[1]朱光旭,王小华.肿瘤辐射敏感性与细胞凋亡[J].国际放射医学核医学杂志,2000,24(2):78-82.
 ZHU Guang-xu,Wang Xiao-hua.Tumor radiosensitivity and apoptosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(2):78-82.
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肿瘤辐射敏感性与细胞凋亡(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
24
期数:
2000年第2期
页码:
78-82
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Tumor radiosensitivity and apoptosis
作者:
朱光旭 王小华
400038 重庆, 中国人民解放军第三军医大学全军复合伤研究所
Author(s):
ZHU Guang-xu Wang Xiao-hua
Institute of Combined Injury, Third Military Medical University, Chongqing 400038, China
关键词:
辐射敏感性细胞凋亡信号途径基因表达调控
Keywords:
radiosensitivityapoptosissignaling pathwayregulation of gene expression
分类号:
R818.03
摘要:
辐射敏感性是肿瘤细胞复杂的生物学现象,在辐射诱导的细胞反应中具有不同的组织细胞类型特异性。肿瘤瘤射敏感性与辐射诱导的细胞凋亡密切相关,并受P53及其相关蛋白、Bcl-2基因家族蛋白、Fas及神经鞘磷脂-神经酰胺介导的信号途径、caspases级联反应等调控。
Abstract:
Radiosensitivity is a complex phenomenon in tumor cells and there exist special biological effects in different types of tissues’ cells in inadiation-induced cell responses. Tumor radiosentivity is tightly connected with irradiation-induced apoptosis and is regulated by many protein products of apoptosis-related genes such as p53 and related proteins, Bcl-2 gene family proteins, Fas and sphingomyelin/ceramide-mediated signalling pathways and caspases cascade etc.

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备注/Memo

备注/Memo:
收稿日期:2000-01-10。
作者简介:朱光旭(1972-),男,贵州瓮安人,第三军医大学全军复合伤研究所生物化学与分子生物学研究室检验技师,硕士研究生,主要从事辐射对肿瘤细胞信号转导影响的研究;王小华(1972-),女,重庆忠县人,第三军医大学全军复合伤研究所生物化学与分子生物学研究室检验技师,硕士研究生,主要从事辐射对肿瘤细胞信号转导影响的研究。
更新日期/Last Update: 1900-01-01