[1]宁艳丽,晋建华,张宏,等.SPM5软件分析癫痫患者脑PET图像的应用研究[J].国际放射医学核医学杂志,2009,33(1):26-29.[doi:10.3760/cma.j.issn.1673-4114.2009.01.026]
　NING Yan-li,dIN Jian-hua,ZHANG Hong,et al.Application study of SPM5 in analysis of PET imaging for epilepsy patient[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(1):26-29.[doi:10.3760/cma.j.issn.1673-4114.2009.01.026]
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SPM5软件分析癫痫患者脑PET图像的应用研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第1期
页码:
26-29
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Application study of SPM5 in analysis of PET imaging for epilepsy patient
作者:
宁艳丽1;  晋建华1;  张宏2;  田梅2;  姚琼2;  占宏伟1;  赵春雷1;  许唯1;  叶小娟1;  李晶1
1. 山西医科大学第一医院核医学科, 太原 030001;
2. 浙江大学附属第二医院PET中心, 杭州 310009
Author(s):
NING Yan-li1;  dIN Jian-hua1;  ZHANG Hong2;  TIAN Mei2;  YAO Qiong2;  LI Jing1;  ZHAN Hong-wei1;  ZHAO CHUN-lei1;  XU Wei1;  YE Xiao-juan1
1. Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China;
2. Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang Medical University, Hangzhou 310009, China
关键词:
癫痫; 正电子发射体层摄影术; 统计参数图5
Keywords:
Epilepsy; Positron-emission tomography; Statistical parametric mapping
DOI:
10.3760/cma.j.issn.1673-4114.2009.01.026
摘要:
目的 探讨统计参数图5(SPM5)软件及不同参数设定在癫痫患者脑PET图像分析中的应用价值。方法 癫痫病例组17例,均经临床综合确诊为癫痫,对照组为17例同期健康体检者,对研究对象行18F-氟脱氧葡萄糖PET脑显像。在SPM5平台下,设置不同置信水平(p)与三维像素水平(k),对癫痫病灶部位代谢减低区个数与脑部所有减低区个数的百分比进行统计学分析。结果 PET示病灶多位于颞叶;病灶侧及其对侧与小脑的T/NT值分别为1.07±0.24和1.27±0.18,两者具有统计学差异(t=1.87,P<0.05)。SPM5软件处理,病灶主要集中于颞叶19区、21区和39区及顶叶和枕叶7区、19区、31区、40区和47区;选取不同k值,所得半定量结果分别为(27±22)%、(29±24)%、(32±23)%、(35±27)%及(39±31)%,组间无差异(F=0.59,P>0.05);选取不同p值,半定量结果分别为(42±30)%、(29±25)%及(26±21)%,组间存在差异(F=3.60,P<0.05);置信水平p与上述半定量结果之间存在直线回归关系(回归系数6-18.24,t=2.57,P<0.05)。结论 SPM5软件分析PET原始图像时,置信水平p对软件分析结果有影响,p取值越小,软件分析所得结果越优。SPM5能更加客观准确定位病灶。
Abstract:
Objective To investigate the value of statistical parametric mapping 5 (SPM5) and its parameter settings in analysis of PET imaging for epilepsy patients. Methods Seventeen epilepsy patients and seventeen controls were scanned with PET. The datas were analyzed using PET and SPM5 with qualitative and semiquantitative analysis, statistical analysis of the percentage (numbers of agent distribution decreasing in focus to brain) for different parameters combinations, which were value adjustment to contral-p and voxels-k. Results There was decreasing of agent distribution at temporal lobe in epilepsy patients detecting with PET; the T/NT of focus to cerebellum was 1.07±0.24, the T/NT of normal tissue in opposite side to cerebellum was 1.27±0.18, there was a significant difference (t=1.87, P<0.05). Dealing with SPM5, there was more significant decreasing of agent in regions 19, 21, 39 of temporal lobe, regions 7, 19, 31, 40, 47 of parietal lobe and occipital lobe in epilepsy patients. With different value of k, the percentage was (27 ±22)%, (29±24)%, (32±23)%, (35±27)%, (39 ±31)% respectively, there was not significant difference (F=0.59, P>0.05); for different value of p, the percentage was (42±30)%, (29±25)%, (26±21)% respectively, with a significant difference (F=3.60, P<0.05); there was linear regression in value adjustment to contral-p and the percentage(b=-18.24, t=2.57, P<0.05). Conclusions Semiquantitative analysis by SPM5, the setting of value adjustment to contral-p would affect the results, the smaller of value adjustment to contral-p, the better of the result. SPM5 would be more objective and accurate to locate the focuses.

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备注/Memo

备注/Memo:
收稿日期:2008-08-10。
通讯作者:晋建华(E-mail:jjhl225@126.com)
更新日期/Last Update: 1900-01-01