[1]渠浩,王振军,陈大志,等.18F-氟代脱氧葡萄糖正电子放射导向手术在结直肠癌治疗中的初步应用[J].国际放射医学核医学杂志,2006,30(3):145-147.
　QU Hao,WANG Zhen-jun,CHEN Da-zhi,et al.The preliminary study using 18F-fluorodeoxyglucose positron-radioguided surgery for colorectal carcinoma operation[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):145-147.
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18F-氟代脱氧葡萄糖正电子放射导向手术在结直肠癌治疗中的初步应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第3期
页码:
145-147
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The preliminary study using 18F-fluorodeoxyglucose positron-radioguided surgery for colorectal carcinoma operation
作者:
渠浩1;  王振军1;  陈大志1;  王铁2;  韩进1;  杜燕夫1;  李敏哲1
1. 100020 北京, 首都医科大学附属北京朝阳医院普外科;
2. 100020 北京, 首都医科大学附属北京朝阳医院核医学科
Author(s):
QU Hao1;  WANG Zhen-jun1;  CHEN Da-zhi1;  WANG Tie2;  HAN Jin1;  DU Yan-fu1;  LI Min-zhe1
1. Department of Surgery, Beijing Chaoyang Hospital, Beijing 100020, China;
2. Department of Nuclear Medicine, Beijing Chaoyang Hospital, Beijing 100020, China
关键词:
结直肠肿瘤; 氟脱氧葡萄糖F18; 外科手术; 计算机辅助
Keywords:
Colorectal neoplasms; Fluorodeoxyglucose F18; Surgery; computer-assisted
分类号:
R817.4
摘要:
目的 报告18F-氟代脱氧葡萄糖(18F-FDG)应用于结直肠癌放射导向手术的方法和临床应用价值。方法 术前2h将18F-FDG111MBq静脉注射入结直肠癌患者体内,开腹后以γ探测仪探测肿瘤原发部位(T)及正常组织(NT),每隔1h测定一次,至手术开始后5h;对离体标本的上下两个断端及癌旁组织进行测定、对标本的各组系膜淋巴结进行测定,探索正电子放射导向手术(PRGS)的最佳术中探测时间。以T/NT≥1.5为阳性标准,计算PRGS对原发肿瘤的探测敏感性和特异性、对系膜淋巴结转移的敏感性及特异性。结果 PRGS的最佳术中探测时间为静脉给药后的第5到第6小时。PRGS对原发肿瘤的灵敏度为100%,特异度为71.9%;对淋巴结转移的灵敏度及特异度分别为83.3%和68.9%。结论 18F-FDGPRGS对结直肠癌的诊断、浸润范围和淋巴结转移的判断具有较高敏感性和特异性,对结直肠癌肿瘤切除范围和淋巴结清扫范围有一定的指导意义。
Abstract:
Objective To report the method and the value of positron nuclide-18F-fluorodeoxyglucose (18F-FDG) in radioguided surgery (RGS) in colorectal carcinoma.Methods Intravenously injected 111MBq 18F-FDG into 8 patients with colorectal carcinoma 2 hours before the operation. The detections were processed every hour and lasted five hours from the very beginning of the operations. We detected targets of tumors (T) and normal tissue (NT) by using a portable gamma-detecting probe. Additionally, we detected the proximal and distal edge of excised specimens, the tissue of colon wall 2cm to upper and lower edges of primary tumors of specimens, the lymph nodes of specimens. We were able to find the optimal time for posiron radioguidocl surgery (PRGS). Choosing the positive criterion T/NT ≥ 1.5, We were able to calculate the sensitivity of PRGS of the primary tumor, the specificity of colon wall tissue and excised edge, the sensitivity and specificity of lymph nodes.Results The optimal time for PRGS is the 5th~6th hour after intravenous injection of the 18F-FDG. The sensitivity of primary tumor detection is 100%. The specificity of colon wall tissue and excised edge is 71.9%. The sensitivity and specificity of lymph nodes detections are 83.3% and 68.9%.Conclusion PRGS had high sensitivity and specificity in judging the infiltrating range and lymph nodes metastasis in colorectal carcinoma.

参考文献/References:

1 田嘉禾.正电子发射体层显像(PET)图谱.北京.中国协和医科大学出版社,2002.20.
2 田嘉禾.正电子发射体层显像(PET)图谱.北京.中国协和医科大学出版社,2002.18.
3 Di Carlo V, Badellino F, Stella M, et al. Role of B72.3 iodine 125-labeled monoclonal antibody in colorectal cancer detection by radioimmunoguided surgery. Surgery, 1994, 115(2):190-198.
4 Schneebaum S, Troitsa A, Haddad R, et al. Immunoguided lymph node dissection in colorectal cancer:a new challenge?. World J Surg, 2001, 25(12):1495-1499.
5 Agnese DM, Abdessalam SF, Burak WE, et al. Pilot study using a humanized CC49 monoclonal antibody (HuCC49[DELTA] CH2)to localize recurrent colorectal carcinoma. Ann Surg Oncol, 2004,11(2):197-202.
6 董爱生.18F-FDG在结直肠癌中的临床应用价值.国外医学·放射医学核医学分册,2004,28(1):12-14.
7 王珏琦, 孙玉鹗.肺癌放射免疫导向手术的动物实验研究.中国肺癌杂志,2000,3(1):46-49.

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备注/Memo

备注/Memo:
收稿日期:2006-04-17。
通讯作者:渠浩(E-mail:quh@sohu.com)
更新日期/Last Update: 1900-01-01