[1]任振义,金一尊.Ku蛋白在肿瘤发生中的作用及其靶向抑制策略[J].国际放射医学核医学杂志,2008,32(5):305-307.
 REN Zhen-yi,JIN Yi-zun.The role of Ku protein in the development of carcinogenesis and potential strategy for silencing it[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(5):305-307.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第5期
页码:
305-307
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The role of Ku protein in the development of carcinogenesis and potential strategy for silencing it
作者:
任振义1 金一尊2
1. 310006 杭州, 杭州市第一人民医院呼吸内科;
2. 200032 上海, 复旦大学放射医学研究所
Author(s):
REN Zhen-yi1 JIN Yi-zun2
1. Department of Respiratory Medicine, First Hospital of Hangzhou, Hangzhou 310006, China;
2. Research Institute of Radiation Medicine, Fudan University, Shanghai 200032, China
关键词:
DNA双链断裂DNA修复肿瘤辐射耐受性
Keywords:
DNA double strand breakDNA repair NeoplasmsRadiation tolerance
摘要:
Ku蛋白参与辐射诱导的DNA损伤修复,严重影响着肿瘤细胞的辐射敏感性。细胞内Ku蛋白异常表达与肿瘤发生和发展存在密切关系。目前,研究者试图抑制Ku蛋白表达来增强肿瘤细胞的辐射敏感性,为进一步靶向治疗奠定基础。
Abstract:
The vital role of Ku protein is implement for DNA double strand break repair.Abnormal expression of Ku protein contributes to the development of carcinogenesis.The scientist are trying to enhance radiation-induced tumor control by inhibiting the Ku protein and have shown promising results.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2008-07-01。
基金项目:卫生部科研基金(wkj2005-2-051);杭州市科技局资助项目(20080333810)
通讯作者:任振义(E-mail:huxikel23@yahoo.com.cn)
更新日期/Last Update: 1900-01-01