[1]郭永铁,耿洁.双峰型胰岛素释放曲线的初步分析[J].国际放射医学核医学杂志,2010,34(6):359-362.[doi:10.3760/cma.j.issn.1673-4114,2010.06.011]
　GUO Yong-tie,GENG Jie.Preliminary analysis of bimodal insulin release curve[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(6):359-362.[doi:10.3760/cma.j.issn.1673-4114,2010.06.011]
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双峰型胰岛素释放曲线的初步分析(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第6期
页码:
359-362
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Preliminary analysis of bimodal insulin release curve
作者:
郭永铁;  耿洁
天津中医药大学第一附属医院检验科, 300193
Author(s):
GUO Yong-tie;  GENG Jie
Department of Clinical Laboratory, the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
关键词:
糖尿病; 2型; 糖耐量受损; 双峰型胰岛素释放曲线
Keywords:
Diabetes mellitus; type 2; Impaired glucose toleration; Irregularity insulin release curve
DOI:
10.3760/cma.j.issn.1673-4114,2010.06.011
摘要:
目的 初步探讨双峰型胰岛素释放曲线(IRC)出现的原因。方法 以63例双峰型IRC2型糖尿病患者为双峰组、18名正常志愿者为对照组,进行口服葡萄糖耐量试验、胰岛素释放试验和C-肽释放试验,并计算稳态模型指标。结果 两组受试者的空腹血糖、空腹胰岛素、1 h胰岛素、空腹C-肽、1 h C-肽、Homa-1R差异无统计学意义;0.5 h血糖、1 h血糖、2 h血糖、3 h血糖、0.5 h胰岛素、2 h胰岛素、3 h胰岛素、0.5 hC-肽、2 h C-肽、3 hC-肽、血糖曲线下面积、胰岛素曲线下面积、C-肽曲线下面积、胰岛素分泌指数、△I30/△G30:双峰组>对照组,△C-P30/△G30:双峰组<对照组。结论 双峰组患者胰岛第一分泌相过度代偿,0.5 h胰岛素形成假性峰值而导致血糖增高,胰岛第二分泌相形成正常峰值,此组患者应为糖耐量受损。
Abstract:
Objective To investigate the reason for the appearance of bimodal insulin release curve (IRC).Methods Sixty-three cases of bimodal pattern of IRC (double hump group) were selected as experimental group; 18 normal volunteers as control group. Oral glucose tolerance test, insulin release test and C-peptide release test were performed, and the index of steady-state model was calculated.Results There were no significant difference among the two groups in fasting insulin, 1 hC-peptide, fasting plasma glucose, Homa-insulin resistance. 0.5 hIns:double hump group > control group. Fasting C-peptide:control 1 group > double hump group > normal Group. 0.5 h C-peptide:double hump group and control group > normal group. Fasting plasma glucose:normal group > double hump group and control group. 0.5 h plasma gulcose:normal group > double hump group > control group. glucose area under curve:normal group > double hump group > control group; △I30△ G30:double hump group > control group > normal group. insulin area under curve and C-peptide area under curve:double hump group > control group and normal group.There were significant difference among the results.Conclusion s The pancreatic island has an overcompensation in the first secretion phase in double hump group, and the insulin displayed the pseudopeak value at 0.5 h which lead to the increase of blood glucose. The pancreatic island has a normal peak value in the second secretion phase, the patients in this group exsits impaired glucose tolerance.

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备注/Memo

备注/Memo:
收稿日期:2010-08-20。
通讯作者:郭永铁(E-mail:guoyongtie@163.com)
更新日期/Last Update: 1900-01-01