[1]李玉,董丹,阎英.肿瘤辐射增敏机制研究进展[J].国际放射医学核医学杂志,2007,31(1):48-50.
 LI Yu,DONG Dan,Yah Ying.The development of radiosensitizer mechanisms[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):48-50.
点击复制

肿瘤辐射增敏机制研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第1期
页码:
48-50
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The development of radiosensitizer mechanisms
作者:
李玉1 董丹2 阎英1
1. 110015 沈阳, 沈阳军区总医院放射治疗科;
2. 116027 大连, 大连医科大学临床系
Author(s):
LI Yu1 DONG Dan2 Yah Ying1
1. Department of Radiotherapy, General Hospital of Shenyang Military Command, Shenyang 110015, China;
2. Department of Clinical, Dalian Medical University, Dalian 116027, China
关键词:
肿瘤辐射增敏药放射疗法
Keywords:
NeoplasmsRadiosensitizing agentsRadiotherapy
分类号:
R811.5
摘要:
辐射增敏作用机制非常复杂,迄今为止尚无明确的解释。其机制主要包括改变肿瘤微环境、清除自由基和电子、细胞周期同步化、抑制DNA损伤修复、促进细胞凋亡和生物还原作用。辐射增敏作用机制的研究在提高肿瘤放疗效果方面具有重要的理论指导意义。
Abstract:
Mechanism of radiosensitivity is very complex, there has been no definite explanation up to now. According to literatures, changing tumor microenvironment, clear free radical and electron, making cell cycle synchronization, suppressing repairment of DNA injury, promoting apoptosis and biological reduction are the main mechanisms. Studying mechanisms of radiosensitivity will help to improve the effect of radiotherapy.

参考文献/References:

1 Vaupel P, Kellehe DK, Thews O. Modulation of tumor oxygenatio.Int J Radiat Oncol Biol Phys,1998,42(4):843-848.
2 Lee CG, Heijn M, di Tomaso E. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res, 2000, 60(19):5565-5570.
3 Ansiaux R, Baudelet C, Jordan BF. Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment. Clin Cancer Res, 2005, 11(2 Pt 1):743-750.
4 张红梅,王唯红.乙丙昔罗对肿瘤放射治疗的增敏作用及机制.中国新药与临床杂志,2004,23(11):799-803.
5 Nguyen LN, Munshi A, Hobbs ML, et al. Paclitaxel restores radiation-induced apoptosis in a bcl-2-expressing, radiation resistant lymphoma cell line. Int J Radiat Oncol Biol Phys, 2001,49(4):1127-1132.
6 耿长新,曾昭冲,王吉耀.多西他赛对人肝癌放疗增敏及其作用机制探讨.复旦学报(医学版),2003,30(3):255-258.
7 袁健,孙宁.细胞周期与鼻咽癌的放射增敏.海南医学院学报,2004,10(3):139-142.
8 Kuhne M, Riballo E, Rief N, et al. Double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity.Cancer Res, 2004, 64(2):500-508.
9 Allal AS, Kahne T, Reverdin AK, et al. Radioresistance-related proteins in rectal cancer. Proteomics, 2004, 4(8):2261-2269.
10 Kim CH, Park SJ, Lee SH. A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation. J Pharmacol Exp Ther, 2002, 303(2):753-759.
11 Dikomey E, Duen D. Effect of heat on DSB repair in G1- and Sphase studied in the human HeLa S3 cell line. Int J Radiat Biol,2000, 76(10):1335-1341.
12 Seno JD, Dynlacht JR. Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock. J Cell Physiol, 2004, 199(2):157-170.
13 Nikiforova MN, Stringer JR, Blough R, et al. Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. Science, 2000, 290(5489):138-141.
14 Gradzka I, Buraczewska I, Kuduk-Jaworska J, et al. Radiosensitizing properties of novel hydroxydicarboxylatoplatinum (Ⅱ) complexes with high or low reactivity with thiols:two modes of action. Chem Biol Interact, 2003, 146(2):165-177.
15 Wachters FM, van Putten JW, Maring JG, et al. Selective targeting of homologous DNA recombination repair by gemcitabine. Int J Radiat Oncol Biol Phys, 2003, 57(2):553-562.
16 Dittmann K, Mayer C, Rodemann HP. Inhibition of radiation-induced EGFR nuclear import by C225(Cetuximab) suppresses DNA-PK activity. Radiother Oncol, 2005, 76(2):157-161.
17 Tavema P, Hwang HS, Schupp JE, et al. Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitizer. Cancer Res, 2003, 63(4):838-846.
18 肖绍文,张珊文,吕有勇,等.外源性p53基因对人胃癌细胞的放射增敏作用.北京大学学报(医学版),2001,33(5):427-431.
19 崔滨滨,刘明,赵鹏,等.重组腺病毒介导的野生型p53基因对结直肠癌细胞的放射治疗增敏作用.中华外科杂志,2005,43(15):1002-1005.
20 Gallo O, Boddi V, Calzolari A, et al. Bcl-2 protein expression correlates with recurrence and survival in early stage head and neck cancer treated by radiotherapy. Clin Cancer Res, 1996, 2(2):261-267.
21 Kelly JD, Williamson KE, Weir HP, et al. Induction of apoptosis by mitomycin-C in an exvivo model of bladder cancer. BJU Int,2000, 85(7):911-917.
22 Rischin D, Peters L, Hicks R, et al. Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer. J Clin Oncol, 2001, 19(2):535-542.

相似文献/References:

[1]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
 He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[2]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
 Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[3]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[4]陈晓艳,张江虹,邵春林.STAT3与辐射敏感相关性的研究进展[J].国际放射医学核医学杂志,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
 Chen Xiaoyan,Jianghong,Shao Chunlin.Research progresses of correlation between STAT3 and radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
[5]赵舒怡,储小飞,樊赛军.血清肿瘤标志物与肿瘤放疗疗效评估的研究进展[J].国际放射医学核医学杂志,2015,39(5):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
 zhao shuyi,chu xiaofei,fan saijun..progression of study on serum tumor markers in evaluation of tumor radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
[6]霍小东,王慧星,阎卫亮,等.血管内皮抑制素对125I近距离照射裸鼠肺癌移植瘤的增敏效应研究[J].国际放射医学核医学杂志,2016,40(5):357.[doi:10.3760/cma.j.issn.1673-4114.2016.05.006]
 Huo Xiaodong,Wang Huixing,Yan Weiliang,et al.Sensitization effect of endostatin for 125I brachytherapy on transplanted tumor in nude mice[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):357.[doi:10.3760/cma.j.issn.1673-4114.2016.05.006]
[7]赵徵鑫,翟贺争,张文艺,等.质子重离子治疗肿瘤的进展[J].国际放射医学核医学杂志,2016,40(5):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
 Zhao Zhixin,Zhai Hezheng,Zhang Wenyi,et al.Development of proton heavy ion in tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
[8]任佳忠,李永梅,刘岩,等.99Tcm-MDP骨显像胸部异常放射性摄取的原因分析[J].国际放射医学核医学杂志,2016,40(6):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
 Jiazhong,Li Yongmei,Liu Yan,et al.Reasons for the abnormal 99Tcm-MDP uptake in the thoracic tissue on bone scintigraphy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
[9]马彦云,张辉.磁共振体素内不相干运动扩散加权成像的原理及应用进展[J].国际放射医学核医学杂志,2016,40(6):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
 Ma Yanyun,Zhang Hui.The basic principle and application progress of intravoxel incoherent motion imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
[10]杨卫东,汪静.肿瘤核素靶向治疗新进展[J].国际放射医学核医学杂志,2015,39(1):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
 Yang Weidong,Wang Jing.Advance progress of radionuclide target tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]

备注/Memo

备注/Memo:
收稿日期:2006-07-24。
通讯作者:董丹,E-mail:dongdan1026@163.com
更新日期/Last Update: 1900-01-01