[1]侯敏.癫痫的PET受体显像[J].国际放射医学核医学杂志,2003,27(4):168-171.
　HOU Min.Receptor imaging by PET in epilepsy[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(4):168-171.
点击复制

癫痫的PET受体显像(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第4期
页码:
168-171
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Receptor imaging by PET in epilepsy
作者:
侯敏
200040 上海, 复旦大学上海医学院华山医院核医学科
Author(s):
HOU Min
Departvnent of Nuclear Medicine, Huashan Hospital Medical Center of Fudan University, Shanghai 200040, China
关键词:
癫痫; 正电子发射体层显像; 受体
Keywords:
epilepsy; receptor; positron emission tomography
分类号:
R817.4
摘要:
癫痫患者脑组织标本及癫痫动物模型研究发现,多种神经递质与癫痫有关。通过向体内引入这些神经递质不同受体亚型的特异性放射性配体,可以得到脑内受体分布图,反映它们在癫痫发生中的作用,同时检测出癫痫灶,这也就是癫痫的PET受体显像原理。较之于传统的癫痫检查方法,PET受体显像的特异性和敏感性都极高,可以检测出MRI、CT阴性的癫痫灶,具有很高的临床诊断价值,而且为研究癫痫的发病机制、抗痫药物及抗痫疗效评估提供了一种很好的无创伤性手段,从而为难治性癫痫的最终攻克带来希望。
Abstract:
Alterations in a variety of neurotransmitter systems have been identified in experimental models of epilepsy and in brain tissue from patients with intractable temporal lobe seizures.The availability of new high-affinity radioligands per-mits the study of some neuroreceptors in vivo with positron emission tomography (PET).Receptor imaging by PET offers distinctive advantages over the more established imaging methods,including improved chemical specificity and improved sensitivity in detecting changes in disease.Development of new PET methods for the study of presynaptic and postsynaptic neurotransmitter functions will offer unique opportunities in the study of epileptic mechanisms and the way to assess the ef-fect of antiepilepstics,which will bring light on complete overcome of epilepsy.

参考文献/References:

[1] Juhasz C, Chugani DC, Muzik O, et al. Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy[J]. Neurology, 2000, 55(6): 825-835.
[2] Hammers A, Koepp MJ, Hurlemann R, et al. Abnormalities of grey and white matter[11C] flumazenil binding in temporal lobe epilepsy with normal MRI[J]. Brain, 2002, 125(10): 2257-2271.
[3] Juhasz C, Muzik O, Chugani DC, et al. Prolonged vigabatrin treatment modifies developmental changes of GABA(A)-receptor binding in young children with epilepsy[J]. Epilepsia,2001, 42(10): 1320-1326.
[4] 邱炳辉.PET显像与癫痫灶定位[J].国外医学·神经病学神经外科学分册,2000,27(6): 323-327.
[5] Duncan JS. Positron emission tomography receptor studies[J]. Adv Neurol, 1999, 79: 893-899.
[6] Kumlien E, Hartvig P, Valind S,et al. NMDA-receptor activity visualized with (S)-[N-methyl-11C] ketamine and positron emission tomography in patients with medial temporal lobe epilepsy[J]. Epilepsia, 1999, 40(1): 30-37.
[7] Pennell PB. PET: cholinergic neuroreceptor mapping[J].Adv Neurol, 2000, 83: 157-163.
[8] Dupont S, Semah F, Lo?h C, et al. In vivo imaging of muscarinic cholinergic receptors in temporal lobe epilepsy with a new PET tracer: [76Br] 4-bromodexetimide[J]. J Nucl Med, 1999, 40(6): 935-941.
[9] Bonati MT, Combi R, Asseha R, et al. Exclusion of linkage of nine neuronal nicotinic acetylcholine receptor subunit genes expressed in brain in autosomal dominant nocturnal frontal lobe epilepsy in four unrelated families[J]. J Neurol,2002, 249(8): 967-974.
[10] Kumlien E, Nilason A, Hagberg G, et al. PET with 11C-deuterium-deprenyl and 18F-FDG in focal epilepsy[J]. Acta Neural Stand, 2001, 103(6): 360-366.
[11] Fedi M, Reutens D, Okazawa H,et al. Localizing value of alpha-methyl-L-tryptophan PET in intractable epilepsy of neocortical origin[J]. Neurology, 2001, 57(9): 1629-1636.
[12] Chugani DC, Chugani HT, Muzik O, et al. Imaging epilepto-genic tubers in children with tuberous sclerosis complex using alpha-[11C]methyl-L-tryptophan positron emission tomography[J]. Ann Neurol, 1998,44(6): 858-866.

相似文献/References:

[1]王晓慧,陈雪红,柳江燕,等.发作期SPECT脑血流灌注显像和VEEG在癫痫灶定位诊断中的一致性[J].国际放射医学核医学杂志,2014,38(6):368.[doi:10.3760/cma.j.issn.1673-4114.2014.06.005]
　Wang Xiao-hui,Chen Xue-hong,Liu Jiang-yan,et al.The consistency of ictal SPECT and VEEG studies in localizing the epileptic focus[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):368.[doi:10.3760/cma.j.issn.1673-4114.2014.06.005]
[2]宁艳丽,晋建华,张宏,等.SPM5软件分析癫痫患者脑PET图像的应用研究[J].国际放射医学核医学杂志,2009,33(1):26.[doi:10.3760/cma.j.issn.1673-4114.2009.01.026]
　NING Yan-li,dIN Jian-hua,ZHANG Hong,et al.Application study of SPM5 in analysis of PET imaging for epilepsy patient[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):26.[doi:10.3760/cma.j.issn.1673-4114.2009.01.026]
[3]宁艳丽,晋建华.癫痫脑内相关受体改变及其PET研究[J].国际放射医学核医学杂志,2009,33(2):65.[doi:10.3760/cma.j.issn.1673-4114.2009.02.001]
　NING Yan-li,JIN Jian-hua.Study progress on related receptor changes and PET of epilepsy[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):65.[doi:10.3760/cma.j.issn.1673-4114.2009.02.001]
[4]白侠,王雪梅.PET脑显像对致痫灶的定位方法[J].国际放射医学核医学杂志,2009,33(6):337.[doi:10.3760/cma.j.issn.1673-4114.2009.06.005]
　BAI Xia,WANG Xue-mei.The methods of PET cerebral imaging in focus localizing of epilepsy[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):337.[doi:10.3760/cma.j.issn.1673-4114.2009.06.005]
[5]王晓慧,陈雪红,柳江燕.功能影像学在癫痫灶定位诊断中的应用[J].国际放射医学核医学杂志,2009,33(4):229.[doi:10.3760/cma.j.issn.1673-4114.2009.04.011]
　WANG Xiao-hui,CHEN Xue-hong,LIU Jiang-yan.The application of functional brain imaging in diagnosis of epilepsy localization[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):229.[doi:10.3760/cma.j.issn.1673-4114.2009.04.011]
[6]左传涛.脑中风患者脑功能重塑研究中应注意的问题[J].国际放射医学核医学杂志,2005,29(1):1.
　ZUO Chuan-tao.The issues in the study of brain plasticity after stroke[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):1.
[7]蔡莉,李彦生.氟代脱氧葡萄糖与氨基酸PET在脑肿瘤中的对比研究[J].国际放射医学核医学杂志,2005,29(1):10.
　CAI Li,LI Yan-sheng.Comparison of 18F-FDG and amino acid PET imaging in brain tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):10.
[8]季仲友.PET-CT中诊断性CT的必要性与临床应用[J].国际放射医学核医学杂志,2005,29(5):197.
　JI Zhong-you.Necessity and clinical application of diagnostic CT in PET-CT scanner[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):197.
[9]陈香,赵军,管一晖.PET-CT常见伪影[J].国际放射医学核医学杂志,2005,29(5):201.
　CHEN Xiang,ZHAO Jun,GUAN Yi-hui.Common artifacts on PET-CT images[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):201.
[10]吴湖炳.18F-氟代脱氧葡萄糖PET-CT在头颈部肿瘤中的应用价值[J].国际放射医学核医学杂志,2005,29(5):205.
　WU Hu-bing.The clinical application value of 18F-FDG PET-CT on the head and neck cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):205.
[11]董爱生,田建明.部分癫痫的神经影像学诊断[J].国际放射医学核医学杂志,2005,29(4):148.
　DONG Ai-sheng,TIAN Jian-ming.Neuroimaging in the diagnosis of partial epilepsy[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):148.
[12]祖德贵.MRI与PET对癫痫病的诊断价值[J].国际放射医学核医学杂志,2004,28(2):60.
　ZU De-gui.The value of MRI and PET in the diagnosis of epilepsy[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(4):60.

备注/Memo

备注/Memo:
收稿日期:2002-12-10
作者简介:侯敏(1978-),女,硕士研究生,主要从事神经核医学诊断研究。
更新日期/Last Update: 1900-01-01