[1]王祯祯,高光凯.高压氧对迟发性放射损伤的作用[J].国际放射医学核医学杂志,2017,41(1):63-67.[doi:10.3760/cma.j.issn.1673-4114.2017.01.012]
 Wang Zhenzhen,Gao Guangkai.Hyperbaric oxygen therapy for delayed radiation injuries[J].International Journal of Radiation Medicine and Nuclear Medicine,2017,41(1):63-67.[doi:10.3760/cma.j.issn.1673-4114.2017.01.012]
点击复制

高压氧对迟发性放射损伤的作用(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
41
期数:
2017年第1期
页码:
63-67
栏目:
综述
出版日期:
2017-01-25

文章信息/Info

Title:
Hyperbaric oxygen therapy for delayed radiation injuries
作者:
王祯祯 高光凯
266071 青岛, 中国人民解放军第四〇一医院高压氧科
Author(s):
Wang Zhenzhen Gao Guangkai
Department of Hyperbaric Medicine, No. 401 Hospital of People’s Liberation Army, Qingdao 266071, China
关键词:
高压氧辐射损伤放射疗法
Keywords:
Hyperbaric oxygenationRadiation injuriesRadiotherapy
DOI:
10.3760/cma.j.issn.1673-4114.2017.01.012
摘要:
放射疗法是一种对肿瘤和周围正常组织均有显著作用的物理疗法,在放疗的同时,不可避免地会损伤正常组织导致放射损伤,特别是迟发性放射损伤,这将严重影响患者的生存质量。随着时间的推移迟发性放射损伤会发展得更加严重,甚至致死,因此限制了临床治疗时的放射剂量,目前这一问题并未得到解决。笔者主要就高压氧治疗对迟发性放射损伤的影响作一综述。
Abstract:
Radiation therapy is a potent physical entity with dramatic effects in both malignant and surrounding normal tissues. Untoward reactions to radiation therapy in normal tissues are most frequently classified as either acute or delayed reactions. They are often progressive and serious and occasionally even lethal. These injuries effectively limit the clinical dose of radiation. This article mainly provides an overview of the use of hyperbaric oxygen therapy for delayed radiation injuries.

参考文献/References:

[1] 曹婉婷, 李浣洋, 陈雪英, 等.正常组织在放射治疗中并发的迟发性损伤[J].国际放射医学核医学杂志, 2015, 39(3):260-263.DOI:10.3760/cma.j.issn.1673-4114.2015.03.016.Cao WT, Li HY, Chen XY, et al.Late effects of radiotherapy on normal tissue[J].Int J Radiat Med Nucl Med, 2015, 39(3):260-263.
[2] Nieder C, Andratschke NH, Grosu AL.Normal tissue studies in radiation oncology:A systematic review of highly cited articles and citation patterns[J].Oncol Lett, 2014, 8(3):972-976.DOI:10.3892/ol.2014.2252.
[3] Rubin P.The franz buschke lecture:late effects of chemotherapy and radiation therapy:a new hypothesis[J].Int J Radiat Oncol Biol Phys, 1984, 10(1):5-34.
[4] Fleckenstein K, Gauter-Fleckenstein B, Jackson IL, et al.Using biological markers to predict risk of radiation injury[J].Semin Radiat Oncol, 2007, 17(2):89-98.DOI:10.1016/j.semradonc.2006.11.004.
[5] Marx RE.Radiation injury to tissue[M]//Kindwall EP.Hyperbaric Medicine Practice.2nd ed.Flagstaff:Best Publishing, 1999:665-723.
[6] Goldstein J, Gallagher A, Bauer M, et al.Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxide[J].Stem Cells, 2006, 24(10):2309-2318.DOI:10.1634/stemcells.2006-0010.
[7] Gallagher KA, Liu ZJ, Xiao M, et al.Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha[J].J Clin Invest, 2007, 117(5):1249-1259.DOI:10.1172/JCI29710.
[8] Feldmeier JJ, Hampson NB.A systematic review of the literature reporting the application of hyperbaric oxygen prevention and treatment of delayed radiation injuries:an evidence based approach[J].Undersea Hyperb Med, 2002, 29(1):4-30.
[9] Gomez DR, Estilo CL, Wolden SL, et al.Correlation of osteoradionecrosis and dental events with dosimetric parameters in intensity-modulated radiation therapy for head-and-neck cancer[J/OL].Int J Radiat Oncol Biol Phys, 2011, 81(4):e207-e213[2016-08-29].http://www.sciencedirect.com/science/article/pii/S0360301611002100.DOI:10.1016/j.ijrobp.2011.02.003.
[10] Hampson NB, Holm JR, Wreford-Brown CE, et al.Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen for chronic radiation tissue injury[J].Cancer, 2012, 118(15):3860-3868.DOI:10.1002/cncr.26637.
[11] 余盛忠.探讨高压氧加手术治疗放射性颌骨坏死的临床分析[J].中外医疗, 2012, 31(6):97.DOI:10.3969/j.issn.1674-0742.2012.06.073.Yu SZ.To investigate the clinical effect of hyperbaric oxygen therapy in the treatment of the patients with radioactive jaw necrosis[J].China Foreign Med Treat, 2012, 31(6):97.
[12] Marx RE, Ehler WJ, Tayapongsak P, et al.Relationship of oxygen dose to angiogenesis induction in irradiated tissue[J].Am J Surg, 1990, 160(5):519-524.
[13] Marx RE, Johnson RP.Studies in the radiobiology of osteoradionecrosis and their clinical significance[J].Oral Surg Oral Med Oral Pathol, 1987, 64(4):379-390.
[14] Ni XC, Sun W, Sun SP, et al.Therapeutic potential of adipose stem cells in tissue repair of irradiated skeletal muscle in a rabbit model[J].Cell Reprogram, 2014, 16(2):140-150.DOI:10.1089/cell.2013.0056.
[15] Mitsimponas KT, Moebius P, Amann K, et al.Osteo-radio-necrosis (ORN) and bisphosphonate-related osteonecrosis of the Jaws (BRONJ):the histopathological differences under the clinical similarities[J].Int J Clin Exp Pathol, 2014, 7(2):496-508.
[16] 丰岩清, 张为西, 郑民缨, 等.抗分枝杆菌治疗逆转鼻咽癌放疗后迟发性放射性脑病的初步研究[J/OL].中华脑科疾病与康复杂志:电子版, 2015, 5(2):95-102[2016-08-29].http://www.cjbdr.net/upload/pdf/201504/20150428044904273.pdf.DOI:10.3877/cma.j.issn.2095-123X.2015.02.006.Feng YQ, Zhang WX, Zheng MY, et al.Anti-mycobacterium treatment reverses radiation-induced delayed brain injuries of nasopharyngeal carcinoma:a pilot study[J/OL].Chin J Brain Dis Rehabil(Electronic Edition), 2015, 5(2):95-102[2016-08-29].http://www.cjbdr.net/upload/pdf/201504/20150428044904273.pdf.
[17] 王行富, 张声, 叶郁红, 等.脑肿瘤放射性治疗后迟发型脑损伤的临床病理学特征[J].中华病理学杂志, 2012, 41(4):224-228.DOI:10.3760/cma.j.issn.0529-5807.2012.04.003.Wang XF, Zhang S, Ye YH, et al.Clinicopathologic features of delayed radiation-induced brain injury after radiotherapy for brain tumor[J].Chin J Pathol, 2012, 41(4):224-228.
[18] 李璟, 孟君, 姜炜.高压氧治疗对颅内转移瘤放射治疗后患者放射性神经损伤的预防作用[J].中华物理医学与康复杂志, 2013, 35(11):863-864.DOI:10.3760/cma.j.issn.0254-1424.2013.11.008.Li J, Meng J, Jiang W.The preventive effect of hyperbaric oxygen therapy on radiation injury in patients with intracranial metastases after radiation therapy[J].Chin J Phys Med Rehabil, 2013, 35(11):863-864.
[19] 赵刚.高压氧联合放疗治疗脑瘤术后患者的临床疗效[J].中国药物经济学, 2016, (1):135-136.DOI:10.12010/j.issn.1673-5846.2016.01.070.Zhao G.The clinical efficacy of hyperbaric oxygen combined with radiotherapy for brain tumor patients[J].China J Pharm Econ, 2016, (1):135-136.
[20] 张惠珺.术后高压氧加放疗治疗脑瘤患者的临床疗效观察[J].现代诊断与治疗, 2016, 27(1):105-106.Zhang HJ.The postoperative clinical efficacy of hyperbaric oxygen combined with radiotherapy for brain tumor patients[J].Mod Diagn Treat, 2016, 27(1):105-106.
[21] 张红心.高压氧联合放疗和单纯放疗对脑瘤术后治疗的临床效果比较[J].当代医学, 2013, 19(33):101-102.DOI:10.3969/j.issn.1009-4393.2013.33.077.Zhang HX.The clinical effect comparison of hyperbaric oxygen combined with radiotherapy and radiotherapy in the postoperative treatment of brain tumor[J].Contemp Med, 2013, 19(33):101-102.
[22] 蔡政云.脑瘤术后高压氧加放疗治疗的临床观察[J].中国医师杂志, 2011, 13(6):797-799.DOI:10.3760/cma.j.issn.1008-1372.2011.06.023.Cai ZY.The clinical observation of brain tumor after hyperbaric oxygen therapy combined with radiotherapy[J].J Chin Phys, 2011, 13(6):797-799.
[23] 匡静, 冯婷, 郑佳.手术后高压氧加放疗治疗脑瘤的疗效[J].中国肿瘤临床与康复, 2015, 22(3):323-325.DOI:10.13455/j.cnki.cjcor.2015.03.22.Kuan J, Feng T, Zhen J.Efficacy of hyperbaric oxygen plus postoperative radiotherapy in the treatment of brain tumor[J].Chin J Clin Oncol Rehabil, 2015, 22(3):323-325.
[24] Gesell LB, Warnick RE, Breneman J, et al.Effectiveness of hyperbaric oxygen therapy for the treatment of soft tissue radionecrosis of the brain[C/OL]//Undersea and Hyperbaric Medical Society Annual Meetings, 2002[2016-08-29].http://archive.rubicon-foundation.org/xmlui/handle/123456789/943.
[25] 崔志刚, 何平, 马惠珍, 等.出血性放射性膀胱炎的临床疗效观察[J].现代泌尿外科杂志, 2012, 17(2):188-190.DOI:10.3969/j.issn.1009-8291.2012.02.029.Cui ZG, He P, Ma HZ, et al.Efficacy of different treatments of hemorrhagic radiation cystitis[J].J Mod Urol, 2012, 17(2):188-190.
[26] Chong KT, Hampson NB, Corman JM.Early hyperbaric oxygen therapy improves outcome for radiation-induced hemorrhagic cystitis[J].Urology, 2005, 65(4):649-653.DOI:10.1016/j.urology.2004.10.050.
[27] 郑成刚, 刘青乐.高压氧在肿瘤放疗中的应用[C]//中华医学会第十九次全国高压氧医学学术会议论文集, 重庆, 2010.Zheng CG, Liu QL.Application of hyperbaric oxygen in tumor radiotherapy[C]//Proceedings of the 19th National Symposium of Hyperbaric Oxygen Medicine, Chongqing, 2010.
[28] Neuman TS, Thom SR.Physiology and Medicine of Hyperbaric Oxygen Therapy[M].USA:Saunders, 2008:252-253.
[29] Voûte PA, van der Kleij AJ, De Kraker J, et al.Clinical experience with radiation enhancement by hyperbaric oxygen in children with recurrent neuroblastoma stage IV[J].Eur J Cancer, 1995, 31A(4):596-600.
[30] 孟君.高压氧辅助治疗放射性神经损伤相关问题的探讨[J].国际放射医学核医学杂志, 2013, 37(6):381-384.DOI:10.3760/cma.j.issn.1673-4114.2013.06.014.Meng J.Discussion about hyperbaric oxygen therapy in adjuvant treatment of radioactive nerve injury[J].Int J Radiat Med Nucl Med, 2013, 37(6):381-384.
[31] Davis AM, Dische S, Gerber L, et al.Measuring postirradiation subcutaneous soft-tissue fibrosis:state-of-the-art and future directions[J].Semin Radiat Oncol, 2003, 13(3):203-213.DOI:10.1016/S1053-4296(03)00022-5.

相似文献/References:

[1]包明月,刘玉龙.应用间充质干细胞治疗急性辐射损伤的研究现状与进展[J].国际放射医学核医学杂志,2016,40(1):65.[doi:10.3760/cma.j.issn.1673-4114.2016.01.013]
 Bao Mingyue,Liu Yulong.Recent advances in the application of mesenchymal stem cells for treatment of acute radiation injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):65.[doi:10.3760/cma.j.issn.1673-4114.2016.01.013]
[2]贺欣,储小飞,罗丹,等.穿心莲药物对辐射损伤效应影响的初步研究[J].国际放射医学核医学杂志,2015,39(5):375.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 005]
 he xin,chu xiaofei,luo dan,et al.exploration of andrographolide effects on radiation injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):375.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 005]
[3]路璐,张俊伶,李德冠,等.6 gy 137cs γ射线照射对小鼠造血功能损伤的动态观察研究[J].国际放射医学核医学杂志,2015,39(5):393.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 009]
 lu lu*,zhang junling,li deguan,et al.effects of 6 gy 137cs γ-irradiattion on the hematopoietic system of mice[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):393.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 009]
[4]刘惠惠,李险峰.放射性心脏损伤诊断和防治的临床研究进展[J].国际放射医学核医学杂志,2016,40(5):374.[doi:10.3760/cma.j.issn.1673-4114.2016.05.008]
 Liu Huihui,Li Xianfeng.Clinical research progress in diagnosis,prevention and treatment of radiation-induced heart disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):374.[doi:10.3760/cma.j.issn.1673-4114.2016.05.008]
[5]张倩如,李海涛,田红旗.小分子辐射防护药物的研究进展[J].国际放射医学核医学杂志,2016,40(5):394.[doi:10.3760/cma.j.issn.1673-4114.2016.05.012]
 Zhang Qianru,Li Haitao,Tian Hongqi.Small molecule compounds against radiation:research advances[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):394.[doi:10.3760/cma.j.issn.1673-4114.2016.05.012]
[6]王浩,沈秀,靳瑾,等.“四物汤”对辐射危害的辅助保护作用研究[J].国际放射医学核医学杂志,2015,39(2):121.[doi:10.3760/cma.j.issn.1673-4114.2015.02.004]
 Wang Hao,Shen Xiu,Jin Jin,et al.Protective activity of Siwu Decoction against radiation hazards[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):121.[doi:10.3760/cma.j.issn.1673-4114.2015.02.004]
[7]曹婉婷,李浣洋,陈雪英,等.正常组织在放射治疗中并发的迟发性损伤[J].国际放射医学核医学杂志,2015,39(3):260.[doi:10.3760/cma.j.issn.1673-4114.2015.03.016]
 Cao Wanting,Li Huanyang,Chen Xueying,et al.Late effects of radiotherapy on normal tissue[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):260.[doi:10.3760/cma.j.issn.1673-4114.2015.03.016]
[8]陈雪梅,周树云,范源,等.表没食子儿茶素没食子酸酯对131I辐射损伤所致甲减大鼠模型抗氧化体系的保护作用[J].国际放射医学核医学杂志,2015,39(4):311.[doi:10.3760/cma.j.issn.1673-4114.2015.04.009]
 Chen Xuemei,Zhou Shuyun,Fan Yuan,et al.Protection of antioxidant system of EGCG on the thyroid in rat model from 131I radiation damage[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):311.[doi:10.3760/cma.j.issn.1673-4114.2015.04.009]
[9]李德冠,路璐,吴红英,等.G-CSF联合SB203580对4Gy照射小鼠免疫系统的作用[J].国际放射医学核医学杂志,2014,38(4):216.[doi:10.3760/cma.j.issn.1673-4114.2014.04.002]
 Li Deguan,Lu Lu,Wu Hongying,et al.The effects of G-CSF combined with SB203580 on the immune system of mice received 4 Gy total body irradiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(1):216.[doi:10.3760/cma.j.issn.1673-4114.2014.04.002]
[10]张洪明,李险峰.放射性心脏损伤动物模型的研究进展[J].国际放射医学核医学杂志,2014,38(6):412.[doi:10.3760/cma.j.issn.1673-4114.2014.06.015]
 Zhang Hong-ming,Li Xian-feng.Progress in animal model of radiation-induced heart disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(1):412.[doi:10.3760/cma.j.issn.1673-4114.2014.06.015]

备注/Memo

备注/Memo:
收稿日期:2016-08-29。
通讯作者:高光凯,Email:gaogk@sohu.com
更新日期/Last Update: 1900-01-01