[1]汪永红,陈文新,何品玉.肿瘤表皮生长因子受体的分子显像研究[J].国际放射医学核医学杂志,2009,33(4):204-206.[doi:10.3760/cma.j.issn.1673-4114.2009.04.004]
 WANG Yong-hong,CHEN Wen-xin,HE Pin-yu.Tumor epidermal growth factor receptor molecular imaging research[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):204-206.[doi:10.3760/cma.j.issn.1673-4114.2009.04.004]
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肿瘤表皮生长因子受体的分子显像研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第4期
页码:
204-206
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Tumor epidermal growth factor receptor molecular imaging research
作者:
汪永红 陈文新 何品玉
福建医科大学省立临床学院、福建省立医院核医学科, 神州, 350001
Author(s):
WANG Yong-hong CHEN Wen-xin HE Pin-yu
Department of Nuclear Medicine, Fujum Provincial Hospital, Provincial Clinical College, Fujian Medical University, Fuzhou 350001, China
关键词:
受体表皮生长因子肿瘤放射性核素显像
Keywords:
Receptorepidermal growth factorNeoplasmsRadionuclide imaging
DOI:
10.3760/cma.j.issn.1673-4114.2009.04.004
摘要:
表皮生长因子在不同类型肿瘤的生长、发展等不同阶段的信号通路中起着重要的作用,无创性的表皮生长因子受体(EGFR)监测在肿瘤的诊断与疗效的判断中具有重要的意义。近年来针对EGFR的放射性示踪剂研究进展迅速,为ECFR分子显像提供了良好的基础。
Abstract:
Because of the importance of epidermal growth factor signaling pathway in oncogenesis,maintenance, and progression of different types of tumors, there are great significance that non-invasive monitoring of epidermal growth factor receptor (EGFR) in the diagnosis and the judge of therapeutic efficacy.The studys of radioactive tracers for EGFR have provided a good basis for the molecular imaging of EGFR.

参考文献/References:

[1] Walerfield MD.Epidermal growth factor and related molecules.Lancet,1989,333(8649):1243-1246.
[2] Carpenter G,Cohen S.Epidermal growth factor.J Biol Chem,1990,265(14):7709-7712.
[3] 李云春, 谭天秩.表皮生长因子(EGF)与肿瘤的放射性核素显像诊断和治疗.同位素,1999,12(4):222-225.
[4] Rosenthal EL,Kulbersh BD,King T,et al.Use of fluorescent labeled anti-epidermal growth factor receptor antibody to image head and neck squamous cell carcinoma xenografts.Mol Cancer Ther,2007, 6(4):1230-1238.
[5] 彭志平,文明,王树斌, 等.胶质瘤表皮牛长因子受体显像的实验研究.重庆医科大学学报,2007,32(5):467-469.
[6] 熊建萍, 项晓军.抗肿瘤新型靶向药物西妥昔单抗.药品评价,2006,3(6):446-449.
[7] 王洪武.肿瘤分子靶向治疗在实体肿瘤中的应用.中华医学信息导报,2006, 21(9):7-9.
[8] Wang H,Yu JM,Yang GR, et al.Further characterization of the epidermal growth factor receptor ligand 11C-PD 153035.Chin Med J (Engl),2007, 120(11):960-964.
[9] Geiovani JG.Molecular imaging of epidermal growth factor receptor expression-activity at the kinase level in tumors with positron emission tomography.Cancer Metastasis Rev,2008,27(4):645-653.
[10] Nordberg E,Orlova A,Friedman M,et al.In vivo and in vitrouptake of 111In,delivered with the affibody molecule(ZEGFR:955)2, in EGFR expressing tumour cells.Oncol Rep,2008,19(4):853-857.
[11] Gainkam LO,Huang L,Caveliers V,et al.Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice,using pinhole SPECT/micro-CT.J Nucl Med,2008,49(5):788-795.

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备注/Memo

备注/Memo:
收稿日期:2009-04-02。
通讯作者:陈文新,E-mail:wenxinchzt@yahoo.com.cn
更新日期/Last Update: 1900-01-01