[1]龙伟,吴红英,张晓东,等.血必净辐射防护作用机制的计算机模拟研究[J].国际放射医学核医学杂志,2013,37(6):329-332.[doi:10.3760/cma.j.issn.1673-4114.2013.06.001]
　LONG Wei,WU Hong-ying,ZHANG Xiao-dong,et al.Computational study for mechanisms of radiation protection effects of Xuebijing[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):329-332.[doi:10.3760/cma.j.issn.1673-4114.2013.06.001]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第6期
页码:
329-332
栏目:
论著
出版日期:
2013-11-25

文章信息/Info

Title:
Computational study for mechanisms of radiation protection effects of Xuebijing
作者:
龙伟;  吴红英;  张晓东;  周则卫;  沈秀;  王浩;  李德冠;  孟爱民;  刘培勋
中国医学科学院放射医学研究所, 天津市分子核医学重点实验室, 天津 300192
Author(s):
LONG Wei;  WU Hong-ying;  ZHANG Xiao-dong;  ZHOU Ze-wei;  SHEN Xiu;  WANG Hao;  LI De-guan;  MENG Ai-min;  LIU Pei-xun
Tianjin Key Laboratoty of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese A cademy of Medical Sciences, Tianjin 300192, China
关键词:
辐射防护; 分子作用机制; 计算机模拟; 血必净; 分子对接
Keywords:
Radiation protection; Molecular mechanisms of action; Computer simulation; Xuebijing; Molecular docking
DOI:
10.3760/cma.j.issn.1673-4114.2013.06.001
摘要:
目的 研究中药复方血必净辐射防护作用的可能机制.方法 通过计算机模拟技术——分子对接的方法将血必净化学成分分子与凝血酶、纤溶酶原激活物抑制物1、血栓素A2受体、凝血因子Ⅸa等4个重要凝血靶点进行对接,分析对接结果,评价作用效应.结果 血必净对凝血酶、纤溶酶原激活物抑制物1、血栓素A2受体和凝血因子Ⅸa等凝血靶点均具有一定的拮抗作用,其中对凝血酶的作用最为显著.结论 血必净辐射防护作用的产生很可能与凝血靶点的拮抗相关.
Abstract:
Objective To explore the related mechanisms of Xuebijing anti-radiation effects.Methods The chemical molecules in Xuebijing were docked into four blood coagulation targets:thrombin,plasminogen activator inhibitor type 1,thromboxane A2 receptor and blood coagulation factor Ⅸa by molecular docking technology respectively,and then the docking results were analyzed and the effect of the mechanisms was evaluated.Results The chemical molecules in Xuebijing had interactions with all four blood coagulation targets,especially for thrombin.Conclusion The related mechanism of Xuebijing anti-radiation effect is probably resulted from the antagonism effect towards blood coagulation targets.

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备注/Memo

备注/Memo:
收稿日期:2012-09-24。
基金项目:国家自然科学基金(81202153,81072237,81102873);教育部博士点新教师基金(20121106120042);中国医学科学院放射医学研究所学科发展基金(SF1227,SZ1337);天津市自然科学基金(12JCQNJC09100)
通讯作者:刘培勋,Email:liupeixun@irm-carns.ac.cn
更新日期/Last Update: 1900-01-01