[1]郁春景,吴翼伟,万卫星.P-gp功能的PET显像剂的研究进展[J].国际放射医学核医学杂志,2014,38(6):403-407.[doi:10.3760/cma.j.issn.1673-4114.2014.06.013]
 Yu Chun-jing,Wu Yi-wei,Wan Wei-xing.Progress in PET imaging evaluating of P-gp function[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(6):403-407.[doi:10.3760/cma.j.issn.1673-4114.2014.06.013]
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P-gp功能的PET显像剂的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第6期
页码:
403-407
栏目:
出版日期:
2014-11-25

文章信息/Info

Title:
Progress in PET imaging evaluating of P-gp function
作者:
郁春景1 吴翼伟2 万卫星1
1. 无锡市第四人民医院核医学科, 214062;
2. 苏州大学附属第一医院核医学科, 215006
Author(s):
Yu Chun-jing1 Wu Yi-wei2 Wan Wei-xing1
Department of Nuclear Medicine, the Fourth People’s Hospital, Wuxi 214062, China
关键词:
P-糖蛋白正电子发射断层显像术放射性示踪剂
Keywords:
P-glycoproteinPositron emission tomographyRadiotracer
DOI:
10.3760/cma.j.issn.1673-4114.2014.06.013
摘要:
肿瘤对化疗药物产生耐药性是肿瘤治疗失败的主要原因,引起肿瘤对化疗药物耐药的重要机制是ATP结合盒(ABC)转运蛋白的过度表达。P-糖蛋白(P-gp)是ABC转运蛋白超家族中研究最广、最深入的一类转运蛋白,目前检测P-gp主要依赖于组织活检或术后病理组织在体外进行定性、定量分析,这些检测方法受取材技术、肿瘤标本差异等因素的限制,因此,寻找一种无创性、可以动态检测肿瘤多药耐药的方法就显得尤为重要。目前许多18F、11C标记的P-gp底物及抑制剂的正电子显像剂已经进行基础研究,部分进入了临床试验阶段。该文对P-gp的PET显像剂现状进行综述。
Abstract:
The resistance of malignant tumors to chemotherapy is a major cause of treatment failure.One important mechanism in this resistance is the overexpression of adenosine triphosphate-binding cassette transporters.The best-characterize member of this superfamily of transporters is P-glycoprotein (P-gp).The qualitative and quantitative ananlysis of P-gp mainly depends on the tissue biopsy or postoperative pathologic tissue in vitro.It is important to find a method of noninvasive and dynamic monitoring tumor multidrug resistance.Many positron imaging agent of P-gp substrates and inhibitors have been researched,and part of them have been researched in clinic.In this review,the current status is summarized on PET imaging and P-gp function.

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备注/Memo

备注/Memo:
收稿日期:2014-02-11。
基金项目:国家自然科学基金主任基金资助项目(81341048)
通讯作者:吴翼伟(Email:wuyiwei3988@gmail.com);万卫星(Email:wwxjs@126.com)
更新日期/Last Update: 1900-01-01