[1]邹钢,胡晓蓉,李翠吟,等.妊娠糖尿病患者肿瘤坏死因子的动态变化与胰岛素抵抗的关系[J].国际放射医学核医学杂志,2009,33(2):93-96.[doi:10.3760/cma.j.issn.1673-4114.2009.02.009]
　ZOU Gang,HU Xiao-rong,LI Cui-yin,et al.Alteration of serum tumor necrosis factor-alpha level in gestational diabetes mellitus and correlation with insulin resistance[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):93-96.[doi:10.3760/cma.j.issn.1673-4114.2009.02.009]
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妊娠糖尿病患者肿瘤坏死因子的动态变化与胰岛素抵抗的关系(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第2期
页码:
93-96
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Alteration of serum tumor necrosis factor-alpha level in gestational diabetes mellitus and correlation with insulin resistance
作者:
邹钢1;  胡晓蓉2;  李翠吟1;  邵豪1;  陆泽元1;  赖丽萍1;  柳岚1
1. 深圳市第四人民医院内分泌科, 深圳 518033;
2. 深圳市第四人民医院妇产科, 深圳 518033
Author(s):
ZOU Gang1;  HU Xiao-rong2;  LI Cui-yin1;  SHAO Hao1;  LU Ze-yuan1;  LAI Li-ping1;  LIU Lan1
1. Department of Endocrinology, The Fourth People’s Hospital of Shenzhen, Shenzhen 518033, China;
2. Department of Gastroenterology, The Fourth People’s Hospital of Shenzhen, Shenzhen 518033, China
关键词:
糖尿病; 妊娠; 肿瘤坏死因子; 胰岛素抵抗
Keywords:
Diabetes;  gestational; Tumor necrosis factor; Insulin resistance
DOI:
10.3760/cma.j.issn.1673-4114.2009.02.009
摘要:
目的 探讨妊娠糖尿病(GDM)患者肿瘤坏死因子α(TNF-α)的动态变化与胰岛素抵抗(IR)的关系.方法 选择GDM患者32例(GDM组)、正常孕妇31例(NGT组)为研究对象,分别测定孕25~28周、孕29~32周、孕37~38周、产后6~8周空腹血TNF-α、胰岛素、血糖水平,采用放射免疫法测定TNF-α和胰岛素,葡萄糖氧化酶法测定空腹血糖.以稳态模式评估法的胰岛素抵抗指数(HOMA-IR)评价IR.结果 ① GDM组、NGT组血清TNF-α水平均随孕期的增加而升高,且均显著高于产后;② GDM患者妊娠各时期TNF-α水平均显著高于NGT (t值分别为7.81、7.05、7.15,P<0.01);③血清TNF-α水平与HOMA-IR显著正相关(r=0.571,P<0.05).结论 GDM患者血清中TNF-α水平随孕期的增加而升高,且显著高于产后,TNF-α的动态变化与IR相关.
Abstract:
Objective To explore the dynamic of tumor necrosis factor-alpha(TNF-α)and its correlation with insulin resistance(IR)during different stages of gestational diabetes mellitus(GDM).Methods Thirty-two subjects with GDM and 31 cases of normal pregnant women nonnal glucose tolerance,NGT were enrolled in the study,serum TNF-α and insulin were determined by radioimmunoassay.The plasma glucose was measured by using glucose oxidase.Tests repeated for each group according different stages of prenatal 25~28 weeks,29~32 weeks,37~38 weeks and postpartum 6~8 weeks.IR was assessed by the homeostasis model of assessment for insulin resistance index(HOMA-IR).Results ① Serum TNF-α levels in GDM and NGT group rose with gestational age,and both significantly decreased at postpartum. ② Serum TNF-α levels in GDM of above-mentioned four stages respectively were(7.05±0.67)ng/L,(7.11±0.75)ng/L,(7.36±0.79)ng/L,(5.46±0.37)ng/L respectively.All significantly increased than those in the same stage group(t=7.81,7.05,7.15,P<0.01). ③ Maternal serum TNF-α levels were in positive correlation with HOMA-IR in GDM(r=0.571,P<0.05).Conclusions Serum TNF-α levels in GDM rose with gestational age,but significantly decreased at postpartum.The dynamic changes of serum TNF-α contribute to occurrence of insulin resistance.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2008-10-03。
基金项目:深圳市科技计划项目(卫生医疗类)(200803145)
通讯作者:邹钢(E-mail:zhenjin1969@yahoo.com.cn)
更新日期/Last Update: 1900-01-01