[1]冯彦林,王颖,张宁,等.鼻咽癌不同模式放疗后的PET/CT早期评估价值的研究[J].国际放射医学核医学杂志,2014,38(4):223-226,246.[doi:10.3760/cma.j.issn.1673-4114.2014.04.004]
　Feng Yanlin,Wang Ying,Zhang Ning,et al.Early evaluation value of PET/CT in nasopharyngeal carcinoma after different models of radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):223-226,246.[doi:10.3760/cma.j.issn.1673-4114.2014.04.004]
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鼻咽癌不同模式放疗后的PET/CT早期评估价值的研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第4期
页码:
223-226,246
栏目:
出版日期:
2014-07-25

文章信息/Info

Title:
Early evaluation value of PET/CT in nasopharyngeal carcinoma after different models of radiotherapy
作者:
冯彦林1;  王颖1;  张宁2;  冼伟均1;  温广华1;  张洋2;  陈露斯2
1. 佛山市第一人民医院核医学科, 528000;
2. 佛山市第一人民医院放疗科, 528000
Author(s):
Feng Yanlin1;  Wang Ying1;  Zhang Ning2;  Xian Weijun1;  Wen Guanghua1;  Zhang Yang2;  Chen Lusi2
Department of Nuclear Medicine, the First People’s Hospital of Foshan, Foshan 528000, China
关键词:
鼻咽肿瘤; 正电子发射断层显像术; 放射疗法; 适形; 放射疗法; 调强适形
Keywords:
Nasopharyngeal neoplasms; Positron emission tomography; Radiotherapy; conformal; Intensity modulation radiation therapy
DOI:
10.3760/cma.j.issn.1673-4114.2014.04.004
摘要:
目的 研究鼻咽癌在适形放疗(CRT)和调强放疗(IMRT)不同模式放疗后1周18F-FDG PET/CT显像早期评估的价值。方法 对CRT组21例及IMRT组19例患者放疗后1周进行PET/CT显像评估,分别进行目测分析及测量最大标准化摄取值(SUVmax),并与两年临床随访结果及病理活检结果进行对照。结果 CRT组患者2年临床随访无肿瘤残留,IMRT组17例患者活检结果无残留、2例活检结果为阳性;放疗前PET/CT显像CRT组与IMRT组的SUVmax分别为9.57±4.33、9.40±3.32,两组间差异无统计学意义(t=-0.43,P=0.132);放疗后CRT组与IMRT活检阴性组的SUVmax分别为2.38±0.34、3.10±0.55,两组间差异有统计学意义(t=-3.4,P=0.002)。CRT组目测诊断准确率为76.2%,目测假阳性率为23.8%;IMRT组目测诊断准确率为63.2%,目测假阳性率为36.8%。结论 放疗后1周作为18F-FDG PET/CT对鼻咽癌CRT后评估时间点是可行的;放疗后1周IMRT组的SUVmax较高,不是PET/CT的最佳评估时间点。
Abstract:
Objective To study the early evaluation value of 18F-FDG PET/CT imaging in nasopharyngeal carcinoma on the 7-day after different models of radiotherapy,including conformal radiotherapy (CRT)and intensity-modulated radiotherapy (IMRT).Methods PET/CT imaging was performed in 21 cases of CRT group and 19 cases of IMRT group on the 7-day after radiotherapy.The visual examination was performed and the maximum standardized uptake value (SUVmax)was measured,and the results were compared with the two years clinical follow-up and the result of pathological biopsy.Results Two years clinical follow-up of the CRT group confirmed there was no residual tumor.There was no residual tumor in 17 cases and 2 cases were positive of the IMRT group confirmed by biopsy.The SUVmax of the CRT group and the IMRT group were 9.57±4.33 and 9.40±3.32 respectively before radiotherapy without significant difference (t=-0.43,P=0.132).SUVmax of the CRT group and the negative patients confirmed by biopsy of the IMRT group were 2.38±0.34 and 3.1 ±0.55 respectively after radiotherapy with significant difference (t=-3.4,P=0.002).The accuracy rate and the false positive rate of visual examination of the CRT group were 76.2% and 23.8% respectively.The accuracy rate and the false positive rate of visual examination of the IMRT group were 63.2% and 36.8% respectively.Conclusions One week after nasopharyngeal carcinoma CRT is the feasible time-point for 18F-FDG PET/CT assessment.SUVmax of the IMRT group on 7-day after radiotherapy was higher than that in CRT group,so this time-point is not the best evaluation timepoint of the PET/CT.

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备注/Memo

备注/Memo:
收稿日期:2013-07-25。
基金项目:佛山市医学科技攻关项目(20111021010125)
通讯作者:冯彦林(Email:fylin@fsyyy.com)
更新日期/Last Update: 1900-01-01