[1]欧晓红.放射性核素反义治疗[J].国际放射医学核医学杂志,2002,26(6):246-248.
　OU Xiao-hong.Radionuclide antisense therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(6):246-248.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第6期
页码:
246-248
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Radionuclide antisense therapy
作者:
欧晓红
610041 成都, 四川大学华西医院核医学科
Author(s):
OU Xiao-hong
Department of Nuclear Medicine, West China Hospital of Si Chuan University, Chengdu 610041, China
关键词:
放射性核素; 反义治疗; 寡核苷酸
Keywords:
radionuclide; antisense therapy; oligonucleotide
分类号:
R817.5;Q74
摘要:
放射性核素反义治疗将反义寡核苷酸阻断癌基因表达作用及放射性核素杀伤癌细胞作用结合在一起,是一项新兴的治疗技术。这项研究目前仍处于初步阶段,只有少量放射性寡核苷酸细胞毒性、动物体内药代动力学及组织学分布的报道。简要综述了目标基因的选择和反义寡核苷酸的标记、导入细胞及其毒副作用等几个放射性核素反义治疗有关的重要环节及其最新进展。
Abstract:
Radionuclide antisense therapy achieves the joint goals of antisense therapy and internal radioation therapy.There have been a small number of investigations on the radionuclide antisense therapy in tissue culture and in animal studies.Considerable research is required before this novel technique can become a working practice.We reviewed some question and development on the radionuclide antisense therapy,such as selection of the target gene sequence,labelling the antisense oligonucleotide,improvement of the uptake and target of radionuclide antisense oligonucleotides and evaluation of the toxicity of the radionuclide antisense therapy.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2001-11-20。
作者简介:欧晓红(1974-),女,四川广安人,博士研究生,主要从事放射性反义治疗研究。
更新日期/Last Update: 1900-01-01