[1]阿米娜·依布拉音,张奇洲,李肖红,等.18F-FDG和18F-FLT PET/CT不同诊断方法在肺部单发结节中的临床价值分析[J].国际放射医学核医学杂志,2015,39(4):295-299.[doi:10.3760/cma.j.issn.1673-4114.2015.04.005]
　Amina·Yibulayin,Zhang Qizhou,Li Xiaohong,et al.Differential diagnosis protocols of 18F-FDG and 18F-FLT PET/CT for solitary pulmonary nodules[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):295-299.[doi:10.3760/cma.j.issn.1673-4114.2015.04.005]
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18F-FDG和18F-FLT PET/CT不同诊断方法在肺部单发结节中的临床价值分析(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第4期
页码:
295-299
栏目:
出版日期:
2015-07-25

文章信息/Info

Title:
Differential diagnosis protocols of 18F-FDG and 18F-FLT PET/CT for solitary pulmonary nodules
作者:
阿米娜·依布拉音;  张奇洲;  李肖红;  李毓斌;  吕洁;  谢彬;  刘立水;  秦永德
新疆医科大学第一附属医院核医学科, 乌鲁木齐, 830011
Author(s):
Amina·Yibulayin;  Zhang Qizhou;  Li Xiaohong;  Li Yubin;  Lyu Jie;  Xie Bin;  Liu Lishui;  Qin Yongde
Department of Nuclear Medicine, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China
关键词:
单发肺结节; 氟脱氧葡萄糖F18; 胸腺嘧啶核苷; 正电子发射断层显像术; 体层摄影术; X线计算机
Keywords:
Solitary Pulmonary Nodules; Fluorodeoxyglucose F18; Fluorothymidine; Positron-emission tomography; Tomography;  X-ray computed
DOI:
10.3760/cma.j.issn.1673-4114.2015.04.005
摘要:
目的 探讨18F-FDG和18F-胸腺嘧啶核苷(FLT) PET/CT不同的诊断方法对肺部单发结节的诊断价值。方法 对40例发现肺部单发结节的患者行18F-FDG和18F-FLT PET/CT显像,所有病例均经病理或密切随访确诊,应用受试者工作特征(ROC)曲线比较18F-FDG SUVmax、18F-FLT SUVmax、18F-FLT SUVmax/同层面椎体SUVmax对肺部恶性肿瘤的诊断价值;18F-FDG和18F-FLT PET/CT两种显像结果均行视觉分析和半定量分析,比较不同诊断方法的诊断效能。结果 18F-FDG SUVmax、18F-FLT SUVmax及18F-FLT SUVmax/同层面椎体SUVmaxROC曲线下面积分别为0.687、0.821和0.817。以18F-FDG SUVmax>2.5、18F-FLT SUVmax>2.0为恶性诊断标准、18F-FDG PET/CT视觉分析评分法、18F-FLT PET/CT视觉分析评分法4种方法诊断肺癌的灵敏度、特异度和准确率分别为88.2%、73.9%和80.0%;58.8%、82.6%和72.5%;94.1%、91.3%和92.5%;88.2%、65.2%和75.0%。结论 18F-FLT SUVmax及18F-FLT SUVmax/同层面椎体SUVmax单独诊断肺部恶性肿瘤的价值较18F-FDG SUVmax高,且前两者可替换使用。18F-FDG PET/CT视觉评分法在肺部单发结节良恶性的诊断中效能最佳。
Abstract:
Objective To investigate the diagnostic values of 18F-FDG and 3’-deoxy-3’-18F-fluorothymidine (18F-FLT) PET/CT for solitary pulmonary nodules.Methods 18F-FDG and 18F-FLT PET/CT imaging were performed in 40 patients with solitary pulmonary nodules.All cases were confirmed by pathology or follow-up.The diagnostic values of 18F-FDG SUVmax,18F-FLT SUVmax,and 18F-FLT/the same level of vertebral SUVmax for pulmonary malignant tumor were compared using the receiver operating characteristic (ROC) curves.18F-FDG and 18F-FLT imaging results were analyzed by visual observation and semi-quantitative analysis.The diagnostic efficiencies of the different diagnostic methods were compared.Results Areas under the ROC curves of 18F-FDG SUVmax,18F-FLT SUVmax,and 18F-FLT/same level of vertebral SUVmax were 0.687,0.821,and 0.817,respectively.The diagnostic sensitivities,specificities,and accuracies of tested diagnostic tools were as follows:18F-FDG SUVmax >2.5 as the malignant diagnostic criteria,88.2%,73.9% and 80.0%;18F-FLT SUVmax>2.0 as the malignant diagnostic criteria,58.8%,82.6% and 72.5%;18F-FDG PET/CT visual analysis of scoring method,94.1%,91.3% and 92.5%;and 18F-FLT PET/CT for visual analysis of scoring method 88.2%,65.2% and 75.0%.Conclusions 18F-FLT SUVmax and 18F-FLT/vertebral SUVmax showed higher accuracies in diagnosing solitary pulmonary modules compared with 18F-FDG SUVmax.18F-FDG PET/CT visual scoring method was the most effective in diagnosing solitary pulmonary nodules.

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备注/Memo

备注/Memo:
收稿日期:2014-09-10。
通讯作者:秦永德,Email:qyd199013@163.com
更新日期/Last Update: 1900-01-01