[1]田月丽,兰晓莉,张永学.18F-FDG PET/CT在鼻咽癌综合治疗后患者随访及预后评估中的价值[J].国际放射医学核医学杂志,2013,37(6):359-363,377.[doi:10.3760/cma.j.issn.1673-4114.2013.06.009]
　TIAN Yue-li,LAN Xiao-li,ZHANG Yong-xue.Prognostic value of 18F-FDG PET/CT for nasopharyngeal carcinoma patients follow-up after comprehensive therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):359-363,377.[doi:10.3760/cma.j.issn.1673-4114.2013.06.009]
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18F-FDG PET/CT在鼻咽癌综合治疗后患者随访及预后评估中的价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第6期
页码:
359-363,377
栏目:
综述
出版日期:
2013-11-25

文章信息/Info

Title:
Prognostic value of 18F-FDG PET/CT for nasopharyngeal carcinoma patients follow-up after comprehensive therapy
作者:
田月丽;  兰晓莉;  张永学
华中科技大学同济医学院附属协和医院核医学科, 分子影像湖北省重点实验室, 武汉 430022
Author(s):
TIAN Yue-li;  LAN Xiao-li;  ZHANG Yong-xue
Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China
关键词:
鼻咽肿瘤; 正电子发射断层显像术; 体层摄影术; X线计算机; 氟脱氧葡萄糖F18
Keywords:
Nasopharyngeal naoplasms; Position emission-tomography; Tomography; X-ray computed; Fluorodeoxyglucose F18
DOI:
10.3760/cma.j.issn.1673-4114.2013.06.009
摘要:
鼻咽癌是一类发病率较高、早期发现困难、误诊误治率较高的头颈部恶性肿瘤.多数鼻咽癌患者对放疗敏感,但仍有部分患者出现残留、复发或转移.PET/CT作为现代医学影像重要组成部分之一,将PET的功能显像与CT的解剖成像有机结合,不仅能有效显示肿瘤的增生、代谢、乏氧及细胞的凋亡状态,而且能精确显示肿瘤与其周围脏器组织的解剖结构,在鼻咽癌患者的临床诊断、分期、治疗及预后评估等方面具有重要价值.该文重点就PET/CT对鼻咽癌综合治疗后患者局部残留、复发或转移的诊断价值及预后评估效能进行综述.
Abstract:
Nasopharyngeal carcinoma (NPC),which has high morbidity,difficult diagnosis,and poor treatment results,is a type of malignant tumor in head and neck cancer.The mainstay treatment for nasopharyngeal carcinoma has been radiotherapy as NPC is sensitive to radiotherapy.However,there is a significant rate of local failures and distant metastases.PET/CT,an important imaging modality in modem medicine,combines the functional imaging of PET and the anatomic imaging of CT to efficiently image tumor proliferation,metabolism,hypoxia and cell apoptosis.It can also precisely image the anatomic structure of tumors and their adjacent organs or tissues.PET/CT was found to be particularly helpful for guiding diagnosis and therapy,the staging and grading of tumors,monitoring therapy and in evaluating the prognosis of patients with nasopharyngeal carcinoma.

参考文献/References:

[1] 黄盛才.PET/CT在鼻咽癌中的应用价值研究进展.广西医学, 2011,33(2):224-227.
[2] 何锦添.鼻咽癌66例误诊临床分析.广州医学院学报,2002, 30(2):88-89.
[3] Hong RL, Ting LL, Ko JY, et al. Induction chemotherapy with mitomycin, epirubicin, cisplatin, fluorouracil, and leucovorin followed by radiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma. J Clin Oncol, 2001, 19(23):4305-4313.
[4] 刘丽娟,吴金陵,修新胜,等.PET/CT显像在鼻咽癌中的应用, 中华现代影像学杂志,2006, 3(5):398-400.
[5] Liu T, Xu W, Yan WL, et al. FDG-PET, CT, MRI for diagnosis of local residual or recurrent nasopharyngeal carcinoma, which one is the best? A systematic review. Radiother Oncol, 2007, 85(3):327-335.
[6] King AD, Ma BB, Yan YY, et al. The impact of 18F-FDG PET/CT on assessment of nasopharyngeal carcinoma at diagnosis. Br J Radiol, 2008,81(964):291-298.
[7] 肖勇,李奕钊,郭晓君,等.PET/CT显像在判断鼻咽癌放疗后病灶残留或复发中的价值.广东医学,2007, 28(7):1140-1141.
[8] Gordin A, Golz A, Daitzchman M, et al. Fluorine-18 fluo-rodeoxyglucose positron emission tomography/computed tomography imaging in patients with carcinoma of the nasopharynx:diagnostic accuracy and impact on clinical management. Int J Radiat Oncol Biol Phys, 2007, 68(2):370-376.
[9] 申超,刘春雨,姚树展.18F-FDG PET-CT显像在鼻咽癌治疗后随访中的应用价值.医学影像学杂志,2007,17(7):674-676.
[10] 林映如,陈应瑞,李伟雄.FDG-PET判断鼻咽癌放疗后复发的临床价值.实用医学杂志,2005, 21(20):2269-2270.
[11] 田月丽,兰晓莉,吴志坚,等.18F-FDG PET/CT显像在鼻咽癌综合治疗后随访中的诊断及预后评估效能.中国医学影像技术, 2013,29(3):349-353.
[12] Chang JT, Chan SC, Yen TC, et al. Nasopharyngeal carcinoma staging by 18F-fluorodeoxyglucose positron emission tomography. Int J Radiat Oncol Biol Phys, 2005, 62(2):501-507.
[13] 李天然,田嘉禾,赵春雷,等.18F-FDG PET/CT评估鼻咽癌远处间隔转移及诊断效能.医学研究杂志,2008, 27(11):39-42.
[14] 罗耀武,马冬,唐安戊,等.鼻咽癌放疗后病灶残留或复发18F-FDG PET显像的诊断价值.广东医学,2005,26(9):1228-1230.
[15] Schwartz DL, Ford E, Rajendran J, et al. FDG PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys, 2005,61(1):129-136.
[16] Chua DT, Sham JS, Wei WI, et al. The predictive value of the 1997 American Joint Committee on Cancer stage classification in determining failure patterns in nasopharyngeal carcinoma. Cancer, 2001, 92(11):2845-2855.
[17] Zheng XK, Chen LH, Wang QS, et al. Influence of[18F] fluo-rodeoxyglucose positron emission tomography on salvage treatment decision making for locally persistent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys, 2006, 65(4):1020-1025.
[18] Krishna SM, James S, Balaram P. Expression of VEGF as prognosticator in primary nasopharyngeal cancer and its relation to EBV status. Virus Res, 2006, 115(1):85-90.
[19] Lee SW, Nam SY, Im KC, et al. Prediction of prognostic using standardized uptake value of 2-18F-fluoro-2-deoxy-d-gluecose positron emission tomography for nasopharyngeal carcinomas. Radiother Oncol, 2008, 87(2):211-216.
[20] Xie P, Yue JB, Fu Z, et al. Prognostic value of 18F-FDG PET/CT before and after radiotheraphy for locally advanced nasopharyngeal carcinoma. Ann Oncol, 2010, 21(5):1078-1082.
[21] Xie P, Yue JB, Zhao HX, et al. Prognostic value of 18F-FDG PET/CT metabolic index for nasopharyngeal carcinoma. J Cancer Res Clin Oncol, 2010,136(6):883-889.
[22] Larson SM, Erdi Y, Akhurst T, et al. Tumour treatment response based on visual and quantitative changes in globed tumour glycolysis using PET-FDG imaging.the visual response score and the change in total lesion glycolysis. Clin Positron Imging, 1999, 2(3):159-171.
[23] Chan WK, Mak HK, Huang DW, et al. Nasopharyngeal carcinoma:relationship between 18F-FDG PET-CT maximum standardized uptake value, metabolic tumor volume and total lesion glycolysis and TNM classification. Nucl Med Commun, 2010,31(3):206-210.
[24] Yong H, Baum R, Cremerius U, et al. Measurement of clinical and subclinical tumour response using 18F-fluorodeoxyglucose and positron emission tomography:review and 1999 EORTC recommendation. European Organization for Research and Treatment of Cancer (EORTC) PET Study Group. Eur J Cancer, 1999, 35(13):1773-1782.
[25] 王国慧,Lau E W F,Shakher R,等.18F-FDG PET/CT显像在鼻咽癌分期及疗效监测中的应用价值.癌症,2007, 26(6):638-642.

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备注/Memo

备注/Memo:
收稿日期:2012-12-06。
基金项目:国家高技术研究发展计划(863计划)项目(2008A-A022426)
通讯作者:兰晓莉,Email:hzslxl@163.com
更新日期/Last Update: 1900-01-01