[1]徐宇平,杨敏,曹国宪.σ受体及其在肿瘤核医学中的应用[J].国际放射医学核医学杂志,2006,30(3):136-138.
 XU Yu-ping,YANG Min,CAO Guo-xian.Sigma receptor and the application in tumor nuclear medicine[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):136-138.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第3期
页码:
136-138
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Sigma receptor and the application in tumor nuclear medicine
作者:
徐宇平 杨敏 曹国宪
214063 无锡, 江苏省原子医学研究所卫生部核医学重点实验室
Author(s):
XU Yu-ping YANG Min CAO Guo-xian
Department of Research, The Key Laboratory of Nuclear Medicine of Ministry of Public Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
关键词:
肿瘤σ受体核医学
Keywords:
TumorSigma receptorNuclear medicine
分类号:
R817.4
摘要:
σ受体是一类非阿片受体,其在各种肿瘤如恶性黑色素瘤、神经胶质瘤、乳腺癌、前列腺癌和肺癌等中高度表达,而在正常组织中的表达高度保守。通过对其分类、功能、分布、配体及其在肿瘤核医学中的应用研究,将有助于肿瘤的早期诊断和针对肿瘤细胞的靶向治疗。
Abstract:
The sigma receptor is a class of non-opiate receptor. It is overexpressed in a wide variety of human tumor such as malignant melanoma, neural, breast, prostate and lung cancer, while being highly restricted in most normal tissues. The studies of sigma receptor in the isoforms, functionsv, distribution, ligand and application in tumor nuclear medicine will be helpful in the early diagnosis and treatment of tumors.

参考文献/References:

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9 Caveliers V, Everaert H, John CS, et al. Sigma receptor scintigraphy with N-[2-(1’-piperidinyl)ethyl]-3-^123iodo-4-methoxybenzamide of patients with suspected primary breast cancer:first clinical results.J Nucl Med, 2002, 43(12):1647-1649.
10 Choi SR, Yang B, Plossl K, et al. Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent. Nucl Med Biol, 2001, 28(6):657-666.
11 Mach RH, Huang Y, Buchheimer N, et al.[18F] N-4’-fluorbenzyl-4-(3-bromophenyl) acetamide for imaging the sigma receptor status of tumors:comparison with[18F]FDG and[125I]IUDR. Nucl Med Biol, 2001, 28(4):451-458.
12 John CS, Vilner B J, Geyer BC, et al. Targeting sigma receptor-binding benzamides as in vivo diagnostic and therapeutic agents for human prostate tumors. Cancer Res, 1999, 59(18):4578-4583.
13 Moody TW, Leyton J, John C. Sigma ligand inhibit the growth of small cell lung cancer cells. Life Sci, 2000, 66(20):1979-1986.
14 Mach RH, Huang Y, Freeman RA, et al. Conformationally-flexible benzamide analogues as dopamine D3 and Sigma2 receptor ligands.Bioorg Med Chem Lett, 2004, 14(1):195-202.

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备注/Memo

备注/Memo:
收稿日期:2005-10-24。
基金项目:卫生部核医学重点实验室青年基金资助项目(QN200504)
通讯作者:杨敏(E-mail:ymztk@163.com)
更新日期/Last Update: 1900-01-01