[1]郑玉明.敷贴治疗寻常型银屑病的疗效分析[J].国际放射医学核医学杂志,2015,39(4):300-302.[doi:10.3760/cma.j.issn.1673-4114.2015.04.006]
　Zheng Yuming.Clinical effectiveness of applicator brachytherapy for psoriasis vulgaris[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):300-302.[doi:10.3760/cma.j.issn.1673-4114.2015.04.006]
点击复制

敷贴治疗寻常型银屑病的疗效分析(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第4期
页码:
300-302
栏目:
出版日期:
2015-07-25

文章信息/Info

Title:
Clinical effectiveness of applicator brachytherapy for psoriasis vulgaris
作者:
郑玉明
山东省东平县人民医院核医学科, 泰安, 271500
Author(s):
Zheng Yuming
Department of Nuclear Medicine, DongPing County People’s Hospital, Taian 271500, China
关键词:
银屑病; 放射性核素; 90Sr-90Y敷贴器; 敷贴治疗
Keywords:
Psoriasis; Radionuclides; 90Sr/90Y applicator; Brachytherapy
DOI:
10.3760/cma.j.issn.1673-4114.2015.04.006
摘要:
目的 探讨90Sr-90Y敷贴与口服复方氨肽素片治疗寻常型局限性银屑病的疗效及安全性。方法 将108例寻常型局限性银屑病患者按治疗意愿分为敷贴治疗组和药物治疗组。敷贴治疗组:按常规敷贴治疗,每个疗程治疗5次,隔日1次,每疗程总吸收剂量为30~50 Gy;药物治疗组:口服复方氨肽素片,1次口服5片,每日3次,连续治疗9周为1个疗程。结果 90Sr-90Y敷贴治疗组痊愈患者为32例,显效为19例,总有效率为87.93%;复方氨肽素治疗组痊愈患者为16例,显效为14例,总有效率为60.00%。χ2检验得出两组总有效率的差异有统计学意义(χ2=11.17,P<0.05)。不良反应比较,两组不良反应发生率分别为17.24%和32.00%,差异无统计学意义(χ2=3.20,P>0.05)。复发情况比较,两组复发率分别为21.88%和56.25%,差异有统计学意义(χ2=5.67,P<0.05)。结论 90Sr-90Y敷贴治疗方法简单、无痛苦、疗效高、复发率低,患者不用长期服药,可以作为一种治疗寻常型局限性银屑病的有效方法。
Abstract:
Objective To evaluate the efficacy of 90Sr/90Y applicator brachytherapy as a treatment for psoriasis vulgaris.Methods A total of 108 patients with psoriasis vulgaris received either the 90Sr/90Y applicator brachytherapy or the amino-polypeptide drug therapy.The brachytherapy group was treated every other day;each course consisted of five sessions for a total dose of 30 Gy to 50 Gy.The drug therapy group was treated with 15 tablets of amino-polypeptide per day for 9 weeks.Results The success rate of the treatment for psoriasis vulgaris was significantly higher (χ2=11.17,P<0.05) in the brachytherapy group (87.93%) than in the drug therapy group (60.00%).The rates of adverse reaction in the two groups were 17.24% and 32.00%,respectively,although this disparity was not significantly different (χ2=3.20,P>0.05).The relapse rate was significantly lower (χ2=5.67,P<0.05) in the brachytherapy group (21.88%) than in the drug therapy group (56.25%).Conclusions The 90Sr/90Y applicator brachytherapy is both simple and painless,with a high success rate and low relapse rate;thus,brachytherapy is one of the most effective treatment for psoriasis vulgaris.

参考文献/References:

[1] 赵辨. 中国临床皮肤病学[M]. 南京:江苏科学技术出版社, 2009:1008.
[2] Capon F, Dallapiccola B, Novelli G. Advances in the search for psoriasis susceptibility genes[J]. Mol Genet Metab, 2000, 71(1/2):250-255.
[3] 杨雪琴. 银屑病与心身医学[J]. 人民军医, 2004, 47(8):481-484.
[4] 张奇亮. 敷贴治疗核医学[M]. 济南:济南出版社, 2004:53.
[5] 鲁智勇, 姚志荣, 戴红, 等. 国产卡泊三醇软膏治疗寻常性银屑病多中心临床研究[J]. 中华皮肤科杂志, 2010, 43(9):645-646.
[6] 黄岚, 马莉, 黄琼, 等. 钙泊三醇倍他米松软膏外用治疗寻常性银屑病的随机、双盲、对照研究[J]. 中华皮肤科杂志, 2009, 42(10):691-694.
[7] 罗绍淼, 范敏, 苏禧, 等. NB-UVB联合中药浴治疗寻常性银屑病的临床观察[J]. 中华皮肤科杂志, 2010, 43(4):284-285.
[8] Nast A, Kopp I, Augustin M, et al. German evidence-based guidelines for the treatment of Psoriasis vulgaris(short version)[J]. Arch Dermatol Res, 2007, 299(3):111-138.
[9] Katugampola RP, Hongbo Y, Finlay AY. Clinical management decisions are related to the impact of psoriasis on patient-rated quality of life[J]. Br J Dermatol, 2005, 152(6):1256-1262.
[10] 黄钢. 核医学与分子影像临床操作规范[M]. 2版. 北京:人民卫生出版社, 2014:316.
[11] 陈菊华, 黄春艳. 复方氨肽素对进展期寻常型银屑病的疗效观察[J]. 现代医药卫生, 2006, 22(4):496-497.

相似文献/References:

[1]万建美,范我.动脉粥样硬化斑块核素显像研究进展[J].国际放射医学核医学杂志,2007,31(1):17.
　WAN Jian-mei,FAN Wo.The progress of research on atherosclerotic plaque nuclear imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(4):17.
[2]陈立波,朱瑞森.NIS在肿瘤核素基因显像与治疗中的应用研究[J].国际放射医学核医学杂志,2005,29(2):70.
　CHEN Li-bo,ZHU Rui-sen.Progress of application study on sodium/iodide symporter as a radionuclide imaging and therapeutic gene[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):70.
[3]刘彧.放射性核素在关节炎治疗中的应用[J].国际放射医学核医学杂志,2003,27(2):59.
　LIU Yu.The application of radionuclide therapy in arthritis[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(4):59.
[4]陈建伟.放射性核素近距离治疗血管再狭窄的现状和进展[J].国际放射医学核医学杂志,2002,26(3):97.
　CHEN Jian-wei.The status quo and progress of radionuclides for intravascular brachytherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(4):97.
[5]欧晓红.放射性核素反义治疗[J].国际放射医学核医学杂志,2002,26(6):246.
　OU Xiao-hong.Radionuclide antisense therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(4):246.
[6]王任飞,谭建.血管腔内近距离照射预防介入治疗后再狭窄的研究现状[J].国际放射医学核医学杂志,2001,25(4):153.
　WANG Ren-fei,TAN Jian.Current study of intravascular brachytherapy preventing restenosis after interventional therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(4):153.
[7]秦光明.肿瘤核素反义显像技术的研究现状与展望[J].国际放射医学核医学杂志,2001,25(5):213.
　QIN Guang-ming.Current researches and prospective of radiolabeled antisense imaging in tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(4):213.
[8]赵晋华,林祥通.抑郁症的放射性核素脑血流灌注和脑受体显像研究进展[J].国际放射医学核医学杂志,1998,22(2):49.
[9]诸洪达,陆梅,朱昌寿.食入放射性核素所致内照射剂量研究现状及展望[J].国际放射医学核医学杂志,1998,22(3):130.
[10]杨卫东,朱承谟.肿瘤反义显像技术中的若干问题[J].国际放射医学核医学杂志,1998,22(6):244.

备注/Memo

备注/Memo:
收稿日期:2014-12-11。
通讯作者:郑玉明,Email:zymzb001@sina.com
更新日期/Last Update: 1900-01-01