[1]董爱生,田建明.部分癫痫的神经影像学诊断[J].国际放射医学核医学杂志,2005,29(4):148-151.
　DONG Ai-sheng,TIAN Jian-ming.Neuroimaging in the diagnosis of partial epilepsy[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):148-151.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第4期
页码:
148-151
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Neuroimaging in the diagnosis of partial epilepsy
作者:
董爱生;  田建明
200433 上海, 上海第二军医大学长海医院核医学科
Author(s):
DONG Ai-sheng;  TIAN Jian-ming
Department of Nuclear Medicine, Ruijin Hospital, Shanghai Second Medical University 200025, China
关键词:
癫痫; 正电子发射体层显像; 磁共振波谱分析; 单光子发射体层显像
Keywords:
partial epilepsy; positron emission tomography; magnetic resonance spectroscopy; single photon emission computed tomography
分类号:
R817.4
摘要:
功能影像研究在部分癫痫综合征的评价中非常重要。磁共振波谱分析(MRS)有助于发现脑代谢物和一些神经递质,当没发现脑结构异常时,各种代谢物水平的下降具有判断预后的参考价值。PET可以显示葡萄糖代谢下降的区域,这些区域是致癫灶的标志,且通常大于结构异常区。PET对颞叶癫痫的定侧有用,然而对源于颞叶外的癫痫灶没有大的帮助,对此具有前景的是苯二氮()类受体配体显像,因为此配体显像的稀疏区的分布更局限,这将对来源于颞叶外的致癫灶的定位更有帮助。临近癫痫发作前后的SPECT可以显示脑血流的增加,且对于MRI正常的患者的癫痫发作的定侧和定位很有帮助。
Abstract:
Functional neuroimaging studies are essential in the evaluation of individuals with partial epilepsy syndromes. Magnetic resonance spectroscopy(MRS) allows us to investigate cerebral metabolites and some Reduction in various metabolite concentrations has proven to be prognostieally valuable no structure abnormality is identified. PET using deoxyglueose demonstrates areas of reduced glucose metabolism, which are the hallmark of epileptogenie zones and usually extend beyond the underlying anatomical region. It is useful in temporal lobe epilepsy for lateralization, however, results extratemporal lobe epilepsy have been less favorable. More promising is the use of benzodiazepine receptor ligands, which are reduced in the epileptogenie zone in a more restricted distribution. This appears to be helpful in the localization of extratemporal seizure foci. Peri-ietal SPECT measures increases blood flow during the ietal event and is beneficial in patients with normal MRI studies to determine lateralization and localization of ietal onset zone.

参考文献/References:

1 Engel JJr. Overview of functional neuroimaging in epilepsy[J]. Adv Neurol, 2000, 83:1-9.
2 Constantinidis I. MRS methodology[J]. Adv Neurol, 2000, 83:235-246.
3 Maton BM, Kuzniecky RI. Proton MRS:N-acetylaspatate, cteatine,and choline[J]. Adv Neuro, 2000, 83:253-259.
4 Spencer SS, Bautista RE. Functional neuroimaging in localization of the ictal onset zone[J]. Adv Neurol, 2000, 83:285-296.
5 Cendes F, Caramanos Z, Andermann F, et al. Proton magnetic resonance spectroscopic imaging and magnetic resonance imaging volumetry in the lateralization of temporal lobe epilepsy:a series of 100patients[J]. Ann Neurol, 1997, 42(5):737-746.
6 Cendes F, Andermann F, Dubeau F, et al. Normalization of neuronal metabolic dysfunction after surgery for temporal lobe epilepsy. Evidence from proton MR spectroscopic imaging[J]. Neurology, 1997,49(6):1525-1533.
7 Laxer KD. Phosphorus MRS:pH, ATP, PCr[J]. Adv Neurol, 2000,83:273-277.
8 Theodore WH. PET:cerebral blood flow and glucose metabolismpathophysiology and drug effects[J]. Adv Neuro, 2000, 83:121-130.
9 O’Brien TJ, Newton MR, Cook MJ, et al. Hippocampal atrophy is not a major determinant of regional hypometabolism in temporal lobe epilepsy[J]. Epilepsia, 1997, 38:74-80.
10 Theodore WH, Gaillard WD. Positron emission tomography in neocortical epilepsies[J]. Adv Neuro, 2000, 84:435-446.
11 Alexander H, Matthias J, Koepp, et al. Grey and white matter flumazenil biding in neocortical epilepsy with normal MRI. A PET study of 44 patients[J]. Brain, 2003, 126(pt6):1300-1318.
12 Anny S, Paul D, Violina L, et al. Increased expression of "peripheral-type" benzodiazepine receptors in human temporal lobe epilepsy:implications for PET imaging of hippocampal sclerosis[J]. Metab Brain Dis, 2002, 17(1):3-11.
13 Hammers A, Koepp MJ, Richardsons MP, et al. Central benzodiazepine receptors in malformations of cortical development:a quantitative study[J]. Brain, 2001, 124(pt8):1555-1565.
14 Richardson MP, Keopp MJ, Brooks DJ, et al. 11C-flumazenil PET in neocortical epilepsy[J]. Neurology, 1998, 51(2):485-492.
15 Muzik O, da Silva EA, Juhasz C, et al. Intracranial EEG versus flumazenil and glucose PET in children with extrateporal lobe epilepsy[J]. Neurology, 2000, 54(1):171-179.
16 Lewis PJ, Siegel A, Siegel AM, et al. Does performing image registration and subtraction in ictal brain SPECT help localize neocortical seizures?[J]. J Nucl Med, 2000, 41(10):1619-1626.
17 Stefan H, Hopp P, Platsch G, et al. SPECT:ictal perfusion in localization-related epilepsies[J]. Adv Neurol, 2000, 83:41-50.
18 Lancman ME, Morris HH Ⅲ, Raja S, et al. Usefulness of ictal and interical 99mTc ethyl cysteinate dimer single photon emission computed tomography in patients with refractory partial epilepsy[J]. Epilepsia,1997, 38(4):466-471.
19 O’Brien TJ, So EL, Mullan BP, et al. Subtraction ictal SPECT coregistered to MRI improves clinical usefulness of SPECT in localizing the surgical seizure focus[J]. Neurology, 1998, 50(2):445-454.
20 Cascino GD. Advances in neuroimaging:surgical localization[J].Epilepsia, 2001, 42(1):3-12.
21 So EL. Integration of EEG, MRI, and SPECT in localizing the seizure focus for epilepsy surgery[J]. Epilepsia, 2000, 41(Suppl 3):S48-S54.
22 Viviane B, Paola V, Edouard H, et al. Correlation between PET and SISCOM in temporal lobe epilepsy[J]. J Nucl Med, 2002, 43(8):991-998.

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备注/Memo

备注/Memo:
收稿日期:2004-11-24。
更新日期/Last Update: 1900-01-01