[1]郑青,鲍逸民,杨永青.慢性心力衰竭患者血脂、血浆NT-ProBNP、CTnⅠ和hs-CRP水平测定的临床分析[J].国际放射医学核医学杂志,2014,38(4):232-234,265.[doi:10.3760/cma.j.issn.1673-4114.2014.04.006]
　Zheng Qing,Bao Yimin,Yang Yongqing.The clinical analysis of blood lipid and plasma NT-proBNP, CTnⅠ and hs-CRP levels determined in patients with chronic heart failure[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):232-234,265.[doi:10.3760/cma.j.issn.1673-4114.2014.04.006]
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慢性心力衰竭患者血脂、血浆NT-ProBNP、CTnⅠ和hs-CRP水平测定的临床分析(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第4期
页码:
232-234,265
栏目:
出版日期:
2014-07-25

文章信息/Info

Title:
The clinical analysis of blood lipid and plasma NT-proBNP, CTnⅠ and hs-CRP levels determined in patients with chronic heart failure
作者:
郑青1;  鲍逸民1;  杨永青2
1. 南京医科大学附属苏州市立医院急诊科, 苏州 215002;
2. 南京医科大学附属苏州市立医院核医学科, 苏州 215002
Author(s):
Zheng Qing1;  Bao Yimin1;  Yang Yongqing2
Department of Emergency, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou 215002, China
关键词:
心力衰竭; 充血性; 肌钙蛋白I; C反应蛋白质; 血浆N氨基末端脑钠肽前体; 放射免疫测定; 荧光免疫测定
Keywords:
Heart failure;  congestive; Troponin I; C-reactive protein; Plasma N-terminal pro-brain natriuretic peptide; Radioimmunoassary; Fluoroimmunoassay
DOI:
10.3760/cma.j.issn.1673-4114.2014.04.006
摘要:
目的 测定慢性心力衰竭(CHF)患者的血脂、血浆N氨基末端脑钠肽前体(NT-ProB-NP)、心肌肌钙蛋白Ⅰ(CTnⅠ)和高敏C反应蛋白(hs-CRP)水平并进行临床分析。方法 采用生化法、荧光免疫分析法和放射免疫分析法测定165例CHF患者和60名正常对照者的血脂和血浆NT-ProBNP、CTnⅠ和hs-CRP水平,并进行比较性分析。结果 165例CHF患者血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平较60名正常对照者明显降低(TC:tⅡ=2.214,P<0.05; tⅢ=2.873,P<0.01; tⅣ=3.146; P<0.01; TG:tⅡ=2.167,P<0.05; tⅢ=2.863,P<0.01; tⅣ=3.063,P<0.01; LDL-C:tⅡ=2.147,P<0.05; tⅢ=2.056,P<0.05; tⅣ=2.184,P<0.05; HDL-C:tⅡ=2.137,P<0.05; tⅢ=2.256,P<0.05; tⅣ=3.148,P<0.01).在生物标志物的测定中,165例CHF患者的血浆NT-ProBNP、CTnⅠ和hs-CRP水平与正常对照者之间的差异有统计学意义(NT-proBNP:tⅡ=2.096,P>0.05; tⅢ=2.813,P<0.01; tⅣ=4.135,P<0.001;CTnⅠ:tⅡ=2.736,P<0.01; tⅢ=2.962,P<0.01; tⅣ=3.816,P<0.001; hs-CRP:tⅡ=2.103,P<0.05; tⅢ=2.956,P<0.01;tⅣ=4.452,P<0.001),而且随左心室射血功能(LVEF)的降低而逐步升高。结论 CHF患者血脂水平(TC、TG、LDL-C和HDL-C)随LVEF的降低而降低,具有血脂代谢紊乱的现象;血浆生物标志物水平(NT-ProBNP、CTnⅠ和hs-CRP)随LVEF的降低而升高。
Abstract:
Objective To measure the levels of blood lipid and plasma N-terminal pro-brain natriuretic peptide (NT-proBNP),cardiac troponin Ⅰ (CTnⅠ)and high sensitive C-reaction protein (hsCRP)in patients with chronic heart failure (CHF),and carry out clinical analysis.Methods The blood lipid and plasma NT-proBNP,CTnⅠ and hs-CRP levels in 165 patients with CHF and 60 controls were analyzed by chemistry,fluorescent immunoassay and radioimmunoassay,and then the results were analyzed and compared.Results The serum TC,TG,LDL-C and HDL-C levels in 165 patients with CHF were significantly lower than those of 60 controls (TC:tⅡ=2.214,P<0.05; tⅢ=2.873,P<0.01; tⅣ=3.146; P<0.01;TG:tⅡ=2.167,P<0.05; tⅢ=2.863,P<0.01; tⅣ=3.063,P<0.01; LDL-C:tⅡ=2.147,P<0.05; tⅢ=2.056,P< 0.05; tⅣ=2.184,P<0.05; HDL-C:tⅡ=2.137,P<0.05; tⅢ=2.256,P<0.05; tⅣ=3.148,P<0.01).In biomarkers determining,the plasma NT-proBNP,CTnⅠ and hs-CRP levels in 165 patients with CHF were significantly higher than those of 60 controls (NT-proBNP:tⅡ=2.096,P〉0.05; tⅢ=2.813,P<0.01; tⅣ=4.135,P<0.001;CTnⅠ:tⅡ=2.736,P<0.01; tⅢ=2.962,P<0.01; tⅣ=3.816,P<0.01 and hs-CRP:tⅡ=2.103,P<0.05; tⅢ=2.956,P<0.01; tⅣ=4.452,P<0.001),and the plasma three biomarker levels were increased with decreasing left ventricular ejection function (LVEF).Conclusion The blood lipid (TC,TG,LDL-C and HDL-C)levels were decreased with decreasing LVEF and showing abnormal metabolism,but the plasma biomarkers levels were increased with decreasing LVEF.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2013-09-21。
通讯作者:杨永青(Email:yangyongqing2009@163.com)
更新日期/Last Update: 1900-01-01