[1]金民山,张俊,姜一逸,等.18F-FDG PET/CT在不明原发灶肿瘤中的临床应用价值[J].国际放射医学核医学杂志,2017,41(2):94-97,149.[doi:10.3760/cma.j.issn.1673-4114.2017.02.003]
　Jin Minshan,Zhang Jun,Jiang Yiyi,et al.Clinical value of 18F-FDG PET/CT in cancer of unknown primary[J].International Journal of Radiation Medicine and Nuclear Medicine,2017,41(2):94-97,149.[doi:10.3760/cma.j.issn.1673-4114.2017.02.003]
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18F-FDG PET/CT在不明原发灶肿瘤中的临床应用价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
41
期数:
2017年第2期
页码:
94-97,149
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Clinical value of 18F-FDG PET/CT in cancer of unknown primary
作者:
金民山;  张俊;  姜一逸;  戴春雷;  梁劲峰
225300 江苏, 江苏省泰州市人民医院核医学科
Author(s):
Jin Minshan;  Zhang Jun;  Jiang Yiyi;  Dai Chunlei;  Liang Jinfeng
Department of Nuclear Medicine, Taizhou People’s Hospital, Taizhou 225300, China
关键词:
氟脱氧葡萄糖F18; 正电子发射断层显像术; 体层摄影术; X线计算机; 不明原发灶肿瘤
Keywords:
Fluorodeoxyglucose F18; Positron-emission tomography; Tomography;  X-ray computed; Cancer of unknown primary
DOI:
10.3760/cma.j.issn.1673-4114.2017.02.003
摘要:
目的 探讨18F-FDG PET/CT全身显像在不明原发灶肿瘤（CUP）诊断中的临床应用价值。方法 回顾分析46例于2015年2月至2016年6月在我院行常规检查未能发现肿瘤原发灶而进一步行18F-FDG PET/CT全身显像查找肿瘤原发灶的转移性肿瘤患者的资料。PET/CT图像分析采用视觉及半定量分析方法。通过病理活检和（或）临床综合诊断、临床随访对结果进行评价。结果 46例患者中，18F-FDG PET/CT显像找到原发肿瘤33例，均经过病理活检及临床随访证实；13例未发现原发病灶。18F-FDG PET/CT对不明肿瘤原发灶的检出率为71.7%（33/46），其中阳性患者中淋巴瘤3例、胃癌2例、食管癌4例、卵巢癌3例、肺癌14例、肝癌2例、尿路上皮癌1例、鼻咽癌2例、多发性骨髓瘤1例、降结肠癌1例。转移方式主要有淋巴结转移32例、骨转移20例、肝转移13例、肺转移9例、胸膜腹膜转移5例、肾上腺转移3例、脑转移4例、皮下转移3例、心包膜转移1例。结论 18F-FDG PET/CT全身显像对CUP的检出率显著优于一般常规检查，对临床指导治疗有着重要意义。
Abstract:
Objective To evaluate the clinical value of 18F-FDG PET/CT whole-body imaging in the manage-ment of cancer of unknown primary(CUP). Methods From February 2015 to June 2016, 46 CUP patients were analyzed retrospectively in Taizhou People’s Hospital. They underwent 18F-FDG PET/CT imaging to detect their primary tumors that had not been detected through routine examinations. Visual and semiquantitative analyses were then employed to analyze the PET/CT images. The results were assessed on the basis of the pathological results, comprehensive clinical diagnoses, and clinical follow-ups. Results Of the 46 patients, 33 had primary tumors, which were detected through 18F-FDG PET/CT imaging and further confirmed by pathology or clinical follow-up. Meanwhile, the primary tumors in 13 patients were not characterized. The CUP detection rate of the 18F-FDG PET/CT was 71.7%(33/46). Of the 33 patients with detected CUPs, 3 had lymphoma, 2 had gastric cancer, 4 had esophageal cancer, 3 had oophoroma, 14 had lung cancer, 2 had liver cancer, 1 had urinary tract epithelial cancer, 2 had nasopharyngeal carcinoma, 1 had multiple myeloma, and 1 had colon cancer. The modes of tumor metastasis included lymphatic metastasis in 32 cases, bone metastasis in 20 cases, liver metastasis in 13 cases, lung metastasis in 9 cases, pleural and peritoneal metastasis in 5 cases, adrenal metastasis in 3 cases, brain metastasis in 4 cases, subcutaneous metastasis in 3 cases, and pericardium metastasis in 1 case. Conclusions The 18F-FDG PET/CT outperforms ordinary routine examinations in terms of CUP detection. Thus, 18F-FDG PET/CT possesses significant importance to clinical management.

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备注/Memo

备注/Memo:
收稿日期:2016-11-01。
通讯作者:张俊,Email:dr.junzhang@hotmail.com
更新日期/Last Update: 2017-04-24