[1]邱春,管一晖.5-羟色胺受体显像剂在神经系统疾病及脑功能研究中的应用[J].国际放射医学核医学杂志,2011,35(2):73-80,127.[doi:10.3760/cma.j.issn.1673-4114.2011.02.003]
 QIU Chun,GUAN Yi-hui.Application of 5-hydroxytryptamine receptor imaging for study of neuropsychiatric disorders and brain functions[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(2):73-80,127.[doi:10.3760/cma.j.issn.1673-4114.2011.02.003]
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5-羟色胺受体显像剂在神经系统疾病及脑功能研究中的应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第2期
页码:
73-80,127
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Application of 5-hydroxytryptamine receptor imaging for study of neuropsychiatric disorders and brain functions
作者:
邱春 管一晖
200032 上海, 上海华山医院PET中心
Author(s):
QIU Chun GUAN Yi-hui
PET Center, Huashan Hospital, Fudan University, Shanghai 200032, China
关键词:
受体血清素中枢神经系统放射性核素显像受体显像
Keywords:
ReceptorsserotoninCentral nervous systemRadionuclide imagingReceptor imaging
DOI:
10.3760/cma.j.issn.1673-4114.2011.02.003
摘要:
5-羟色胺(5-HT)受体广泛分布于中枢神经系统,参与精神与情绪、自主神经系统功能、睡眠与觉醒、内分泌活动等的调节,与疼痛、抑郁症、癫癎等诸多疾病存在广泛而直接的联系。随着5-HT受体核素显像剂的不断开发,利用SPECT、PET对中枢神经系统进行无创性的5-HT受体显像已经广泛开展,并为临床诊断和治疗上述疾病提供了独一无二的活体功能信息;在药物研发和疗效评估方面也具有无可替代的价值;此外,此方法还为脑功能的研究提供了全新的手段。该文主要就中枢神经系统5-HT受体的生物学特性、放射性核素显像剂及其临床研究进展进行阐述。
Abstract:
In the central nervous system, the widely distributed 5-hydroxytryptamine(5-HT)receptors are involved in regulating a large number of psychological and physiological functions, including mood,sleep, endocrine and autonomic nervous system. Abnormal 5-HT transmission has been implicated in a variety of neuropsychiatric disorders, such as pain, depression and epilepsy. With the development of radioligands, non-invasive nuclear imaging technique with exquisite sensitivity and specificity has been applied for delineation of neurotransmitter function in vivo. It does great benefit for researches of these diseases and development of drugs. This review provided an overview of 5-HT receptors radioligands and recent findings.

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备注/Memo

备注/Memo:
收稿日期:2011-01-20。
通讯作者:管一晖,Email:aimarandkimi@hotmail.com
更新日期/Last Update: 1900-01-01