[1]蔡莉,高硕.PET在精神分裂症中的研究进展[J].国际放射医学核医学杂志,2011,35(2):69-72.[doi:10.3760/cma.j.issn.1673-4114.2011.02.002]
 CAI Li,GAO Shuo.Progress of PET imaging in Schizophrenia[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(2):69-72.[doi:10.3760/cma.j.issn.1673-4114.2011.02.002]
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PET在精神分裂症中的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第2期
页码:
69-72
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Progress of PET imaging in Schizophrenia
作者:
蔡莉 高硕
300052 天津, 天津医科大学总医院PET-CT中心
Author(s):
CAI Li GAO Shuo
PET/CT Center, General Hospital of Tianjin Medical University, Tianjin 300052, China
关键词:
正电子发射断层显像术受体多巴胺受体血清素精神分裂症认知障碍
Keywords:
Positron-emission tomographyReceptorsdopamineReceptorsserotoninSchizophreniaCognition disorders
DOI:
10.3760/cma.j.issn.1673-4114.2011.02.002
摘要:
PET是一种可以用于评估大脑代谢活性、血流及确定人脑中重要的神经递质分布的功能神经影像工具。与传统影像技术相比,PET能够借助不同的示踪剂定性、定量地分析大脑葡萄糖代谢、血流、多巴胺及5-羟色胺神经递质和受体的分布及活性改变,因此广泛用于精神分裂症的神经生化及病理生理学机制的研究。该文通过不同的放射性示踪剂,简要综述PET在精神分裂症患者中的大脑多巴胺能神经递质及受体、5-羟色胺受体的分布、认知功能障碍等方面的研究进展。
Abstract:
PET is an important functional neuroimaging technique that can be used to assessment of cerebral metabolic activity and blood flow and identifies the distribution of important neurotransmitters in the human brain. Compared with other conventional imaging techniques, PET enables regional cerebral glucose metabolism, blood flow, dopaminergic and serotonergic receptor function to be assessed qualitatively and quantitatively. In recent years, PET increasingly being used greatly to advance our understanding of the neurobiology and pathophysiology of schizophrenia. This review focuses on the use of PET tracers in identifying regional brain abnormalities and regions associated with cognitive functioning in schizophrenia.

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备注/Memo

备注/Memo:
收稿日期:2011-01-08。
通讯作者:高硕,Email:dr_shuogao@hatmail.com
更新日期/Last Update: 1900-01-01