[1]贾立立,孟粹达,刘晓冬,等.头颈部肿瘤放疗中转化医学相关机制的研究进展[J].国际放射医学核医学杂志,2015,39(3):247-251.[doi:10.3760/cma.j.issn.1673-4114.2015.03.013]
 Jia Lili,Meng Cuida,Liu Xiaodong,et al.Development in translational medicine-related mechanisms of radiotherapy for head and neck cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):247-251.[doi:10.3760/cma.j.issn.1673-4114.2015.03.013]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第3期
页码:
247-251
栏目:
出版日期:
2015-05-25

文章信息/Info

Title:
Development in translational medicine-related mechanisms of radiotherapy for head and neck cancer
作者:
贾立立1 孟粹达2 刘晓冬1 马淑梅1
1. 吉林大学公共卫生学院放射生物学教研室, 卫生部放射生物学重点实验室, 长春, 130021;
2. 吉林大学中日联谊医院耳鼻咽喉-头颈外科, 长春, 130033
Author(s):
Jia Lili1 Meng Cuida2 Liu Xiaodong1 Ma Shumei1
Key Laboratory of Radiobiology(Ministry of Health), School of Public Health, Jilin University, Changchun 130021, China
关键词:
头颈部肿瘤肿瘤鳞状细胞放射疗法转化医学
Keywords:
Head and neck neoplasmsNeoplasms squamous cellRadiotherapyTranslational medicine
DOI:
10.3760/cma.j.issn.1673-4114.2015.03.013
摘要:
头颈部肿瘤是目前世界上最常见的肿瘤之一,超过90%的头颈部肿瘤为鳞状细胞癌。放疗在头颈部肿瘤的治疗中显得尤为重要,目前国内治疗早期肿瘤可以单纯放疗为主,晚期肿瘤则选择综合性治疗。转化医学是近些年来新的研究重点,将科研过程及其成果与临床紧密结合,尤其体现在通过检测患者肿瘤组织中的基因突变靶点及基因单核苷酸多态性分型、mRNA基因定量表达,为临床提供靶向及个体化放疗的依据,能显著提高治疗的有效率。
Abstract:
Head and neck cancer is currently one of the most common tumors worldwide.More than 90% of head and neck tumors are squamous cell carcinoma.Radiotherapy is particularly important in the treatment of head and neck cancer.Current domestic treatment is sole radiotherapy for early tumors,but comprehensive treatment is administered for late tumors.Translational medicine,which closely connects results from studies and clinical medicine,has emerged as a new research focus in recent years.This method is expected to provide basis for target and individual radiotherapy through the detection of target gene mutations,gene single nucleotide polymorphism classification,and mRNA gene expression in tumor tissues of patients.Thus,this method can be used to evidently improve the efficiency of clinical treatment of tumors.

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备注/Memo

备注/Memo:
收稿日期:2014-11-17。
基金项目:国家自然科学基金(31370837);吉林大学基本科研业务费(项目编号:201103082)
通讯作者:马淑梅,Email:shmm2001@126.com
更新日期/Last Update: 1900-01-01