[1]姚红霞,张金山.微波消融和131I-肿瘤细胞核人鼠嵌合单克隆抗体联合治疗肺癌[J].国际放射医学核医学杂志,2012,36(5):264-268,306.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.002]
　YAO Hong-xia,ZHA NG Jin-shan.Combination of microwave ablation and 131I labeled tumor necrosis therapy chimeric antibody in the treatment of lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(5):264-268,306.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.002]
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微波消融和131I-肿瘤细胞核人鼠嵌合单克隆抗体联合治疗肺癌(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第5期
页码:
264-268,306
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Combination of microwave ablation and 131I labeled tumor necrosis therapy chimeric antibody in the treatment of lung cancer
作者:
姚红霞;  张金山
广州医学院第三附属医院核医学科, 广州 510150
Author(s):
YAO Hong-xia;  ZHA NG Jin-shan
Department of Nuclear Medicine, the Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China
关键词:
肺肿瘤; 微波消融; 碘放射性同位素; 放射免疫疗法; 抗体; 单克隆
Keywords:
Lung neoplasms; Microwave ablation; Iodine radioisotopes; Radioimmunotherapy; Antibodies;  monoclonal
DOI:
10.3760/cnla.j.issn.1673-4114.2012.05.002
摘要:
微波消融(MWA)被认为是一种肺癌局部控制的新型微创治疗方法,它通过超声、CT或MRI引导经皮穿刺导入微波天线,利用微波产热机制,高温原位灭活肿瘤细胞,对原发性周围型肺癌或转移性肺癌局部控制率较高,但对于瘤体负荷较大的肿瘤病灶(如肿瘤直径在3cm以上)或近肺门的中心型肺癌、多发转移性肺癌的治疗风险大、疗效欠佳。以变性和(或)坏死的肿瘤细胞核作为抗原,将131I标记的肿瘤细胞核人鼠嵌合单克隆抗体(131I-chTNT)与该抗原结合,导致肿瘤坏死,这是一种新型放射免疫治疗法。该方法为肺癌的治疗提供了又一新的方法,然而其治疗肺癌的完全缓解率低。MWA扩大了肿瘤坏死区而有效地增加了131I-chTNT治疗结合抗原的靶点,故MWA联合131I-chTNT治疗可望明显提高对肺癌的治疗效果。
Abstract:
Microwave ablation(MWA) has been considered as an advanced, minimally invasive technique in the treatment of lung cancer with a high local efficiency. MWA can inactivate tumor cells based on microwave heating mechanisms. It has a high local control rate of primary peripheral lung cancer and metastatic lung cancer result from percutaneous microwave antennas injection under ultrasound, CT and MRI guidance. However, for the lesions those are greater than 3.0 cm in diameter or abutting the hilars and the diffuse lesions there is less effective.131I labeled tumor necrosis therapy chimeric antibody (131I-chTNT), a novel radioimmunotherapy which uses cell of degeneration or necrotic tumor cell nuclear antigen as target provides a new therapeutic approach for lung cancer, but the complete response is low. MWA can induce a mass tumor necrosis under the action of microwave thermal effect which greatly increases the targeting area for 131I-chTNT radioimmunotherapy. Therefore, combination of MWA and 131I-chTNT will enhance the treatment efficacy of lung cancer.

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备注/Memo

备注/Memo:
收稿日期:2012-06-04。
基金项目:广州市属高校科研一般项目(10A241)
通讯作者:张金山(Email:zhangjsgdl37@163.com)
更新日期/Last Update: 1900-01-01