[1]孙权,蔡建明,黄越承.富勒烯衍生物对自由基的清除作用及其生物学效应[J].国际放射医学核医学杂志,2008,32(5):308-311.
　SUN Quart,CAI Jian-ming,HUANG Yue-cheng.The ability of fullerene derivatives to eliminate free radicals and their biological effects[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(5):308-311.
点击复制

富勒烯衍生物对自由基的清除作用及其生物学效应(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第5期
页码:
308-311
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The ability of fullerene derivatives to eliminate free radicals and their biological effects
作者:
孙权;  蔡建明;  黄越承
200433 上海, 第二军医大学放射医学研究室
Author(s):
SUN Quart;  CAI Jian-ming;  HUANG Yue-cheng
Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China
关键词:
富勒烯; 自由基; 抗氧化效应
Keywords:
Fullerenes; Free radicals; Antioxidant effect
摘要:
富勒烯及其衍生物因其独特的化学结构和理化性质,尤其是它们强大的清除自由基的能力,引起了生物医学界研究者的极大关注,开展了大量生物学效应研究,近年来取得较大进展。在此重点探讨多种富勒烯衍生物的生物学效应,特别是对自由基清除效应的应用意义及应用前景。
Abstract:
The unique chemical and physical properties of buckminsterfullerene (C60) and its derivatives, especially the excellent ability to eliminate free radicals, have generated increasing interest for researchers in the field of biomedicine.Subsequently, considerable investigations have been conducted into the biological effects of C60, and remarkable progress has been made in recent years.In this paper, we mainly review the biological effects of various C60 derivatives, particularly on the free radical scavenging effect and its significance in practical application.

参考文献/References:

[1] Mirkov SM,Djordjevic AN,Andric NL,et al.Nitric oxide-scavenging activity of polyhydroxylated fullerenol,C60(OH)24[J].Nitric Oxide,2004,11(2):201-207.
[2] Lai HS,Chen WJ,Chiang LY.Free radical scavenging activity of fullerenol on the ischemia-reperfusion intestine in dogs[J].World J Surg,2000,24(4):450-454.
[3] 蔡小青,李宇国,吴胜伟,等.富勒醇对60Coγ射线致小鼠损伤的防护作用[J].中华放射医学与防护杂志,2004,24(6):520-522.
[4] Dugan LL,Iovett EG,Quick KL,et al.Fullerene-based antioxidants and neurodegenerative disorders[J].Parkinsonism Relat Disord,2001,7(3):243-246.
[5] All SS,Hardt JI,Quick KL,et al.A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties[J].Free Radic Biol Med,2004,37(8):1191-1202.
[6] Sun T,Xu Z.Radical scavenging activities of alpha-alanine C60 adduct[J].Bioorg Med Chem Lett,2006,16(14):3731-3734.
[7] Hu Z,Guan W,Wang W,et al.Synthesis of beta-alanine C60 derivative and its protective effect on hydrogen peroxide-induced apoptosis in rat pheochromocytoma cells[J].Cell Biol Int,2007,31(8):798-804.
[8] Hu Z,Liu S,Wei Y,et al.Synthesis of glutathione C60 derivative and its protective effect on hydrogen peroxide-induced apoptosis in rat pheochromocytoma cells[J].Neurosci lett,2007,429(2-3):81-86.
[9] Hsu HC,Chiang yy,Chen WJ,et al.Water-soluble hexasulfobutyl [60] fullerene inhibits plasma lipid peroxidation by direct association with lipoproteins[J].J Cardiovasc Pharmacol,2000,36(4):423-427.
[10] Lee YT,Chiang LY,Chen WJ,et al.Water-soluble hexasulfobutyl [60] fullerene inbibit low-density lipoprotein oxidation in aqueous and lipophilic phases[J].Proc Soc Exp Biol Med,2000,224(2):69-75.
[11] Huang SS,Tsai SK,Chih CL,et al.Neuroprotective effect of hexasulfobutylated C60 on rats subjected to focal cerebral ischemia[J].Free Radic Biol Med,2001,30(6):643-649.
[12] Yang Dy,Wang MF,Chen IL,et al.Systemic administration of a water-soluble hexasulfonated C60(FC4S) reduces cerebral ischemia-induced infarct volume in gerbils[J].Neurosci Lett,2001,311(2):121-124.
[13] Mashino T,Shimotohno K,Ikegami N,et al.Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives[J].Bioorg Med Chem Lett,2005,15(4):1107-1109.
[14] 杨新林,陈哲,孟宪梅,等.三丙二酸富勒烯对DNA限制性内切酶和Taq DNA聚合酶活性的抑制作用[J].科学通报,2007,52(4):399-403.
[15] Tsao N,Luh TY,Chou CK,et al.In vitro action of carboxyfullerene[J].J Antimicrob Chemother,2002,49(4):641-649.
[16] Lee J,Fortner JD,Hughes JB,et al.Photochemical production of reactive oxygen species by C60 in the aqueous phase during UV irradiation[J].Environ Sci Technol,2007,41(7):2529-2535.
[17] 乔新歌,黄成,银亚冰,等.几种不同结构富勒烯衍生物对HeLa细胞的光诱导毒性[J].北京理工大学学报,2007,27(6):556-559.
[18] Usenko CY,Harper SL,Tanguay RL,et al.Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish[J].Toxicol Appl Pharmacol,2008,229(1):44-55.
[19] Fenoglio I,Tomatis M,Lison D,et al.Reactivity of carbon nanotubos:free radical generation or scavenging activity?[J].Free Radic Biol Med,2006,40(7):1227-1233.
[20] Sayes CM,Gobin AM,Ausman KD,et al.Nano-C60 cytotoxicity is due to lipid peroxidation[J].Biomaterials,2005,26(36):7587-7595.
[21] Yang X,Chen L,Qiao X,et al.Photo-induced damages of cytoplasmic and mitochondrial membranes by a[C60] fullerene malonic acid derivative[J].Int J Toxicol,2007,26(3):197-201.
[22] Foley S,Crowley C,Smaihi M,et al.Cellular localisation of a water-soluble fullerene derivative[J].Biochem Biophys Res Commun,2002,294(1):116-119.
[23] Hart B,Karim MN.Cytotoxicity of aggregated fullerene C60 particles on CHO and MDCK cells[J].Scanning,2008,30(2):213-220.

相似文献/References:

[1]屈喜梅,王丽琴,张文艺,等.电子顺磁共振在生物医学研究中的应用[J].国际放射医学核医学杂志,2013,37(2):104.[doi:10.3760/cma.j.issn.1673-4114.2013.02.011]
　QU Xi-mei,WANG Li-qin,ZHANG Wen-yi,et al.The application of electron paramagnetic resonance in biomedical research[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(5):104.[doi:10.3760/cma.j.issn.1673-4114.2013.02.011]
[2]刘忠超,张文艺,焦玲.辐射引起的电子自旋共振信号在回顾剂量学中的应用[J].国际放射医学核医学杂志,2013,37(5):322.[doi:10.3760/cma.j.issn.1673-4114.2013.05.016]
　LIU Zhong-chao,ZHANG Wen-yi,JIAO Ling.The application of radiation-induced free radicals signals in retrospective dosimetry[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(5):322.[doi:10.3760/cma.j.issn.1673-4114.2013.05.016]
[3]张瑞国,晋建华.体内自由基与Graves病研究新进展[J].国际放射医学核医学杂志,2009,33(4):240.[doi:10.3760/cma.j.issn.1673-4114.2009.04.015]
　ZHANG Rui-guo,JIN Jian-hua.Study progress on iree radicals and Graves disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):240.[doi:10.3760/cma.j.issn.1673-4114.2009.04.015]
[4]池翠萍.生物学系统内检测自由基方法的研究进展及其意义[J].国际放射医学核医学杂志,2009,33(4):252.[doi:10.3760/cma.j.issn.1673-4114.2009.04.019]
　CHI Cui-ping.Progress in measurement of free radicals in biological systems[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):252.[doi:10.3760/cma.j.issn.1673-4114.2009.04.019]
[5]倪瑾,蔡建明,吴秋业.富勒烯及其衍生物在核生物医学领域应用的研究现状[J].国际放射医学核医学杂志,2006,30(2):72.
　NI Jin,CAI Jian-ming,WU Qiu-ye.The research status of empty and metallofullerene derivatives for biological applications[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(5):72.
[6]仲恒高,童建.α粒子辐射与基因组不稳定性[J].国际放射医学核医学杂志,2004,28(6):267.
　ZHONG Heng-gao,TONG Jian.Alpha-particles radiation and genomic instability[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(5):267.
[7]陈剑,刘芬菊.抗辐射球菌辐射抗性机制的研究[J].国际放射医学核医学杂志,2003,27(5):225.
　CHEN Jian,LIU Fen-ju.Researches of radioresistance of Deinococcus radiodurans[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(5):225.
[8]范才,鞠桂芝.金属硫蛋白的抗电离辐射作用[J].国际放射医学核医学杂志,1998,22(2):91.
[9]方兴旺,李久强.90年代辐射化学研究[J].国际放射医学核医学杂志,1996,20(1):41.

备注/Memo

备注/Memo:
收稿日期:2008-07-17。
基金项目:国家自然科学基金(30770503);全军医药卫生"十一五"攻关项目(06G60)
通讯作者:蔡建明(E-mail:cjm882003@yahoo.com.cn)
更新日期/Last Update: 1900-01-01