[1]邢志伟,姜恩海,王桂林,等.《造血刺激因子在急性放射病治疗中的应用规范》解读[J].国际放射医学核医学杂志,2012,36(4):234-237.[doi:10.3760/cma.j.issn.1673-4114.2012.04.010]
 XING Zhi-wei,JIANG En-hai,WANG Gui-lin,et al.Explanation of Application Standards of Hematopoietic Stimulating Factors in the Treatment of Acute Radiation Sickness[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(4):234-237.[doi:10.3760/cma.j.issn.1673-4114.2012.04.010]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第4期
页码:
234-237
栏目:
标准解读
出版日期:
1900-01-01

文章信息/Info

Title:
Explanation of Application Standards of Hematopoietic Stimulating Factors in the Treatment of Acute Radiation Sickness
作者:
邢志伟1 姜恩海1 王桂林2 罗庆良3
1. 中国医学科学院放射医学研究所, 天津市分子核医学重点实验室, 天津 300020;
2. 军事医学科学院附属307医院, 北京 100039;
3. 军事医学科学院放射医学研究所, 北京 100057
Author(s):
XING Zhi-wei1 JIANG En-hai1 WANG Gui-lin2 LUO Qing-liang3
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China
关键词:
辐射损伤造血细胞生长因子职业卫生标准
Keywords:
Radiation injuriesHematopoietic cell growth factorsOccupational health criteria
DOI:
10.3760/cma.j.issn.1673-4114.2012.04.010
摘要:
《造血刺激因子在急性放射病治疗中的应用规范》作为卫生部行业标准,已完成了报批稿,该标准广泛调研了造血刺激因子治疗急性放射病相关动物的实验文献及近十余年来造血刺激因子应用于国内外辐射事故的临床报告,并参考了国际原子能机构、美国国家战略储备辐射工作组及欧洲多国关于造血刺激因子应用的建议。该标准主要用于核事故应急和放射事故导致的骨髓型急性放射病的治疗,其他导致造血衰竭的疾病也可参照应用,为更好地执行这一标准,该文对标准的相关内容进行解读。
Abstract:
Occupational standard of the Ministry of health——Application Standards of Hematopoietic Stimulating Factors in the Treatment of Acute Radiation Sickness has been completed as a draft standard. Based on the wide study and analysis of related animal experimental literature about hematopoietic stimulating factor in the treatment of acute radiation sickness and domestic and foreign clinical reports about application of hematopoietic stimulating factor in radiation accidents in the past decade, the standard was enacted according to the suggestions of International Atomic Energy Agency and the United States Strategic National Stockpile Radiation Working Group and European countries about the application of hematopoieticstimulating factor. It is mainly used for nuclear accident emergency and the treatment of the bone marrow form of acute radiation sickness caused by radiation accidents. It also applies to other hematopoietic failure diseases. In order to implement this standard correctly, the relevant contents of the standard were interpreted in this article.

参考文献/References:

[1] 蒋本荣,艾辉胜,叶根耀,等.外照射急性放射病临床诊治中面临的一个重要课题.中华放射医学与防护杂志,2007,27(1):43-46.
[2] Butturini A, De Souza PC, Gale RP, et al. Use of recombinant gran-ulocyte-macrophage colony simulating in the Brazil radiation accident. Lancet, 1988, 2(8609):471-475.
[3] 罗庆良,从玉史,郝静,等.造血因子与急性放射病.解放军医学杂志,2005,30(3):186-190.
[4] 楼滨城,丁秀兰,张耀臣,等.忻州60Co源放射事故主要8例受照者临床报告.中华放射医学与防护杂志,1998,18(4):225-229.
[5] 陈虎,王桂林,罗庆良,等.rhG-CSF在一例急性放射病治疗中的应用.中华放射医学与防护杂志,1997,17(1):51-53.
[6] 李美颖,张瑶珍,张东华,等.武汉"921113"放射事故四例急性放射病人的临床报告.中华放射医学与防护杂志,1998,18(4):230-234.
[7] Dainiak N. Hematologic consequences of exposure to ionizing radiation. Exp Hematol, 2002, 30(6):513-528.
[8] Waselenko JK, MacVittie TJ, Blakely WF, et al. Medical management of the acute radiation syndrome:recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med, 2004, 140(12):1037-1051.
[9] Gourmelon P, Benderitter M, Bertho JM, et al. European consensus on the medical management of acute radiation syndrome and analysis of the radiation accidents in Belgium and Senegal. Health Phys, 2010, 98(6):825-832.
[10] 小泽敬也.骨髓移植后造血刺激因子的应用.何娟,译.日本医学介绍,1992,13(2):53-54.
[11] Baranov AE, Selidovkin GD, Butturini A, et al. Hematopoietic recovery after 10-Gy acute total body radiation. Blood, 1994, 83(2):596-599.
[12] International Atomic Energy Agency. The radiological accident in Soreq. Vienna:IAEA, 1993:35-37.
[13] Isaacs C, Robert NJ, Bailey FA, et al, Randomized placebo-controlled study of recombinant human interleukin-ll to prevent chemotherapy-induced thromboeytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxom-bicin. J Clin Oneol, 1997, 15(11):3368-3377.
[14] 王欣茹,郝静,罗庆良.IL-11对造血的刺激作用及其在辐射损伤治疗中的应用.国外医学放射医学核医学分册,2003,27(1):42-44.
[15] 郝静,罗庆良,熊国林,等.rhIL-11加rhG-CSF对8.0Gy照射猴的治疗作用.解放军医学杂志,2001,26(10):730-732.
[16] 胡志清,张学光,王修珍,等.细胞因子治疗60Coγ射线照射所致急性放射病的实验研究.苏州大学学报:医学版,2009,29(3):419-421.
[17] 赵建治,李明,邢爽.等.rhG-CSF和rhIL-11联合治疗极重度骨髓型急性放射病比格狗疗效观察.苏州大学学报:医学版,2010,30(1):23-26.
[18] 邢爽,黄海潇,熊国林,等.重组人粒细胞集落刺激因子和重组人白介素11对3.5Gy照射狗的治疗作用.军事医学科学院院刊,2007,31(4):394-396.
[19] Berger ME, Christensen DM, Lowry PC, et al. Medical management of radiation injuries:current approaches. Occup Med (Lond), 2006, 56(3):162-172.

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备注/Memo

备注/Memo:
收稿日期:2012-06-02。
基金项目:卫生部行业基金(201002009);卫生部标准研究课题(2009-09-07)
通讯作者:姜恩海(Email:jnh1953@yahoo.com.cn
更新日期/Last Update: 1900-01-01