[1]许建华.Egr-1基因的辐射生物学效应研究进展[J].国际放射医学核医学杂志,2002,26(2):76-79.
 XU Jian-hua.Advances in the research of the role of Egr-1 gene in cells’ response to ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(2):76-79.
点击复制

Egr-1基因的辐射生物学效应研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第2期
页码:
76-79
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Advances in the research of the role of Egr-1 gene in cells’ response to ionizing radiation
作者:
许建华
215007 江苏苏州, 苏州大学核医学院放射毒理系
Author(s):
XU Jian-hua
Nuclear Medicine School, Suzhou University, Jiangsu Suzhou 215007, China
关键词:
Egr-1细胞凋亡细胞周期辐射敏感性
Keywords:
early growth response-1apoptosiscell cycleradiation sensitivity
分类号:
Q503;Q274
摘要:
Egr-1(early growth response-1)基因是一系列"立即早期基因(immediateearly gene)"之一,参与细胞的多种辐射生物效应。研究表明,Egr-1在多种正常细胞和肿瘤细胞受到电离辐射后的早期就能被激活,它的激活表达与辐照后细胞的生长、周期、凋亡等的改变密切相关。另外,Egr-1基因调控序列具有辐射可诱导特性,这一特点使其具有潜在的临床和基因工程生产应用前景。
Abstract:
Egr-1(early growth response-1)gene is an important member of the "Immediate Early Growth" gene family,participating in multiple radiation biological effects of the irradiated cells.Studies have shown that after ionizing radia-tion,Egr-1 gene can be activated at an early stage in many types of tumor and normal cells.Its actitivation and the conse-quent expression is believed to have a close relation to the change in cell growth,cell cycle and apoptosis of the irradiat-ed cells. Additionally,the radiation-inducible property of the Egr-1 gene regulating sequence confers potential clinical and genetic engineering uses.

参考文献/References:

[1] Shimizu N,Ohta M,Fujiwara C, et al. A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acet-ate-stimulated HL-60 differentiation[J].J Biol Chem,1992,111(2):272-277.
[2] Datta R,Rubin E,Sukhatme V, et al. Ionizing radiation activates transcription of the EGR1 gene via CArG elements[J].Proc Natl Acad Sci USA,1992,89(21):10149-10153.
[3] Ahmed MM,Kolaparthi V,Sana MF, et al. Egr-1 induction is required for maximal radiosensitivity in A375-C6 melanoma cells[J].J Biol Chem,1996,271(46):29231-29237.
[4] HallahanDE,Sukhatme VP,Sherman ML, et al. Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN[J].Proc Natl Acad Sci USA,1991,88(6):2156-2160.
[5] Huang RP,Adamson ED. A biological role for Egr-1 in cell survival following ultra-violet irradiation[J].Oncogene,1995,10(3):467-475.
[6] Dennis E,Hallahan DE,Edward D, et al. c-jun and Egr-1 participate in DNA synthesisand cell survial in response to ionizing radiation e-xposure[J].J Biol Chem,1995,270(51):30303-30309.
[7] Yan YX,Nakawa H,Lee MH, et al. Transforming growth factor-alpha enh-ances cyclin D1 transcription through the binding of early growth response protein to a cis-regnlatory element in the cyclin D1 pr-omoter[J].J Biol Chem,1997,272(52):33181-33190.
[8] Ahmed MM,Stephen FS,Kolaparthi V, et al. Ionizing radiation-induc-ible apoptosis in the absence of p53 linked to transcription fact-or Egr-1[J].J Biol Chem,1997,272(52):33056-33061.
[9] Anindita D,Damodaran C,Swatee D, et al. Ionizing radiation down-reg-ulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis[J].J Biol Chem,2001,276(5):3279-3286.
[10] Dinkel A,Aicher W,Haas C, et al. Transcription factor Egr-1 activity down-regulates Fas and CD23 expression in B cells[J].J Imm-unol,1997,159(6):2678-2684.
[11] Li-Weber M,Laur O,Krammer PH, et al. Novel Egr/NF-AT composite sites me-diate activation of the CD95(APO-1/Fas)ligand promoter in respo-nse to T cell stimulation[J].Eur J Immunol,1999,29(9):3017-3027.
[12] Huang RP,Fan Y,de Belle I, et al. Egr-1 inhibits apoptosis during the UV response:correlation of cell survival with Egr-1 phosphor-ylation[J].Cell Death Differ,1998,5(1):96-106.
[13] Weichselbaum RR,Hallahan DE,Beckett MA, et al. Gene therapy targeted by radiation preferentially radiosensitizes tumor cells[J].Cancer Res,1994,54(16):4266-4269.
[14] Weichselbaum RR,Hallahan DE,Sukhatme VP, et al. Gene therapy targeted by ionizing radiation[J].Int J Radiat Oncol Biol Phy,1992,24(3):565-567.
[15] Seung LP,Mauceri HJ,Beckett MA, et al. Genetic radiotherapy overcomes tumor resistance to cytotoxic agents[J].Cancer Res,1995,55(23):5561-5565.
[16] Kawashita Y,Ohtsuru A,Kaneda Y, et al. Regression of hepatocellular carcinoma in vitro and in vivo by radiosensitizing suicide gene therapy under the inducible and spatial control of radiation[J].Hum Gene Ther,1999,10(9):1509-1519.
[17] Takahashi T,Namiki Y,hno T, et al. Induction of the suicide HSV-TK gene by activation of the Egr-1 promoter with radioisotopes[J].Hum Gene Ther,1997,8(7):827-833.

相似文献/References:

[1]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[2]张俊伶,薛晓蕾,李源,等.富氢水对电离辐射引起胸腺细胞损伤的影响[J].国际放射医学核医学杂志,2015,39(5):358.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 001]
 zhang junling,xue xiaolei,li yuan,et al.effects of hydrogen-rich water on radiation-induced thymus injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):358.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 001]
[3]安淑娴,宋少莉,黄钢.放射性核素标记的凋亡显像剂的研究进展[J].国际放射医学核医学杂志,2015,39(6):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
 An Shuxian,Song Shaoli,Huang Gang.Recent advances in apoptosis imaging using radionuclide-labeled tracers[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
[4]徐畅,王彦,杜利清,等.shRNA干扰沉默Net1基因对电离辐射损伤反应的影响[J].国际放射医学核医学杂志,2013,37(3):135.[doi:10.3760/cma.j.issn.1673-4114.2013.03.002]
 XU Chang,WANG Yan,DU Li-qing,et al.The effects of short hairpin RNA-mediated silencing Net1 on ionizing radiation-induced damage responses[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):135.[doi:10.3760/cma.j.issn.1673-4114.2013.03.002]
[5]郭艳婷,张鹏飞,刘强.Smac与肿瘤放射治疗[J].国际放射医学核医学杂志,2013,37(5):309.[doi:10.3760/cma.j.issn.1673-4114.2013.05.014]
 GUO Yan-ting,ZHANG Peng-fei,LIU Qiang.Effects of Smac on tumor radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):309.[doi:10.3760/cma.j.issn.1673-4114.2013.05.014]
[6]邓惠兴,马爱群.核医学影像技术在心肌炎诊断中的应用[J].国际放射医学核医学杂志,2009,33(1):39.[doi:10.3760/cma.j.issn.1673-4114.2009.01.039]
 DENG Hui-xing,MA Ai-qun.The application of radionuclide imaging technology in myocarditis[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):39.[doi:10.3760/cma.j.issn.1673-4114.2009.01.039]
[7]尹培,边艳珠.体内凋亡细胞显像的研究进展[J].国际放射医学核医学杂志,2009,33(5):279.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.007]
 YIN Pei,BIAN Yan-zhu.Development of apoptosis imaging in vivo[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):279.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.007]
[8]张颖,林军.125I粒子治疗对肝癌细胞凋亡及细胞周期的影响[J].国际放射医学核医学杂志,2009,33(4):193.[doi:10.3760/cma.j.issn.1673-4114.2009.04.001]
 ZHANG Ying,LIN Jun.Effects of 125I seed brachytherapy on apoptosis and cell cycle distribution in hepatoma carcinoma cells[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):193.[doi:10.3760/cma.j.issn.1673-4114.2009.04.001]
[9]杨岩,王娟,王冠军.低剂量辐射对人骨髓间充质干细胞影响的研究[J].国际放射医学核医学杂志,2008,32(3):183.
 YANG Yan,WANG Juan,WANG Guan-jun.Study on human mesenchymal stem cells from bone marrow pretreated with low dose radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(2):183.
[10]张敬勉,赵新明,王建方,等.99Tc-亚甲基二膦酸盐与153Sm-乙二胺四亚甲基膦酸对骨侵袭和骨质溶解抑制作用的对比研究[J].国际放射医学核医学杂志,2008,32(6):321.
 ZHANG Jing-mian,ZHAO Xin-ming,WANG Jian-fang,et al.The comparative study of inhibitory effects of 99Tc-methylenediphosphonate and 153Sm-ethylene diamine tetramethylene phosphonic acid on bone invasion and osteolysis[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(2):321.

备注/Memo

备注/Memo:
收稿日期:2001-10-15。
作者简介:许建华(1975-),男,江苏昆山人,硕士研究生,主要从事电离辐射毒理学相关研究。
更新日期/Last Update: 1900-01-01