[1]黄建敏,曲雁,潘莉萍.恶性骨肿瘤多药耐药的99Tcm-MIBI体层显像研究[J].国际放射医学核医学杂志,2005,29(4):169-170.
　HUANG Jian-min,QU Yan,PAN Li-ping.Research of 99Tcm-MIBI SPECT imaging for assessment of multidrug resistance in Bone tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):169-170.
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恶性骨肿瘤多药耐药的99Tcm-MIBI体层显像研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第4期
页码:
169-170
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Research of 99Tcm-MIBI SPECT imaging for assessment of multidrug resistance in Bone tumor
作者:
黄建敏;  曲雁;  潘莉萍
050051 石家庄, 河北医科大学第三医院核医学科
Author(s):
HUANG Jian-min;  QU Yan;  PAN Li-ping
Department of Nuclear Medicine, the Third Hospital, Hebei Medical University, Shijiazhuang 050051, China
关键词:
骨肿瘤; 单光子; 发射型计算机; 体层摄影术; 多药耐药; 99Tcm-甲氧基异丁基异腈
Keywords:
bone tumor; single photon emission computed tomography; multidrug resistance; 99Tcm-sestamibi
分类号:
R817.4
摘要:
大多数肿瘤都有多药耐药-1(MDR-1)基因的过度表达,其表达产物P-糖蛋白(P-gp)在肿瘤的耐药机制中起着关键作用,对P-gp表达的预测在化疗中至关重要,99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)转运分析可作为探测低水平的P-gp表达和定量评价调节转运的敏感指标,指导应用调节剂改善化疗效果。
Abstract:
There has a overexpression ofmultidrug resistance (MDR) gene in most tumor. It is very important that it’s expression product P-glycoprotein(P-gp)in multidrug resistance machine of tumor. The anticipation for P-gp expression is significance for chemotherapy. The conveying analysis of 99Tcm-sestamibi (99Tcm-MIBI) is a sensitiveness index for low-level P-gp expression.

参考文献/References:

1 周际昌.实用肿瘤内科学[M].北京:人民卫生出版社,2003.85.
2 Baldini N, Scotland K, Scrra M, et al. Adria mycin binding assay;avaluable chemosensitivety test in human ostesarcoma[J]. J Cancer Res Clin Oncol, 1992, 119(1):121-126.
3 Burak Z, Ersoy O, Moretti J, et al. The role of 99mTc-MIBI scintigraphy in the assessment of MDR1 overexpression in patients with musculoskeletal sarcomas:comparison with therapy response[J]. Eur J Nucl Med, 2001, 28(9):1341-1350.
4 Junichi T, Hisashi S, Naohiro A, et al. Assessment of P-glycoprotein in patients with malignant bone and soft-tissue tumors using technetium-99m-MIBI scintigraphy[J]. J Nucl Med, 1998, 39(10):1179-1184.
5 Burak Z, Moretti JL, Ersoy O, et al.99mTc-MIBI imaging as a predictor of therapy response in osteosarcoma compared with multidrug resistance-associated protein and P-glycoprotein exprenssion[J]. J Nucl Med, 2003, 44(9):1394-1401.

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备注/Memo

备注/Memo:
收稿日期:2004-12-20。
更新日期/Last Update: 1900-01-01