[1]谢彦婷,郑容.18F-FDG PET/CT在食管癌放疗中的应用[J].国际放射医学核医学杂志,2013,37(1):42-46.[doi:10.3760/cma.j.issn.1673-4114.2013.01.012]
 XIE Yan-ting,ZHENG Rong.The application of 18F-FDG PET/CT in the radiotherapy of esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):42-46.[doi:10.3760/cma.j.issn.1673-4114.2013.01.012]
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18F-FDG PET/CT在食管癌放疗中的应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第1期
页码:
42-46
栏目:
综述
出版日期:
2013-01-25

文章信息/Info

Title:
The application of 18F-FDG PET/CT in the radiotherapy of esophageal cancer
作者:
谢彦婷 郑容
北京协和医学院中国医学科学院肿瘤医院核医学科及PET/CT中心, 北京, 100021
Author(s):
XIE Yan-ting ZHENG Rong
Department of Nuclear Medicine and PET/CT Center, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
关键词:
食管肿瘤放射疗法肿瘤分期氟脱氧葡萄糖F18正电子发射断层显像术体层摄影术X线计算机
Keywords:
Esophageal neoplasmsRadiotherapyNeoplasm stagingFluorodeoxyglucose F18Positron-emission tomographyTomographyX-ray computed
DOI:
10.3760/cma.j.issn.1673-4114.2013.01.012
摘要:
随着三维适形和调强放疗技术的发展,放射治疗成为食管癌的重要治疗手段之一。准确的肿瘤分期和精确的靶区勾画是食管癌精确放疗成功的先决条件。常规影像在指导食管癌精确放疗计划、早期疗效监测以及检测肿瘤复发中有很大帮助,但仍存在许多局限性。PET/CT作为一种功能与解剖的融合影像,可以弥补传统影像的某些不足,在食管癌的诊治中发挥着越来越重要的作用。该文将主要对18F-FDG PET/CT在食管癌放疗前分期、放疗靶区勾画、疗效监测及预后评估等方面的应用进行探讨。
Abstract:
With the development of three dimensional conformal radiotherapy and intensity modulated radiotherapy,radiotherapy becomes an important treatment for esophageal cancer.Accurate staging and target volume delineation are prerequisites for a successful treatment of esophageal cancer with radiotherapy.Conventional cross-sectional images are helpful for guiding radiotherapy plans,assessing treatment response and detecting recurrence.But there are still many limitations for anatomic information alone.PET/CT is an imaging fusion modality which may overcome some limitations of conventional crosssectional modalities.It plays an important role in the diagnosis and treatment of esophageal cancer.This review evaluates the applications of 18F-FDG PET/CT in the initial staging before radiotherapy,its target volume definition,treatment response and the prognosis of esophageal cancer.

参考文献/References:

[1] Kato H,Miyazaki T,Nakajima M,et al.The incremental effect of positron emission tomography on diagnostic accuracy in the initial staging of esophageal carcinoma.Cancer,2005,103(1):148-156.
[2] Tanabe S,Naomoto Y,Shirakawa Y,et al.F-18 FDG PET/CT con-tributes to more accurate detection of lymph nodal metastasis from actively proliferating esophageal squamous cell carcinoma.Clin Nucl Med,2011,36(10):854-859.
[3] Hsu WH,Hsu PK,Wang SJ,et al.Positron emission tomography-computed tomography in predicting locoregional invasion in esophageal squamous cell carcinoma.Ann Thorac Surg,2009,87(5):1564-1568.
[4] Schröder W,Baldus SE,Mönig SP,et al.Lymph node staging of esophageal squamous cell carcinoma in patients with and without neoadjuvant radiochemotherapy:histomorphologic analysis.World J Surg,2002,26(5):584-587.
[5] van Vliet EP,Heijenbrok-Kal M H,Hunink MG,et al.Staging investigations for oesophageal cancer:a meta-analysis.Br J Can-cer,2008,98(3):547-557.
[6] van Westreenen HL,Westerterp M,Bossuyt PM,et al.Systematic review of the staging performance of 18F-fluorodeoxyglucose positron emission tomography in esophageal cancer.J Clin Oncol,2004,22(18):3805-3812.
[7] Yuan S,Yu Y,Chao KS,et al.Additional value of PET/CT over PET in assessment of locoregional lymph nodes in thorac icesophageal squamous cell cancer.J Nucl Med,2006,47(8):1255-1259.
[8] Schreurs LM,Pultrum BB,Koopmans KP,et al.Better assessment of nodal metastases by PET/CT fusion compared to side-by-side PET/CT in oesophageal cancer.Anticancer Res,2008,28(3B):1867-1873.
[9] Kato H,Kimura H,Nakajima M,et al.The additional value of inte-grated PET/CT over PET in initial lymph node staging of esophageal cancer.Oncol Rep,2008,20(4):857-862.
[10] Flamen P,Lerut A,Van Cutsem E,et al.Utility of positron emissionto mography for the staging of patients with potentially operable esophageal carcinoma.J Clin Oncol,2000,18(18):3202-3210.
[11] Gillies RS,Middleton M R,Maynard ND,et al.Additional benefit of 18F-fluorodeoxyglucose integrated positron emission tomography/computed tomography in the staging of oesophageal cancer.Eur Radiol,2011,21(2):274-280.
[12] Okada M,Murakami T,Kumano S,et al.Integrated FDG-PET/CT compared with intravenous contrast-enhanced CT for evaluation of metastatic regional lymph nodes in patients with resectable early stage esophageal cancer.Ann Nucl Med,2009,23(1):73-80.
[13] Moureau-Zabotto L,Touboul E,Lerouge D,et al.Impact of CT and 18F-deoxyglucose positron emission tomography image fusion for conformal radiotherapy in esophageal carcinoma.Int J Radiat Oncol BiolPhys,2005,63(2):340-345.
[14] 郭洪波,于金明,张百江,等.氟脱氧葡萄糖PET-CT确定食管癌淋巴结放疗靶区的可行性研究.中华放射肿瘤学杂志,2007,16(1):10-14.
[15] Gondi V,Bradley K,Mehta M,et al.Impact of hybrid fluo-rodeoxyglucose positron-emission tomography/computed tomogra-phy on radiotherapy planning in esophageal and non-small-cell lung cancer.Int J Radiat Oncol Biol Phys,2007,67(1):187-195.
[16] Hong TS,Killoran JH,Mamede M,et al.Impact of manual and automated interpretation of fused PET/CT data on esophageal target definitions in radiation planning.Int J Radiat Oncol Biol Phys,2008,72(5):1612-1618.
[17] Muijs CT,Schreurs LM,Busz DM,et al.Consequences of addition-al use of PET information for target volume delineation and radio-therapy dose distribution for esophageal cancer.Radiother Oncol,2009,93(3):447-453.
[18] Schreurs LM,Busz DM,Paardekooper GM,et al.Impact of 18-fluo-rodeoxyglucose positron emission tomography on computed tomog-raphy defined target volumes in radiation treatment planning of esophageal cancer:reduction in geographic misses with equal inter-observer variability:PET/CT improves esophageal target definition.Dis Esophagus,2010,23(6):493-501.
[19] Zhong X,Yu J,Zhang B,et al.Using 18F-fluorodeoxyglucose positron emission tomography to estimate the length of gross tumor in patients with squamous cell carcinoma of the esophagus.Int J Radiat Oncol Biol Phys,2009,73(1):136-141.
[20] Yu W,Fu XL,Zhang YJ,et al.GTV spatial conformity between dif-ferent delineation methods by 18-FDG PET/CT and pathology in esophageal cancer.Radiother Oncol,2009,93(3):441-446.
[21] Han D,Yu J,Yu Y,et al.Comparison of 18F-fluorothymidine and 18F-fluorodeoxyglucose PET/CT in delineating gross tumor volume by optimal threshold in patients with squamous cell carcinoma of thoracic esophagus.Int J Radiat Oncol Biol Phys,2010,76(4):1235-1241.
[22] Jeganathan R,McGuigan J,Campbell F,et al.Does pre-operative estimation of oesophageal tumour metabolic length using 18F-fluo-rodeoxyglucose PET/CT images compare with surgical pathology length?.Eur J Nucl Med Mol Imaging,2011,38(4):656-662.
[23] Westerterp M,Omloo JM,Sloof GW,et al.Monitoring of response to pre-operative chemoradiation in combination with hyperthermia in oesophageal cancer by FDG-PET.Int J Hyperthermia,2006,22(2):149-160.
[24] Bruzzi JF,Swisher SG,Truong MT,et al.Detection of interval dis-tant metastases:clinical utility of integrated CT-PET imaging inpatients with esophageal carcinoma after neoadjuvant therapy.Cancer,2007,109(1):125-134.
[25] Roedl JB,Haiisinghani MG,Colen RR,et al.Assessment of treat-ment response and recurrence in esophageal carcinoma based on tumor length and standardized uptake value on positron emission tomography-computed tomography.Ann Thorac Surg,2008,86(4):1131-1138.
[26] Klaeser B,Nitzsche E,Schuller JC,et al.Limited predictive value of FDG-PET for response assessment in the preoperative treatment of esophageal cancer:results of a prospective multi-center trial(SAKK 75/02).Onkologie,2009,32(12):724-730.
[27] Monjazeb AM,Riedlinger G,Aklilu M,et al.Outcomes of patients with esophageal cancer staged with[18F] fluorodeoxyglucose positron emission tomography (FDG-PET):can postchemoradiotherapy FDG-PET predict the utility of resection?.J Clin Oncol,2010,28(31):4714-4721.
[28] Brown C,Howes B,Jamieson GG,et al.Accuracy of PET/CT in pre-dicting survival in patients with esophageal cancer.World J Surg,2012,36(5):1089-1095.
[29] 朱婉琦,于金明,孙晓蓉,等.FDG PET/CT代谢体积对食管癌术后预后的预测价值.中华核医学杂志,2011,31(6):378-381.
[30] Guo H,Zhu H,Xi Y,et al.Diagnostic and prognostic value of 18F-FDG PET/CT for patients with suspected recurrence from squamous cell carcinoma of the esophagus.J Nucl Med,2007,48(8):1251-1258.

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备注/Memo

备注/Memo:
收稿日期:2012-08-30。
基金项目:北京希望马拉松专项基金(项目编号:LC2011A09)
通讯作者:郑容,Email:zhengrong_2004@yahoo.com.cn
更新日期/Last Update: 1900-01-01