[1]刘岩,杨爱民,欧阳雁,等.放射性核素唾液腺显像及抗核抗体联合检查在干燥综合征中的诊断价值[J].国际放射医学核医学杂志,2014,38(4):219-222.[doi:10.3760/cma.j.issn.1673-4114.2014.04.003]
　Liu Yan,Yang Aimin,Ou Yangyan,et al.The diagnostic value of joint inspection of radionuclide salivary gland scintigraphy and antinuclear antibody examination in Sjögren’s syndrome patients[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):219-222.[doi:10.3760/cma.j.issn.1673-4114.2014.04.003]
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放射性核素唾液腺显像及抗核抗体联合检查在干燥综合征中的诊断价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第4期
页码:
219-222
栏目:
出版日期:
2014-07-25

文章信息/Info

Title:
The diagnostic value of joint inspection of radionuclide salivary gland scintigraphy and antinuclear antibody examination in Sjögren’s syndrome patients
作者:
刘岩1;  杨爱民1;  欧阳雁1;  高蕊1;  程虎1;  乔友梅2;  张芬茹1
1. 西安交通大学医学院第一附属医院核医学科, 710061;
2. 西安市雁塔区中医医院内科, 71006l
Author(s):
Liu Yan1;  Yang Aimin1;  Ou Yangyan1;  Gao Rui1;  Cheng Hu1;  Qiao Youmei2;  Zhang Fenru1
Department of Nuclear Medicine, the First Affiliated Hospital of Xi’an Jiao Tong University Medical School, Xi’an 710061, China
关键词:
干燥综合症; 抗体; 抗核; 放射性核素现象; 唾液腺
Keywords:
Sjogren’s syndrome; Antibodies;  Antinuclear; Radionuclide imaging; Salivary gland
DOI:
10.3760/cma.j.issn.1673-4114.2014.04.003
摘要:
目的 探讨放射性核素唾液腺动态显像及抗核抗体联合检查在干燥综合征中的诊断价值。方法 对临床已确诊的30例原发性干燥综合征患者分别进行放射性核素唾液腺动态显像及抗核抗体联合检查,回顾性研究其在该病中的诊断价值。结果 30例干燥综合征患者中,抗核抗体检查阳性患者19例,占63.3%,阴性11例,占36.7%;唾液腺动态显像阳性患者24例,占80%,阴性6例,占20%;唾液腺动态显像与抗核抗体联合检查阳性率为100%(30/30),显著高于放射性核素唾液腺动态显像(P<0.05)及抗核抗体检查(P<0.01)。结论 唾液腺动态显像及抗核抗体联合检查在干燥综合征筛查、诊断及评价唾液腺功能损伤程度等方面具有非常重要的临床价值。
Abstract:
Objective To investigate the diagnosis value of the joint inspection of radionuclide dynamic images of salivary gland and antinuclear antibody examination in Sjögren’s syndrome (SS)patients.Methods Radionuclide dynamic images and antinuclear antibody examination were applied in 30 patients who were confirmed as SS clinically.The diagnostic value of these 2 methods in SS was studied retrospectively.The positive rates were calculated according to the classical definitions.Results Out of the 30 SS cases,antinuclear antibody examination detected 19 cases (63.3% of the cohort).The other 11 cases turned out to be false negative.Compared with antinuclear antibody examination,dynamic salivary gland scintigraphy identified 24 SS cases,and the positive rate was 80%.The positive rate of the joint examination were calculated as 100%,significantly higher than that of radionuclide dynamic images of salivary gland (P<0.05),or antinuclear antibody test (P<0.01).Conclusion Joint inspection of dynamic salivary gland images and antinuclear antibody tests has very important clinical value in SS screening,diagnosing and evaluating of salivary gland dysfunction.

参考文献/References:

[1] Baum JB, Fox PC, Neumann RD. The salivary glands.//Herbert JC,Eckelman WC, Neumann RD. Nuclear Medicine:Diagnosis and Therapy[M]. New York:Thieme Medical, 1996:439-444.
[2] 陈跃,Hongming Zhuang,杨吉刚.放射性核素唾液显像的临床应用进展[J].国际放射医学核医学杂志,2012,36(1):13-15.
[3] Tonami H, Higashi K, Matoba M, et al. A comparative study between MR sialography and salivary gland scintigraphy in the diagnosis of Sjögren syndrome[J]. J Comput Assist Tomogr, 2001, 25(2):262-268.
[4] Booker J, Howarth D, Taylor L, et al. Appropriate utilization of semi-quantitative analysis in salivary scintigraphy[J]. Nucl Med Commun,2004,25(12):1203-1210.
[5] Adams BK, Al Attia HM, Parkar S. Salivary gland scintigraphy in Sjögren’s syndrome:are quantitative indices the answer?[J]. Nucl Med Commun, 2003, 24(9):1011-1016.
[6] Taura S, Murata Y, Aung W, et al. Decreased thyroid uptake of Tc99m pertechnetate in patients with advanced-stage Sjögren syndrome:evaluation using salivary gland scintigraphy[J]. Clin Nucl Med, 2002, 27 (4):265-269.
[7] Garcí:a-Carrasco M, Ramos-Casals M, Rosas J, et al. Primary Sjögren syndrome:clinical and immunologic disease patterns in a cohort of 400 patients[J]. Med(Baltimore), 2002, 81(24):270-280.
[8] Ramos-Canals M, Brito-Zeró:n P, Sisó:-Almirall A, et al. Primary Sjögren syndrome[J]. Praxis (Berm 1994), 2012, 101 (24):1565-1571.
[9] 林天生,王申,陈为民.99TcmO4-腮腺动态显像在干燥综合征诊断中的价值[J].海南医学院学报,2012,18(7):977-980.
[10] 宋晏,陈正福,张学敏,等.唾液腺核素显像在诊断干燥综合征中的临床意义[J].航空航天医学杂志,2013,24(12):1541-1542.
[11] 张晓明,冯压,张文军,等.核素唾液腺动态显像定量分析评价干燥综合征唾液腺功能的研究[J].中国医学影像技术,2007, 23(4):608-612.
[12] 谭立明,王外梅,樊有龙,等.干燥综合征患者特异性抗体的检测[J].江西医学检验,1997,15(2):11-13.
[13] 向阳,周陆.唾液腺动态显像定量分析对原发干燥综合征的诊断及评估病变程度的临床研究[J].中国全科医学,2013, 16(24):2809-2812.

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备注/Memo

备注/Memo:
收稿日期:2014-01-20。
基金项目:陕西省科技攻关项目(2007k1406(9))
通讯作者:杨爱民(Email:yangaimin@mail.xjtu.edu.cn)
更新日期/Last Update: 1900-01-01