[1]王亚飞,孟庆勇.放射性核素反义技术在肿瘤治疗中的研究[J].国际放射医学核医学杂志,2006,30(3):142-144.
 WANG Ya-fei,MENG Qing-yong.Application of the radionuclide antisense technique in the treatment of tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):142-144.
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放射性核素反义技术在肿瘤治疗中的研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第3期
页码:
142-144
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Application of the radionuclide antisense technique in the treatment of tumors
作者:
王亚飞 孟庆勇
524023 湛江, 广东医学院分析中心
Author(s):
WANG Ya-fei MENG Qing-yong
Analytical Center in Medical College of Guangdong, Guangdong Zhanjiang 524023, China
关键词:
放射性同位素寡核苷酸类反义放射肿瘤学
Keywords:
RadioisotopesOligonucleotdesantisenseRadiation oncology
分类号:
R730.55
摘要:
放射性核素反义治疗是放射性核素产生辐射生物效应杀伤病变细胞与反义寡核苷酸链阻断基因表达相结合而达到治疗疾病的目的,具有特异性强、靶向性高和损伤性小等优点,为肿瘤的治疗提供了新方法。
Abstract:
Radionuclide antisense technique, which combined radiation biological effect with antisense therapy, treats polygenic diseases, especially tumors. Antisense oligonucleotide labeled with radionuclide can target abnormal gene specially, thus radiation biological effect takes place in the abnormal part of cells, and does not damage normal part of cells. This will be a new way in the treatment of diseases.

参考文献/References:

1 Kassis AI, Adelstein SJ, Mariani G. Radiolabeled nucleoside analog cancer diagnosis and therapy. J Nucl Med, 1996, 40(3):301-319.
2 孙晗笑, 陆大祥, 刘飞鹏, 等.转基因技术理论与应用.郑州:河南医科大学出版社,2000.346-364.
3 Sedelnikova OA, Panyutin IG, Thierry AR, et al. Radiotoxicity of iodine-125-labeled oligodeoxyribonucleotides in mammalin cells. J Nucl Med, 1998, 39(8):1412-1418.
4 Panyutin IG, Neumann RD. Sequence-specific DNA breaks produced by triplex-directde decay of iodine-125. Acta Oncol,1996, 35(7):817-823.
5 Cammilleri S, Perdereau B, Brixy F, et al. Imaging and biodistribution of 125I tyramine oligonucleotide in nude mice bearing human breast tumor. Preliminary report. Bull Cancer Paris, 1996, 83(1):23-26.
6 刘生, 刘长征, 梁碧玲, 等.碘标记反义寡核苷酸的研究及其稳定性与生物分布的评价.核技术,2004,27(5):365-369.
7 Spitzweg C, Scholz IV, Bergert ER, et al. Retinoic acid induced stimulation of sodium iodide symporter expression and cytotoxicity of radioiodine in prostate cancer cells. Endaocrinology, 2003, 144(8):3423-3432.
8 Ou X, Tan T, He L, et al. Antitumor effects of radioiodinated antisense oligonuclide mediated by VIP receptor. Cancer Gene Ther, 2005, 12(3):313-320.

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备注/Memo

备注/Memo:
收稿日期:2005-06-08。
通讯作者:孟庆勇(E-mail:mqy1586@sina.com)
更新日期/Last Update: 1900-01-01