[1]杨美玉,王利利,涂彧.镁离子对放射性脑损伤的脑保护作用[J].国际放射医学核医学杂志,2010,34(6):363-366.[doi:10.3760/cma.j.issn.1673-4114,2010.06.012]
　YANG Mei-yu,WANG Li-li,TU Yu.Brain protection by magnesium ion against radioaction brain injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(6):363-366.[doi:10.3760/cma.j.issn.1673-4114,2010.06.012]
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镁离子对放射性脑损伤的脑保护作用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第6期
页码:
363-366
栏目:
辐射损伤
出版日期:
1900-01-01

文章信息/Info

Title:
Brain protection by magnesium ion against radioaction brain injury
作者:
杨美玉1;  王利利2;  涂彧1
1. 苏州大学医学部放射医学与公共卫生学院, 215123;
2. 苏州大学附属第一医院放疗科, 215123
Author(s):
YANG Mei-yu1;  WANG Li-li2;  TU Yu1
Academy of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou 215123, China
关键词:
脑损伤; 硫酸镁; 辐射防护
Keywords:
Brain injury; Magnesium sulfate; Radiation protection
DOI:
10.3760/cma.j.issn.1673-4114,2010.06.012
摘要:
放射性腩损伤是脑部肿瘤放射治疗的严重并发症之一,近几年对Mg2+的研究证明了其在脑损伤中的保护作用,是目前综合性评价前景较好的神经保护剂。该文综述了放射性脑损伤后脑组织中的Mg2+变化情况及产生原因,并从减轻炎性反应、减轻脑水肿,抑制脂质过氧化、抗细胞凋亡,改善神经功能等方面分析了Mg2+对放射性脑损伤的保护机制。
Abstract:
Radiation brain injury is a serious complication among the radiotherapy of brain tumors.It is demonstrated that the protective action of magnesium ion in the brain injury from some experimental studies recent years, which is the prospective neuroprotective agents overall merits. This article is summarized the causes and the variance of magnesium ion in the brain tissue afterwards the radioactive brain injury,additionally the defense mechanism of magnesium ion from the aspects of inflammation reduction, encephaledema alleviation, anti-apoptosis and improcement of nerve function.

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备注/Memo

备注/Memo:
收稿日期:2010-05-11。
通讯作者:涂彧(E-mail:tuyu@suda.edu.cn)
更新日期/Last Update: 1900-01-01