[1]李骁扬,田野.动态增强磁共振成像在抗肿瘤血管药物早期临床试验中的应用[J].国际放射医学核医学杂志,2014,38(5):309-314.[doi:10.3760/cma.j.issn.1673-4114.2014.05.008]
 Li Xiao-yang,Tian Ye.The application of dynamic contrast-enhanced magnetic resonance imaging in early-phase clinical trials of antivascular medicine for malignant tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(5):309-314.[doi:10.3760/cma.j.issn.1673-4114.2014.05.008]
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动态增强磁共振成像在抗肿瘤血管药物早期临床试验中的应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第5期
页码:
309-314
栏目:
出版日期:
2014-09-25

文章信息/Info

Title:
The application of dynamic contrast-enhanced magnetic resonance imaging in early-phase clinical trials of antivascular medicine for malignant tumors
作者:
李骁扬 田野
苏州大学附属第二医院放疗科, 215004
Author(s):
Li Xiao-yang Tian Ye
Depantment of Radiology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
关键词:
磁共振成像动态增强肿瘤抗血管治疗药物评价
Keywords:
Magnetic resonance imagingDynamic contrast-enhancedTumorsAntivasculra therapyDrug evaluation
DOI:
10.3760/cma.j.issn.1673-4114.2014.05.008
摘要:
动态增强磁共振成像(DCE-MRI)正逐渐被应用于抗肿瘤血管药物的早期临床试验。该文将对传统临床试验药效评价体系应用于抗肿瘤血管分子靶向药物研发中所存在的问题、DCE-MRI的相应技术原理、DCE-MRI临床应用现状与其在临床试验中的优势、存在的问题与展望做一综述,并列举一些近年来应用DCE-MRI技术进行抗肿瘤血管分子靶向药物临床试验的典型案例。
Abstract:
The development and research of antivascular medicine has already exerted challenges for traditional clinical trials and its evaluation system. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), as an uninvasive method to visualize and assess vascular structure and function, has been gradually utilized in clinical trials of antivascular medicine and improving stepwise with a view to further detecting angiogenesis of tumor and effects of medicine. This review will articulate on defects of traditional evaluation system in clinical trials of antivascular medicine, technological characteristics of DCE-MRI as well as pros and cons of its application in clinical trials. The detailed utilization of DCE-MRI in some early phase clinical trials during recent years will also be orchestrated in this review.

参考文献/References:

[1] Leach MO,Brindle KM,Evelhoch JL,et al.The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging:issues and recommendations[J].Br J Cancer,2005,92(9):1599-1610.
[2] Patlak CS,Blasberg RG.Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data.Generalizations[J].J Cereb Blood Flow Metab,1985,5(4):584-590.
[3] Tofts PS,Kermode AG.Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging.1.Fundamental concepts[J].Magn Reson Med,1991,17(2):357-367.
[4] St Lawrence KS,Lee TY.An adiabatic approximation to the tissue homogeneity model for water exchange in the brain:I.Theoretical derivation[J].J Cereb Blood Flow Metab,1998,18(12):1365-1377.
[5] Tofts PS,Brix G,Buckley DL,et al.Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer:standardized quantities and symbols[J].J Magn Reson Imaging,1999,10(3):223-232.
[6] Leach MO,Morgan PS,Tofts PS,et al.Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging[J].Eur Radiol,2012,22(7):1451-1464.
[7] Tozer GM.Measuring tumor vascular response to antivascular and antiangiogenic drugs[J].Br J Radiol,2003,76(1):S23-35.
[8] Gregorc V,Citterio G,Vitali G,et al.Defining the optimal biological dose of NGR-hTNF,a selective vascular targeting agent,in advanced solid tumours[J].Eur J Cancer,2010,46(1):198-206.
[9] Murukesh N,Dive C,Jayson GC,et al.Biomarkers of angiogenesis and their role in the development of VEGF inhibitors[J].Br J Cancer,2010,102(1):8-18.
[10] Padhani AR.MRI for assessing antivascular cancer treatments[J].Br J Radiol,2003,76(1):S60-80.
[11] Yung WK,Friedman H,Conrad C,et al.A phase I trial of single-a-gent PTK 787/ZK 2225894(PTK/ZK),an oral VEGFR tyrosine kinase inhibitor,in patients with recurrent glioblastoma multiforme[C].Chicago:American Society of Clinical Oncology,2003:395.
[12] Cha S,Knopp EA,Johnson G,et al.Dynamic contrast-enhanced T2-weighted MR imaging of recurrent malignant gliomas treated with thalidomide and carboplatin[J].AJNR Am J Neuroradiol,2000,21(5):881-890.
[13] Parker GJ,Suckling J,Tanner SF,et al.Probing tumor microvascularity by measurement,analysis and display of contrast agent uptake kinetics[J].J Magn Reson Imaging,1997,7(3):564-574.
[14] Anwar RP,Janet EH.Dynamic contrast-enhanced MRI studies in oncology with an emphasis on quantification,validation and human studies[J].Clin Radiol,2001,56(8):607-620.
[15] Buckley DL,Drew PJ,Mussurakis S,et al.Microvessel density of invasive breast cancer assessed by dynamic Gd-DTPA enhanced MRI[J].J Magn Reson Imaging,1997,7(3):461-464.
[16] Stomper PC,Winston JS,Herman S,et al.Angiogenesis and dynamic MR imaging gadolinium enhancement of malignant and benign breast lesions[J].Breast Cancer Res Treat,1997,45(1):39-46.
[17] Knopp MV,Weiss E,Sinn HP,et al.Pathophysiologic basis of contrast enhancement in breast tumors[J].J Magn Reson Imaging,1999,10(3):260-266.
[18] O’Connor JP,Clamp AR,Carano RA,et al.Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor:insights from imaging[J].Clin Cancer Res,2009,15(21):6674-6682.
[19] Dowlati A,Robertson K,Cooney F,et al.A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4-phosphate on a single-dose intravenous schedule inpatients with advanced cancer[J].Cancer Res,2002,62(12):3408-3416.
[20] Galbraith SM,Rustin GJ,Lodge MA,et al.Effects of 5,6-dimethylxanthenone-4-acetic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging[J].J Clin Oncol,2002,20(18):3826-3840.
[21] O’Cornor JP,Jackson A,Parker GJ,et al.Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies[J].NatRev Clin Oncol,2012,9(3):167-177.
[22] Evelhoch JL.Key factors in the acquisition of contrast kinetic data for oncology[J].J Magn Reson Imaging,1999,10(3):254-259.
[23] Thorpe PE.Vascular targeting agents as cancer therapeutics[J].Clin Cancer Res,2004,10(2):415-427.
[24] McPhail LD,Griffiths JR,Robinson SP.Assessment of tumor response to the vascular disrupting agents 5,6-dimethylxanthenone-4-acetic acid or combretastatin-A4-phosphate by intrinsic susceptibility magnetic resonance imaging[J].Int J Radiat Oncol Biol Phys,2007,69(4):1238-1245.
[25] Koh DM,Blackledge M,Collins DJ,et al.Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin-A4 phosphate and bevacizumab in a two-centre phase I clinical trial[J].Eur Radiol,2009,19(11):2728-2738.
[26] Galbraith SM,Maxwell RJ,Lodge MA,et al.Combretastatin-A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging[J].J Clin Oncol,2003,21(15):2831-2842.
[27] Gregorc V,Citterio G,Vitati G,et al.Defining the optimal biological dose of NGR-hTNF,a selective vascular targeting agent,in advanced solid tumours[J].Eur J Cancer,2010,46(1):198-206.
[28] Jonker DJ,Rosen LS,Sawyer MB,et al.A phase I study to determine the safety,pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor,brivanib,in patients with advanced or metastatic solid tumors[J].Ann Oncol,2011,22(6):1413-1419.
[29] Jackson A,O’Connor JP,Parker GJ,et al.Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging[J].Clin Cancer Res,2007,13(12):3449-3459.
[30] O’Connor JP,Jackson A,Parker GJ,et al.DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents[J].Br J Cancer,2007,96(2):189-195.
[31] Rehman S,Jayson GC.Molecular imaging of antiangiogenic agents[J].Oncologist,2005,10(2):92-103.
[32] Congress U.S.Food and drug administration modernization act of 1997[R].Virginia:U.S.FDA,1997:105-115.
[33] Hahn OM,Yang C,Medved M,et al.Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma[J].J Clin Oncol,2008,26(28):4572-4578.
[34] Dahut WL,Madan RA,Karakunnel JJ,et al.Phase Ⅱ clinical trial of cediranib in patients with metastatic castration-resistant prostate cancer[J].BJU Int,2013,111(8):1269-1290.
[35] Kreisl TN,Zhang W,Odia Y,et al.A phase Ⅱ trial of single-agent bevacizumab in patients with recurrent anaplastic glioma[J].Neuro Oncol,2011,13(10):1143-1150.
[36] Lockhart AC,Rosenberg ML,Dupont J,et al.Phase I study of intravenous vascular endothelial growth factor trap,aflibercept,in patients with advanced solid tumors[J].J Clin Oncol,2010,28(2):207-214.
[37] Zhu AX,Sahani DV,Duda DG,et al.Efficacy,safety,and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma:a phase Ⅱ study[J].J Clin Oncol,2009,27(18):3027-3035.
[38] Liu G,Hope S,Wilding G,et al.Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736,an oral angiogenesis inhibitor,in patients with advanced solid tumors:results from a phase I study[J].J Clin Oncol,2005,23(24):5464-5473.

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备注/Memo

备注/Memo:
收稿日期:2014-01-13。
基金项目:国家自然科学基金(81172128,81372411)
通讯作者:田野(Email:dryetian@hotmail.com)
更新日期/Last Update: 1900-01-01