[1]程兵.99Tcm-MIBI显像检测乳腺癌多药耐药[J].国际放射医学核医学杂志,2002,26(2):67-71.
 CHENG Bing.The appliciation of 99Tcm-MIBI scintimammography to diagnose multidrug resistance of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(2):67-71.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第2期
页码:
67-71
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The appliciation of 99Tcm-MIBI scintimammography to diagnose multidrug resistance of breast cancer
作者:
程兵
450052 郑州, 郑州大学第一附属医院核医学科
Author(s):
CHENG Bing
Department of nuclear medicine, The first affiliated Hospital, Zhengzhou University, Henan Zhengzhou 450052, China
关键词:
sup>99Tcm-甲氧基异丁基异腈P-糖蛋白谷胱甘肽硫转移酶乳腺癌多药耐药
Keywords:
99Tcm-sestamibiP-glycoproteinglutathione S-transferasebreast cancermultidrug resistance
分类号:
R817.4;R737.9
摘要:
探讨了乳腺癌组织的多药耐药现象的主要机制及P-糖蛋白(P-gp)、胎盘型谷胱甘肽硫转移酶(GST-π)与99Tcm-MIBI显像的关系。尽管文献报道的实验结果不尽相同,但作为一种功能显像技术,99Tcm-MIBISPECT显像能够用来研究乳腺癌细胞P-gp的表达,可以在体外无创性检测乳腺癌多药耐药,为指导乳腺癌的治疗提供参考。
Abstract:
This article discussed the main mechanism of multidrug resistance of breast cancer tissues, and the correla-tion between technetium-99m sestamibi (99Tcm-MIBI) breast imaging results, with the expression of drug resistance pro-teins P-glycoprotein and glutathione-S-transfease-π in human breast cancer.Though not all the results reported before matched each other, as a kind of a noninvasive simple functional test imaging technology in vitro, SPECT can be used to diagnose P-glycoprotein expression in breast cancer, and can be used to predict chemotherapy response.

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备注/Memo

备注/Memo:
收稿日期:2001-8-20。
作者简介:程兵(1971-)男,河南郑州人,硕士研究生,主要从事肿瘤核医学研究。
更新日期/Last Update: 1900-01-01