTPA)与99Tcm-奥曲肽(99Tcm-OCT)眼眶显像,比较两种显像方法在评估甲状腺相关眼病(TAO)患者眼部炎性反应活动度中的临床价值。方法 26例TAO患者依据临床活动度评分(CAS)标准分为炎性反应活动组16例、非炎性活动组10例,另有14名正常志愿者作为对照组。静脉注射99Tcm-DTPA 740 MBq,0.5h后行眼眶平面及体层显像,隔日同一患者静脉注射99Tcm-OCT740MBq,1-2h后行眼眶平面及体层显像。获取各组两种眼眶显像剂的摄取率。对两种显像方法获得的半定量指标UROCT和URDTPA进行配对t检验并分别与CAS评分进行Spearman相关性分析。结果 两种显像剂的眼眶摄取率未见明显差异(t=0.075,P>0.05)。两种显像剂的眼眶摄取率(UROCT、URDTPA)与患者CAS评分之间具有很好的相关性(99Tcm-DTPA:r=0.835,P<0.001;99Tcm-OCT:r=0.912,P<0.001)。结论 99Tcm-DTPA与99Tcm-OCT的眼眶显像有较好的一致性,证明99Tcm-DTPA眼眶显像是一种可行的、并可能成为一种很有发展前景的评价TAO炎性反应活动度的新方法。
Abstract:
Objective Through a comparative study of 99Tcm-diethylenetriaminepentaacetic acid (99Tcm-DTPA) and 99Tcm-octreotide (99Tcm-OCT) SPECT orbital scan, evaluated the clinic significance of two imaging of estimation activity in thyroid associated ophthalmopathy (TAO). Methods Acording to the clinnic activity score (CAS), 26 TAO patients were divided into two groups:active group (CAS≥3) and inactive group (CAS<3), 14 volunteers (control group) participates this study. Orbit scan were completed after intravenously injection with 99Tcm-DTPA 740 MBq and 99Tcm-OCT (every other day). Obtaining the uptake ratio (UR) of two kinds of orbit scans. The statistical analyses included Paired-samples t test analysis of variance and Spearman regression analysis. Results There is no statistically significance between the two methods in UR (t=0.075, P>0.05). There is a statistically significant correlation was found between CAS and the uptake ratios(99Tcm-DTPA:r=0.835, P<0.001; 99Tcm-OCT:r=0.912, P<0.001). Conclusions There is a good uniformity between 99Tcm-DTPA and 99Tcm-OCT orbital scan; 99Tcm-DTPA is a feasible and maybe a new promising estimation method of activity in the patients with TAO.

参考文献/References:

[1] Weetman AP.Graves’ disease.N Engl J Med,2000,343(17):1236-1248.
[2] Pappa A,Lawson JM,Calder V,et al.T cells and fibroblasts in affected extraoculas muscles in early and late thyroid associated ophthalmopathy.Br J Ophthalmol,2000,84(5):517-522.
[3] 李险峰,段练,陆克义,等.甲状腺功能亢进突眼患者99mTc-奥曲肽显像一例.放射学实践,2005,20(5):465-466.
[4] 段炼,李险峰,陆克义,等.99Tcm-奥曲肽眼眶显像在甲状腺相关眼病中的临床应用.中华眼科杂志,2006(12).
[5] Moncayo R,Baldissera I,Decristoforo C,et al.Evaluation of immunological mechanisms mediating thyroid-associated ophthalmopathy by radionuclide imaging using the somatestatin analog 111In-octreotide.Thyroid,1997,7(1):21-29.
[6] Burggasser G,Hurtl I,Hauff W,et al.Orbital seintigraphy with the somatostatin receptor tracer 99mTc-P829 in patients with Graves’ disease.J Nucl Med,2003,44(10):1547-1555.
[7] Kainz H,Bale R,Donnemiller E,et al.Image fusion analysis of 99mTc-HYNIC-octreotide scintigraphy and CT/MRI in patients with thyroid-associated orbitopathy:the importance of the lacrimal gland.Eur J Nucl Med Mol Imaging,2003,30(8):1155-1159.
[8] Krassas GE,Doumas A,Kaltsas T,et al.Somatestatin receptor scintigraphy before and after treatment with somatestatin analogues in patients with thyroid eye disease.Thyroid,1999,9(1):47-52.
[9] Galuska L,Leovey A,Szucs-Farkas Z,et al.SPECT using 99mTc-DTPA for the assessment of disease activity in Graves’ ophthalmopathy:a comparison with the results from MRI.Nucl Med Commun,2002,23(12):1211-1216.

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备注/Memo

备注/Memo:
收稿日期:2008-08-10。
通讯作者:李险峰(E-mail:lixianfeng-lxf@263.net)
更新日期/Last Update: 1900-01-01