[1]陈建波,黄献忠,胡朝晖,等.25-羟维生素D参考区间的建立及其临床意义[J].国际放射医学核医学杂志,2009,33(2):99-101.[doi:10.3760/cma.j.issn.1673-4114.2009.02.011]
　CHEN Jian-bo,HUANG Xian-zhong,HU Chao-hui,et al.Establishment of 25-OH-vitamin D reference interval by radioimmunoassay and its clinical significance[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):99-101.[doi:10.3760/cma.j.issn.1673-4114.2009.02.011]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第2期
页码:
99-101
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Establishment of 25-OH-vitamin D reference interval by radioimmunoassay and its clinical significance
作者:
陈建波;  黄献忠;  胡朝晖;  祖玉丽;  朱庆义
广州金域医学检验中心有限公司, 广州 510330
Author(s):
CHEN Jian-bo;  HUANG Xian-zhong;  HU Chao-hui;  ZU Yu-li;  ZHU Qing-yi
Guangzhou Kingmed Center for Clinical Laboratory Company Limited, Guangzhou 510330, China
关键词:
放射免疫测定; 参考值; 25-羟维生素D
Keywords:
Radioimmunoassay; Reference values; 25-OH-Vit D
DOI:
10.3760/cma.j.issn.1673-4114.2009.02.011
摘要:
目的 建立区域人群25-羟维生素D (25-OH-Vit D)的参考区间,并对用于临床评估提出建议.方法 收集204例健康参考个体的样本,用放射免疫法进行检测,对检测结果进行离群点检查、绘制数据分布图,统计分析25-OH-Vit D的检测结果,对参考区间进行验证和建立.结果 建立的25-OH-Vit D参考区间青少年为16.0~39.7 ng/ml,成年人为11.7~40.0 ng/ml.结论 25-OH-Vit D在人体水平因各个地区人群的年龄、性别、生活习惯等的差异而有所不同.国内区域人群维生素D的摄入量可能整体偏低,故临床医生在评估维生素D状态时,应考虑人体所应有的足够量的25-OH-Vit D.
Abstract:
Objective To establish reference interval of 25-OH-vitamin D(25-OH-Vit D)by radioimmunoassay and provide suggestion for clinical applications.Method Collecting 204 healthy persons specimens,and validating and establishing reference interval of 25-OH-Vit D by treatment of outlying observations,iudgement of data distributions and analysis of teat results.Results The reference interval of 25-OH-Vit D established in our laboratory is 16.0~39.7 ng/ml for adolescents and 11.7~40.0 ng/ml for adults.Conclusions The levels of 25-OH-Vit D in humans depend on their age,sex and life style.Some people’s vitamin D intake is not enough.Doctors should pay attention to the sufficient 25-OH-Vit D needed when evaluate vitamin D intake.

参考文献/References:

[1] Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation, 2008, 117(4):503-511.
[2] Clinical and Laboratory Standards Institute. Defining, establishing, and verifying reference intervals in the clinical laboratory; approved guideline-third edition. CLSI document C28-A3. Wayne, PA:Clinical and Laboratory Standards Institute, 2008.
[3] 崔庆华,张云,薛元明,等.健康儿童,青少年血清生长激素的参考值调查.放射免疫学杂志,2000,13(2):73-74.
[4] Zittermann A. Vitamin D in preventative medicine:are we ignoring the evidence?. Br J Nutr, 2003, 89(5):552-572.

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备注/Memo

备注/Memo:
收稿日期:2009-01-02。
通讯作者:胡朝晖(E-mail:huzh@kingmed.com.cn)
更新日期/Last Update: 1900-01-01