[1]杜华.p53在调节细胞周期阻滞和细胞凋亡中的作用及其机制[J].国际放射医学核医学杂志,2002,26(2):79-83.
　DU Hua.The regulating mechanism of p53 during cell cycle arrest and apoptosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(2):79-83.
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p53在调节细胞周期阻滞和细胞凋亡中的作用及其机制(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第2期
页码:
79-83
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The regulating mechanism of p53 during cell cycle arrest and apoptosis
作者:
杜华
510515 广州, 第一军医大学热卫系放射医学教研室
Author(s):
DU Hua
Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039, China
关键词:
p53; 细胞周期; 细胞凋亡
Keywords:
p53; cell cycle; apoptosis
分类号:
Q756
摘要:
p53作为抑癌基因,在各种应激情况下(包括电离辐射所致DNA损伤、核苷酸缺失、低氧或癌基因激活)调控细胞周期进程和细胞凋亡过程。本文综述了p53及其下游分子在细胞周期和细胞凋亡中的作用,在此基础上探讨p53在选择细胞周期阻滞和细胞凋亡中的影响因素。
Abstract:
p53,acting as a tumour suppressor gene,regulates the system of cell cycle and apoptosis when cells confront a variety of stress including DNA damage responding to ionizing radiation,nucleotide depletion,hypoxia or oncogene activation. In this article,the role and targets of p53 during cell cycle and apoptosis are reviewed. On the basis of it,we question factors of the decision to undergo growth arrest versus apoptosis in response to p53 expression.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2002-2-7。
作者简介:杜华(1976-),女,安徽合肥人,硕士研究生,主要从事放射生物学研究。
更新日期/Last Update: 1900-01-01