[1]刘义明,叶爱霞,钟娆霞,等.血清β-人绒毛膜促性腺激素、孕酮、雌二醇值对早期正常妊娠、妊娠流产和异位妊娠的诊断价值[J].国际放射医学核医学杂志,2009,33(2):102-104.[doi:10.3760/cma.j.issn.1673-4114.2009.02.012]
　LIU Yi-ming,YE Ai-xia,ZHONG Rao-xia,et al.Diagnostic value of serum β-human chorionic gonadotropin,progesterone and estradiol in early normal pregnancy, pregnancy abortion and ectopic pregnancy[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):102-104.[doi:10.3760/cma.j.issn.1673-4114.2009.02.012]
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血清β-人绒毛膜促性腺激素、孕酮、雌二醇值对早期正常妊娠、妊娠流产和异位妊娠的诊断价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第2期
页码:
102-104
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Diagnostic value of serum β-human chorionic gonadotropin,progesterone and estradiol in early normal pregnancy, pregnancy abortion and ectopic pregnancy
作者:
刘义明1;  叶爱霞1;  钟娆霞1;  莫伟1;  高卉2
1. 广东医学院第二附属医院检验科, 湛江 524003;
2. 广东医学院第二附属医院妇产科, 湛江 524003
Author(s):
LIU Yi-ming1;  YE Ai-xia1;  ZHONG Rao-xia1;  MO Wei1;  GAO Hui2
1. Department of Examine,, Second Affiliated Hospital of Guangdong Medical College, Guangdong Zhanjiang 524003, China;
2. Department of Gynecology, Second Affiliated Hospital of Guangdong Medical College, Guangdong Zhanjiang 524003, China
关键词:
绒毛膜促性腺激素; β亚单位; 人; 孕酮; 雌二醇; 妊娠; 妊娠; 异位; 流产; 自然
Keywords:
Chorionic gonadotropin;  beta subunit;  human; Progesterone; Estradiol; Pregnancy; Pregnancy;  ectopic; Abortion;  spontaneous
DOI:
10.3760/cma.j.issn.1673-4114.2009.02.012
摘要:
目的 动态分析血清β-人绒毛膜促性腺激素(β-HCG)、孕酮和雌二醇值在鉴别早期正常妊娠、宫内妊娠流产和异位妊娠中的价值.方法 将怀孕30~35 d的106例受检者根据妊娠后果分为3组:正常妊娠(先兆流产继续妊娠)组38例,宫内妊娠流产组33例,异位妊娠组35例,采静脉血测定β-HCG、孕酮、雌二醇的水平,48h后用同法复测三项指标.结果 首测时正常妊娠组三项指标均明显高于妊娠流产组和异位妊娠组,而妊娠流产组和异位妊娠组比较,β-HCG、孕酮、雌二醇差异均无统计学意义.复测β-HCG、孕酮、雌二醇,妊娠流产组孕酮值由(14.8±9.6) mg/L下降为(8.7±5.8) mg/L,下降显著,β-HCG、雌二醇差异无统计学意义;以复测β-HCG每48 h升高>60%为阳性、孕酮=20μg/L为阈值及两者联合分析鉴别正常妊娠和异常妊娠(妊娠流产和异位妊娠),有较好的敏感性、特异性和准确率;以复测β-HCG下降>50%为阳性,孕酮=10μg/L为阈值及两者联合分析鉴别妊娠流产和异位妊娠,有较好的敏感性、特异性和准确率,两者联合分析确诊率更高.结论 动态监测血清β-HCG、孕酮、雌二醇的水平及其升高和下降幅度,对鉴别早期正常妊娠、宫内妊娠流产和异位妊娠有一定的诊断价值.
Abstract:
Objective Dynamic assay of serum β-human chorionic gonadotropin(β-HCG),progesterone and estradiol value,in its analysis to identify early normal intrauterine pregnancy,abortion intrauterine pregnancy and ectopic pregnancy in value.Methods One hundred and six subject of pregnant 30~35 d of the patients were divided into three groups:early normal pregnancy group of 38 cases,early intrauterine pregnancy abortion group of 33 cases,ectopic pregnancy group of 35 cases.Determination to adopt blood β-HCG,progesterone,estradiol levels,48 h with the law after the test of the three indicators.Results β-HCG,progesterone,estradiol of normal pregnancy group were significantly higher than the pregnancy abortion group and ectopic pregnancy group.β-HCG,progesterone,estradiol of pregnancy abortion group and ectopic pregnancy group in 30~35 d was no significant difference.Retest of β-HCG,progesterone,estradiol,pregnancy abortion group progesterone decreased from(14.8±9.6)μg/L to(8.7±5.8)μg/L significantly and β-HCG,estradiol was no significant difference.To β-HCG test every 48 h increased >60%positive and progesterone=20μg/L as the threshold between the two and a joint analysis of three methods to identify normal pregnancy and abnormal pregnancy(ectopic pregnancy and pregnancy abortion),there is a better sensitivity and specificity of diagnosis.In order to test β-HCG decline >50% positive and progesterone=10μg/L as the threshold between the two and a joint analysis of three methods to identify progesterone,estradiol pregnancy abortion and ectopic pregnancy,the better sensitivity and specificity of diagnosis,analysis of both the united confirmed a higher rate.Conclusion Dynamicmonitoring of serum β-HCG, progesterone, estradiol have a certain value in early identification of the normal pregnancy, ectopic pregnancy and intrauterine pregnancy abortions.

参考文献/References:

[1] 曹泽毅.中华妇产科学(上下册).第一版.北京:人民卫生出版社,1999:1318.
[2] 许燕丽,武孟香,刘丽萍.血清LIF、TNF-α、E2、P、β-HCG在异位妊娠早期诊断中的作用.中国实用妇科与产科杂志,2008,24(4):298-300.
[3] 阎进,车耀润.孕酮、雌二醇对异位妊娠治疗方案选择的意义.中国妇幼保健,2007,22(9):1234-1235.
[4] 邓亚丽,李晓玲.血清孕酮测定对异位妊娠诊断与监测的价值.中国实用妇科与产科杂志,2005,21(2):106.
[5] 方群.妇产科检验诊断学.北京:人民卫生出版社.2004:97-99.

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备注/Memo

备注/Memo:
收稿日期:2009-01-03。
通讯作者:刘义明(E-mail:liu6433@126.com)
更新日期/Last Update: 1900-01-01